Results 101 to 110 of about 951,869 (260)

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, Volume 90, Issue 12, December 10, 2025.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

The Capacity of Mycobacterium tuberculosis To Survive Iron Starvation Might Enable It To Persist in Iron-Deprived Microenvironments of Human Granulomas

mBio, 2017
This study was conducted to investigate the role of iron deprivation in the persistence of Mycobacterium tuberculosis. We present evidence of iron restriction in human necrotic granulomas and demonstrate that under iron starvation M.
Krishna Kurthkoti, Hamel Amin, Mohlopheni J. Marakalala, Saleena Ghanny, Selvakumar Subbian, Alexandra Sakatos, Jonathan Livny, Sarah M. Fortune, Michael Berney, G. Marcela Rodriguez   +9 more
doaj   +1 more source

δ-Hydroxy-γ-oxo-L-norvaline, a New Antitubercular Antibiotic. (3). Structural Analogs ; their Structure and Antitubercular Actitvity.

Chemical and Pharmaceutical Bulletin, 1960
Sixteen homologs of L-HON were synthesized and their in vitro activity against M. tuberculosis was tested. From such results, L-HON was classified as a member of the group which is relatively low in molecular weight and active only against M. tuberculosis.
openaire   +2 more sources

Natural carriers for application in tuberculosis treatment [PDF]

, 2012
Tuberculosis remains the leading cause of preventable deaths worldwide and unsuccessful therapy is mainly due to non-compliance with very prolonged treatments, often associated with severe side-effects.
Ahmad Z, Ahmad Z, Ahmad Z, Ahmad Z, Ahmad Z, Ahsan F, Ain Q, Al-Qadi S, Ana Grenha, Anwunobi A, Armstead A, Attama A, Azarmi S, Barrow W, Beneke C, Blasi P, Borges O, Braz L, Devi N, Doherty T, Dyala’A GG, Florence A, George M, Grabovac V, Grenha A, Grenha A, Hans M, Hugo Costa, Hunter RL, Hwang SM, Lehr C-M, Lewis C, Liu Z, Lu E, Malafaya P, Martins S, Misra A, Mizoe T, Mizrahy S, Mosser D, Murata Y, Pandey R, Pandey R, Pandey R, Pinto Reis C, Ranjita S, Russell D, Smola M, Sudhakar Y, Taylor P, Yadav AB, Zara GP   +51 more
core   +1 more source

Antibacterial and Antibiofilm Activity of 8‐Hydroxyquinoline Derivatives Against Mycobacterium and Staphylococcus Species

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
Synthesis of 8‐hydroxyquinoline derivatives (QD 1‐12) from different analogues of 8‐hydroxyquinoline (HQ 1‐4). The derivatives and parent compounds were evaluated for antibacterial and antibiofilm activity against Mycobacterium tuberculosis, Mycobacterium smegmatis, methicillin‐resistant Staphylococcus aureus and methicillin‐sensitive Staphylococcus ...
Namrita Lall, Anna‐Mari Kok, Carel B. Oosthuizen, Surjeet Verma, François Chassagne, Phuc H. Vo, Khanh‐Van Ho, Chung‐Ho Lin, Cassandra L. Quave, Danielle Twilley   +9 more
wiley   +1 more source

Papulo necrotic tuberculid :An imitator

Indian Journal of Dermatology, 2005
A 22 year old female presented with asymptomatic papules, pustules and crusted lesions appearing in crops over the extensor aspect of both upper and lower limbs, palms and soles and sun exposed part of the back.
Sirka C, Jena S, Padhi T, Mishra S, Mohanty P   +4 more
doaj  

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Synthesis of hexahydrofuro[3,2-c]quinoline, a martinelline type analogue and investigation of its biological activity [PDF]

, 2016
2015-2016 > Academic research: refereed > Publication in refereed journalVersion of ...
C.-H. Cheng, C.-H. Chui, J. C.-O. Tang, K.-H. Lam, P.-Y. Chung, W.-Y. Wong, Z.-X. Bian   +6 more
core   +1 more source

Antibiotics-related adverse drug reactions at a tertiary care hospital in North India

International Journal of Basic & Clinical Pharmacology, 2019
Background: Antibiotics are considered to be commonly used drugs in hospital setting due to higher prevalence of infectious diseases especially in India.
S. Rani, B. Sharma, Tarun, Sanjeev Kumar, R. Saini   +4 more
semanticscholar   +1 more source

Unusual Presentation of Subcutaneous Panniculitis‐Like T‐Cell Lymphoma

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Subcutaneous panniculitis‐like T‐cell lymphoma (SPTCL) is a rare variant of primary cutaneous T‐cell lymphoma primarily affecting subcutaneous adipose tissue and mimicking lobular panniculitis. It often presents with erythematous subcutaneous nodules or plaques, and diagnosis can be challenging due to its diverse clinical manifestations.
Mona Alkallabi, Hend Alotaibi, Khalid Nabil Nagshabandi, Reem Bin Idris, Amal H. Abualola, Naif Ahmed Alshehri, Ahmed Alhumidi   +6 more
wiley   +1 more source