Results 1 to 10 of about 56,276 (247)

A Review of Therapeutic Antibodies in Breast Cancer

Journal of Pharmacy & Pharmaceutical Sciences, 2021
Since the first production of monoclonal antibodies about 35 years ago, researchers have found them useful in the treatment and diagnosis of various diseases such as cancer.
Maryam Eini, Nahid Zainodini, Hamed Montazeri, Parastoo Mirzabeigi, Parastoo Tarighi   +4 more
doaj   +1 more source

Unique allergen-specific human IgE monoclonal antibodies derived from patients with allergic disease

Frontiers in Allergy, 2023
IntroductionAllergic reactions are mediated by human IgE antibodies that bind to and cross-link allergen molecules. The sites on allergens that are recognized by IgE antibodies have been difficult to investigate because of the paucity of IgE antibodies ...
Bryan R. E. Smith, Kristina Reid Black, Max Bermingham, Sayeh Agah, Jill Glesner, Serge A. Versteeg, Ronald van Ree, Glorismer Pena-Amelunxen, Lorenz Aglas, Scott A. Smith, Anna Pomés, Martin D. Chapman   +11 more
doaj   +1 more source

Human monoclonal antibodies and monoclonal antibody multispecificity [PDF]

British Journal of Cancer, 1987
The majority of human anti-tumour monoclonal antibodies (Mabs) isolated to date have been disappointing. Firstly, they react or cross react with intracellular cytoskeletal proteins or nuclear antigens and therefore are of limited value as blood borne agents.
AM Campbell, P Whitford, RE Leake
openaire   +2 more sources

Novel Clostridium difficile Anti-Toxin (TcdA and TcdB) Humanized Monoclonal Antibodies Demonstrate In Vitro Neutralization across a Broad Spectrum of Clinical Strains and In Vivo Potency in a Hamster Spore Challenge Model. [PDF]

PLoS ONE, 2016
Clostridium difficile (C. difficile) infection (CDI) is the main cause of nosocomial antibiotic-associated colitis and increased incidence of community-associated diarrhea in industrialized countries.
Hongyu Qiu, Robyn Cassan, Darrell Johnstone, Xiaobing Han, Antony George Joyee, Monica McQuoid, Andrea Masi, John Merluza, Bryce Hrehorak, Ross Reid, Kieron Kennedy, Bonnie Tighe, Carla Rak, Melanie Leonhardt, Brian Dupas, Laura Saward, Jody D Berry, Cory L Nykiforuk   +17 more
doaj   +1 more source

A humanized anti-VEGF rabbit monoclonal antibody inhibits angiogenesis and blocks tumor growth in xenograft models. [PDF]

PLoS ONE, 2010
Rabbit antibodies have been widely used in research and diagnostics due to their high antigen specificity and affinity. Though these properties are also highly desirable for therapeutic applications, rabbit antibodies have remained untapped for human ...
Yanlan Yu, Pierre Lee, Yaohuang Ke, Yongke Zhang, Qiu Yu, Jonathan Lee, Mingzhen Li, Jialiang Song, Jungang Chen, Jihong Dai, Fernando Jose Rebelo Do Couto, Zhiqiang An, Weimin Zhu, Guo-Liang Yu   +13 more
doaj   +1 more source

New and Old Anti-CD20 Monoclonal Antibodies for Nephrotic Syndrome. Where We Are?

Frontiers in Immunology, 2022
Nephrotic proteinuria is the hallmark of several glomerulonephritis determined by different pathogenetic mechanisms, including autoimmune, degenerative and inflammatory.
Biswanath Basu, Andrea Angeletti, Andrea Angeletti, Bilkish Islam, Gian Marco Ghiggeri, Gian Marco Ghiggeri   +5 more
doaj   +1 more source

Anti-IL-6 therapies in central nervous system inflammatory demyelinating diseases

Frontiers in Immunology, 2022
Current treatments for central nervous system (CNS) inflammatory demyelinating diseases (IDDs) include corticosteroids, plasma exchange, intravenous immunoglobulin, and immunosuppressant drugs.
Li Jiao, Shougang Guo, Shougang Guo
doaj   +1 more source

Neutralizing Anti-Rituximab Antibodies and Relapse in Membranous Nephropathy Treated With Rituximab

Frontiers in Immunology, 2020
Membranous Nephropathy (MN) is an autoimmune disease associated with antibodies against podocyte proteins: M-type phospholipase A2 receptor (PLA2R1) or thrombospondin type-1 domain-containing 7A (THSD7A) in 70 and 3% of patients, respectively.
Sonia Boyer-Suavet, Sonia Boyer-Suavet, Marine Andreani, Maël Lateb, Benjamin Savenkoff, Vesna Brglez, Sylvia Benzaken, Ghislaine Bernard, Patrick H. Nachman, Vincent Esnault, Vincent Esnault, Barbara Seitz-Polski, Barbara Seitz-Polski, Barbara Seitz-Polski   +13 more
doaj   +1 more source

Specific binding of the pathogenic prion isoform: development and characterization of a humanized single-chain variable antibody fragment.

PLoS ONE, 2011
Murine monoclonal antibody V5B2 which specifically recognizes the pathogenic form of the prion protein represents a potentially valuable tool in diagnostics or therapy of prion diseases. As murine antibodies elicit immune response in human, only modified
Nives Skrlj, Tanja Vranac, Mara Popović, Vladka Curin Šerbec, Marko Dolinar   +4 more
doaj   +1 more source

Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections

Nature Communications, 2021
Here, the authors identify and characterize two mouse-derived monoclonal antibodies against SARS-CoV-2 spike protein that target different epitopes in RBD and block the interaction S/ACE2 and show that a formulated humanized version cocktail exhibits ...
Chao Zhang, Yifan Wang, Yuanfei Zhu, Caixuan Liu, Chenjian Gu, Shiqi Xu, Yalei Wang, Yu Zhou, Yanxing Wang, Wenyu Han, Xiaoyu Hong, Yong Yang, Xueyang Zhang, Tingfeng Wang, Cong Xu, Qin Hong, Shutian Wang, Qiaoyu Zhao, Weihua Qiao, Jinkai Zang, Liangliang Kong, Fangfang Wang, Haikun Wang, Di Qu, Dimitri Lavillette, Hong Tang, Qiang Deng, Youhua Xie, Yao Cong, Zhong Huang   +29 more
doaj   +1 more source