Antibiotics, 2022 Rifampicin is a critical first-line antibiotic for treating mycobacterial infections such as tuberculosis, one of the most serious infectious diseases worldwide.
T. T. Do +5 more
semanticscholar +1 more source
Semisynthetic modifications of antitubercular lanostane triterpenoids from Ganoderma
Journal of antibiotics (Tokyo. 1968), 2021 Antitubercular lanostane triterpenoids isolated from mycelial cultures of the basidiomycete Ganoderma australe were structurally modified by semisynthesis. One of the synthetic compounds, named GA003 (9), showed more potent activity against Mycobacterium
Panida Chinthanom +5 more
semanticscholar +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
The prodrug activator EtaA from Mycobacterium tuberculosis is a Baeyer-Villiger monooxygenase [PDF]
, 2004 EtaA is a newly identified FAD-containing monooxygenase that is responsible for activation of several thioamide prodrugs in Mycobacterium tuberculosis.
Fortin, R +3 more
core +5 more sources
Molecules, 2022 Natural and synthetic β-lactam derivatives constitute an interesting class of compounds due to their diverse biological activity. Mostly used as antibiotics, they were also found to have antitubercular, anticancer and antidiabetic activities, among ...
Faïza Diaba +2 more
doaj +1 more source
Phenothiazines as a solution for multidrug resistant tuberculosis: From the origin to present [PDF]
, 2015 Historically, multiplicity of actions in synthetic compounds is a rule rather than exception. The science of non-antibiotics evolved in this background.
Debalina Sinha Roy +6 more
core +7 more sources
Synthesis of 2-oxo-azetidine derivatives of 2-amino thiazole and their biological activity [PDF]
, 2012 A new series of N-[2-(2-aminothiazolyl)ethyl]-4-(substitutedphenyl)- 3-chloro-2-oxo-1-iminoazetidine, compounds 4(a-m) have been synthesized from 2-aminothiazole as a starting material.
Samadhiya Pushkal +3 more
core +1 more source
Tubercular round pneumonia simulating a mass lesion in an adult
The Egyptian Journal of Internal Medicine, 2018 Round pneumonia, a benign cause of spherical lesions seen on chest imaging, can many a times be difficult to distinguish from bronchogenic carcinomas. Although relatively less common in adults, this entity is seen in most pulmonary medicine and radiology
Ved Prakash +5 more
doaj +1 more source
Synthesis and Biological Evaluation of a Novel C8-Pyrrolobenzodiazepine (PBD) Adenosine Conjugate. A Study on the Role of the PBD Ring in the Biological Activity of PBD-Conjugates [PDF]
, 2020 Here we sought to evaluate the contribution of the PBD unit to the biological activity of PBD-conjugates and, to this end, an adenosine nucleoside was attached to the PBD A-ring C8 position.
Bhakta, Sanjib +4 more
core +4 more sources
Drug delivery systems for potential treatment of intracellular bacterial infections. [PDF]
, 2010 Despite the advent of a considerable number of new antibiotics, treatment of intracellular pathogens still represents a major pharmaceutical challenge.
Ariza, J. (J.) +3 more
core +1 more source