Results 41 to 50 of about 634,748 (302)

Avoiding pitfalls in antibiotic therapy: the antibiotic stewardship approach

Magna Scientia UCEVA, 2022
The aim of this reflection is to determine the effectiveness and safety of ABS interventions. A strong correlation between antibiotic overuse and the growing worldwide resistance, but also with individual side effects is well established and should open
Markus H. Huppertz-Thyssen, Carolina Rodriguez Saavedra   +1 more
doaj   +1 more source

Empirical Antibiotic Therapy Assessment of Patients Diagnosed with Sepsis in Intermediate Care Ward of Internal Medicine Department of Dr. Soetomo General Hospital According to Gyssens Method [PDF]

, 2018
Rational empirical antimicrobial therapy is an important component of sepsis patient management. This study aimed to assess the rationality of empirical antimicrobial therapy in patients diagnosed with sepsis admitted in intermediate care ward of ...
Adiwinoto, R. P. (Ronald), Hadi, U. (Usman), Hardiono, H. (Hardiono), Hidajat, B. (Boerhan), Sustini, F. (Florentina), Widodo, A. D. (Agung)   +5 more
core  

Antibiotic Stewardship Implementation and Antibiotic Use at Hospitals With and Without On-site Infectious Disease Specialists. [PDF]

, 2020
BackgroundMany US hospitals lack infectious disease (ID) specialists, which may hinder antibiotic stewardship efforts. We sought to compare patient-level antibiotic exposure at Veterans Health Administration (VHA) hospitals with and without an on-site ID
Alexander, Bruce, Beck, Brice F, Goetz, Matthew B, Goto, Michihiko, Livorsi, Daniel J, Lund, Brian C, Nair, Rajeshwari, Ohl, Michael, Perencevich, Eli N, Vaughan-Sarrazin, Mary S   +9 more
core   +3 more sources

Outbreak of Aeromonas hydrophila wound infections association with mud football [PDF]

, 2004
On 16 February 2002, a total of 26 people presented to the emergency department of the local hospital in the rural town of Collie in southwest Western Australia with many infected scratches and pustules distributed over their bodies.
Amanda Whittle, Assanta MA, Bloch T, Brandi G, Burke V, Fulghum DD, Gary K. Dowse, Gold WL, Hassan Vally, Hazen TC, Houston CW, Kaper JB, Kelly KA, Scott Cameron, Semel JD, Tony Watson, Weber CA   +16 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Investigating the phenotypic alterations associated with hypermucoviscous hypervirulent Klebsiella pneumoniae during phage resistance development

BMC Microbiology
Phage therapy has been explored and used compassionately in the post-antibiotic era, though phage resistance might pose a serious challenge. The advent of hypervirulent and hypermucoviscous traits in Klebsiella pneumoniae limits therapeutic choices. This
Ramya Juliet, Ramesh Nachimuthu
doaj   +1 more source

Pharmacoeconomics of Antibiotic Therapy

Canadian Journal of Infectious Diseases, 1994
During the past few years new drugs with greatly improved efficacy have become available to physicians and their patients. The higher purchase price of these new drugs is quite important and is quoted as a significant cause of the escalating cost of ...
Jacques Le Lorier
doaj   +1 more source

Antibiotic stewardship for staff nurses: Five Key Ways you Influence Antibiotic Use [PDF]

, 2016
Over the past decade, antibiotic resistance has increased and spread dramatically throughout the world. According to the Centers for Disease Control and Prevention (CDC), antibiotic use is the single most important factor leading to antibiotic resistance.
Manning, PhD, CRNP, CIC, FAAN, Mary Lou
core   +1 more source

Infectious Diseases Associated With Renal Homotransplantation: I. Incidence, Types, and Predisposing Factors [PDF]

, 1964
Infectious diseases occurred in 26 of 30 renal homotransplantation patients and contributed to eight of the 12 deaths in this series. There were 52 infections, 17 occurring before and 35 after transplantation.
Marchioro, TL, Rifkind, D, Starzl, TE, Waddell, WR   +3 more
core   +1 more source