Results 81 to 90 of about 5,870,697 (401)

Clinical and economic consequences of failure of initial antibiotic therapy for patients with community-onset complicated intra-abdominal infections. [PDF]

PLoS ONE, 2015
Complicated intra-abdominal infection (cIAI) is infection that extends beyond the hollow viscus of origin into the peritoneal space, and is associated with either abscess formation or peritonitis. There are few studies that have assessed the actual costs
Yong Pil Chong, In-Gyu Bae, Sang-Rok Lee, Jin-Won Chung, Jae-Bum Jun, Eun Ju Choo, Soo-youn Moon, Mi Suk Lee, Min Hyok Jeon, Eun Hee Song, Eun Jung Lee, Seong Yeon Park, Yang Soo Kim   +12 more
doaj   +1 more source

Epidemiology and Economic Outcomes Associated with Timely versus Delayed Receipt of Appropriate Antibiotic Therapy among US Patients Hospitalized for Native Septic Arthritis: A Retrospective Cohort Study

Antibiotics, 2022
Timely administration of appropriate antibiotic therapy is associated with better patient outcomes and lower costs of care compared to delayed appropriate therapy, yet initial treatment is often empiric since causal pathogens are typically unknown upon ...
Joan-Miquel Balada-Llasat, Nicole Stamas, Tom Vincent, Tristan T. Timbrook, Cynthia Saiontz-Martinez, Rachael B. Hemmert, Ariel Berger   +6 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Experimental phage therapy of burn wound infection : difficult first steps [PDF]

, 2014
Antibiotic resistance has become a major public health problem and the antibiotics pipeline is running dry. Bacteriophages (phages) may offer an ‘innovative’ means of infection treatment, which can be combined or alternated with antibiotic therapy and ...
De Vos, Daniel, Jennes, Serge, Lavigne, Rob, Merabishvili, Maia, Pirnay, Jean Paul, Rose, Thomas, Vaneechoutte, Mario, Verbeken, Gilbert, Zizi, Martin   +8 more
core  

Dietary-based gut flora modulation against Clostridium difficile onset [PDF]

, 2007
Clostridium difficile infection is a frequent complication of antibiotic therapy in hospitalised patients, which today is attracting more attention than ever and has led to its classification as a 'superbug'.
Gibson, G.R., Gougoulias, C., Tuohy, K.M.   +2 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Empirical use of antibiotics and adjustment of empirical antibiotic therapies in a university hospital: a prospective observational study

BMC Infectious Diseases, 2007
Background Several strategies to optimise the use of antibiotics have been developed. Most of these interventions can be classified as educational or restrictive.
Battegay Manuel, Bingisser Roland, Widmer Andreas F, Sendi Pedram, Simcock Mathew, Mettler Julian, Fluckiger Ursula, Bassetti Stefano   +7 more
doaj   +1 more source

Immunoblot analysis of the seroreactivity to recombinant Borrelia burgdorferi sensu lato antigens, including VlsE, in the long-term course of treated patients with Erythema migrans [PDF]

, 2008
Objective: We evaluated whether immunoblotting is capable of substantiating the posttreatment clinical assessment of patients with erythema migrans ( EM), the hallmark of early Lyme borreliosis.
Aguero-Rosenfeld ME, Aguero-Rosenfeld ME, Aguero-Rosenfeld ME, Bacon RM, Bettina Wilske, Bono JL, Bruckbauer HR, Christina Ambros-Rudolph, Coleman JL, Dressler F, Engstrom SM, Feder, Fung BP, Glatz M, Goettner G, Grodzicki RL, Guo BP, Hansen K, Hauser U, Helmut Kerl, Hofmann H, Hulshof MM, Jauris-Heipke S, Kalish RA, Lahdenne P, Lebech AM, Ledue TB, Liang FT, Liang FT, Magnarelli LA, Magnarelli LA, Marangoni A, Martin Glatz, Massarotti EM, Mullegger RR, Peltomaa M, Philipp MT, Picken MM, Plorer A, Rasiah C, Robert R. Müllegger, Roessler D, Ruzic-Sabljic E, Ryffel K, Shadick NA, Sillanpaa H, Simpson WJ, Smith RP, Stanek G, Stanek G, Volker Fingerle, Volkman DJ, Wilske B, Wilske B, Wilske B, Wilske B, Wormser GP, Zhang JR   +57 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Current Aspects of Antibiotic Therapy of Community-Acquired Pneumonia in Children of Early and Preschool Age (Review)

Zdorovʹe Rebenka, 2016
In this article we analyzed current antibiotic resistance of S.pneumoniae. We showed local (region) data on sensitivity of pneumococcus to aminopenicillins, macrolides and cephalosporines traditionally used in schemes of empirical antibiotic therapy of ...
S.A. Mokiya-Serbina, T.V. Litviniva, A.A. Gordyeyeva   +2 more
doaj   +1 more source