Results 71 to 80 of about 2,694,182 (391)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

‘There is no choice apart from antibiotics…’: qualitative analysis of views on urinary infections in pregnancy and antimicrobial resistance [PDF]

, 2020
Background: Antimicrobial resistance (AMR) is a health risk as it can lead to life-threatening infections. There has been a rise in resistant urinary tract infections (UTIs) which is the most common infection in pregnancy.
Bandura A, Bandura A, Bandura A, Elzayat MA, Ghouri F, Luszczynska A, Ogden J, Ogden J, World Health Organisation   +8 more
core   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Antimicrobial Properties of Eremoxylarin A Produced by Ascomycete of Sordariomycetes in Submerged Culture

Антибиотики и Химиотерапия, 2020
The fungal strain INA 01108 producing antibiotic substances with broad spectrum of antibacterial activity was isolated from the natural environment.
O. V. Efremenkova, B. F. Vasiljeva, V. A. Zenkova, A. M. Korolev, Y. N. Lusikov, T. A. Efimenko, I. A. Malanicheva, E. P. Mirchink, E. B. Isakova, E. N. Bilanenko, O. V. Kamzolkina   +10 more
doaj  

Evaluation of the Immunochromatographic NG-Test Carba 5, RESIST-5 O.O.K.N.V., and IMP K-SeT for Rapid Detection of KPC-, NDM-, IMP-, VIM-type, and OXA-48-like Carbapenemase Among Enterobacterales

Frontiers in Microbiology, 2021
BackgroundEnterobacterales are the most common pathogens for nosocomial infections. The emergence and spread of KPC, NDM, and OXA-48-like carbapenemase-producing Enterobacterales with their extensively drug-resistant characteristics have posed great ...
Renru Han, Renru Han, Yan Guo, Yan Guo, Mingjia Peng, Mingjia Peng, Qingyu Shi, Qingyu Shi, Shi Wu, Shi Wu, Yang Yang, Yang Yang, Yonggui Zheng, Yonggui Zheng, Dandan Yin, Dandan Yin, Fupin Hu, Fupin Hu   +17 more
doaj   +1 more source

Antibiotics in the Soil Environment—Degradation and Their Impact on Microbial Activity and Diversity

Frontiers in Microbiology, 2019
Antibiotics play a key role in the management of infectious diseases in humans, animals, livestock, and aquacultures all over the world. The release of increasing amount of antibiotics into waters and soils creates a potential threat to all ...
M. Cycoń, A. Mrozik, Z. Piotrowska-Seget   +2 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

COMPOUNDS BASED ON TRIS(1-ALKYLINDOL-3-YL)METHAN FOR OVERCOMING DRUG RESISTANCE IN PATHOGENS

Антибиотики и Химиотерапия, 2020
Trls(1-alkylindol-3-yl)methylium salts that are trls(1-alkylindol-3-yl)methan derivatives with high antibacterial and antifungal activity were obtained through chemical synthesis.
A. S. Trenin, S. N. Lavrenov, E. P. Mirchink, E. B. Isakova, O. P. Bychkova, A. Y. Simonov, S. A. Lakatosh, E. A. Tsvigun   +7 more
doaj  

Development of a risk prediction model for bloodstream infection in patients with fever of unknown origin

Journal of Translational Medicine, 2022
Background Bloodstream infection (BSI) is a significant cause of mortality among patients with fever of unknown origin (FUO). Inappropriate empiric antimicrobial therapy increases difficulty in BSI diagnosis and treatment.
Teng Xu, Shi Wu, Jingwen Li, Li Wang, Haihui Huang   +4 more
doaj   +1 more source

Optimization of the Nutrient Medium for Flammulina velutipes Submerged Biomass Production and Micromorphology of Its Mycelium

Fermentation, 2021
Based on the assessment of the trophic needs of basidiomycete Flammulina velutipes and the optimization of the composition of the nutrient medium using design of experimental approach, the yield of the submerged biomass of the fungus was increased to 41 ...
Larissa Krasnopolskaya, Maria Shuktueva, Aleksandr Golyshkin, Nailya Almyasheva, Maria Yarina   +4 more
doaj   +1 more source