Results 271 to 280 of about 1,829,235 (358)

Semisynthetic b-Lactam Antibiotics. V. Synthesis of a-Sulfobenzylpenicillin by Using Mixed Anhydride and Active Ester of a-Sulfophenylacetic Acid

, 1974
Shiro Morimoto, Hiroaki Nomura, Toshihiro Ishiguro, Takeshi Fugono, K Maeda   +4 more
openalex   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Baseline Procalcitonin Levels and Their Association with Antibiotic Exposure and Clinical Outcomes in Critically Ill Patients with Suspected Bacterial Infection: A Retrospective Cohort Study. [PDF]

Healthcare (Basel)
Suranadi IW, Wisnawa ADF, Parami P, Hartawan IGAGU, Sinardja CD, Djedoma AI.   +5 more
europepmc   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Antimicrobial Prescribing Practices for Surgical Prophylaxis in Caesarean Sections at Kawempe National Referral Hospital, Kampala, Uganda. [PDF]

Health Sci Rep
Nkalubo J, Goulart DB, Mitra A, Martin A, Amponsah RD, Murugappan M, Ademola EA, Nyiro B, Namatovu I, Lamorde M, Kajumbula H, Beaudoin A, Kline S.   +12 more
europepmc   +1 more source

Antibiotic resistance

International Journal of Medical Microbiology, 2013
openaire   +2 more sources

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Early trajectories of antibiotic exposure and colonization pressure and risk of ICU-acquired carbapenem-resistant Gram-negative bacteria: A prospective cohort study. [PDF]

Ann Intensive Care
Chen Z, Ye X, Wu J, Li Z, Wang S, Wang J, Tian Y, Li S, Zhou L, Ni J, Qu Y, Jin J, Zhang W.   +12 more
europepmc   +1 more source