Specific binding of the pathogenic prion isoform: development and characterization of a humanized single-chain variable antibody fragment. [PDF]
PLoS ONE, 2011 Murine monoclonal antibody V5B2 which specifically recognizes the pathogenic form of the prion protein represents a potentially valuable tool in diagnostics or therapy of prion diseases. As murine antibodies elicit immune response in human, only modified
Nives Skrlj +4 more
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Novel humanized monoclonal antibodies against ROR1 for cancer therapy [PDF]
Molecular CancerBackground Overexpression of receptor tyrosine kinase-like orphan receptor 1 (ROR1) contributes to cancer cell proliferation, survival and migration, playing crucial roles in tumor development. ROR1 has been proposed as a potential therapeutic target for
Rong Wei +5 more
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A Review of Therapeutic Antibodies in Breast Cancer
Journal of Pharmacy & Pharmaceutical Sciences, 2021 Since the first production of monoclonal antibodies about 35 years ago, researchers have found them useful in the treatment and diagnosis of various diseases such as cancer.
Maryam Eini +4 more
doaj +1 more source
Unique allergen-specific human IgE monoclonal antibodies derived from patients with allergic disease
Frontiers in Allergy, 2023 IntroductionAllergic reactions are mediated by human IgE antibodies that bind to and cross-link allergen molecules. The sites on allergens that are recognized by IgE antibodies have been difficult to investigate because of the paucity of IgE antibodies ...
Bryan R. E. Smith +11 more
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Human monoclonal antibodies and monoclonal antibody multispecificity [PDF]
British Journal of Cancer, 1987 The majority of human anti-tumour monoclonal antibodies (Mabs) isolated to date have been disappointing. Firstly, they react or cross react with intracellular cytoskeletal proteins or nuclear antigens and therefore are of limited value as blood borne agents.
AM Campbell, P Whitford, RE Leake
openaire +2 more sources
Novel Clostridium difficile Anti-Toxin (TcdA and TcdB) Humanized Monoclonal Antibodies Demonstrate In Vitro Neutralization across a Broad Spectrum of Clinical Strains and In Vivo Potency in a Hamster Spore Challenge Model. [PDF]
PLoS ONE, 2016 Clostridium difficile (C. difficile) infection (CDI) is the main cause of nosocomial antibiotic-associated colitis and increased incidence of community-associated diarrhea in industrialized countries.
Hongyu Qiu +17 more
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Antibody binding reports spatial heterogeneities in cell membrane organization [PDF]
, 2022 The spatial organization of cell membrane glycoproteins and glycolipids is critical for mediating the binding of ligands, receptors, and macromolecules on the plasma membrane. However, we currently do not have the methods to quantify the spatial heterogeneities of macromolecular crowding on live cell surfaces.
arxiv +1 more source
A humanized anti-VEGF rabbit monoclonal antibody inhibits angiogenesis and blocks tumor growth in xenograft models. [PDF]
PLoS ONE, 2010 Rabbit antibodies have been widely used in research and diagnostics due to their high antigen specificity and affinity. Though these properties are also highly desirable for therapeutic applications, rabbit antibodies have remained untapped for human ...
Yanlan Yu +13 more
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New and Old Anti-CD20 Monoclonal Antibodies for Nephrotic Syndrome. Where We Are?
Frontiers in Immunology, 2022 Nephrotic proteinuria is the hallmark of several glomerulonephritis determined by different pathogenetic mechanisms, including autoimmune, degenerative and inflammatory.
Biswanath Basu +5 more
doaj +1 more source
In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development [PDF]
, 2017 Acknowledgments: The authors would like to acknowledge the funding support for this work from Scottish Enterprise [VNAR_001(2012)] and the Biotechnology and Biological Sciences Research Council (BB/K010905/1).Peer reviewedPublisher ...
Andrew J. Porter +11 more
core +6 more sources