Results 151 to 160 of about 56,276 (247)

Preclinical Characterization of Efficacy and Pharmacodynamic Properties of Finotonlimab, a Humanized Anti-PD-1 Monoclonal Antibody. [PDF]

open access: yesPharmaceuticals (Basel)
Yao Y   +15 more
europepmc   +1 more source

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

open access: yesPeriodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva   +2 more
wiley   +1 more source

Neutralization of Marinobufagenin Demonstrates Efficacy In Vitro and In Vivo in Models of Pre-Eclampsia. [PDF]

open access: yesBiomedicines
Pantho AF   +8 more
europepmc   +1 more source

Updated insights into the molecular pathogenesis of canine atopic dermatitis

open access: yesVeterinary Dermatology, EarlyView.
Abstract Atopic dermatitis (AD) is a common and chronic inflammatory skin disease with frequent relapses. The genomics revolution has greatly contributed and revolutionised our knowledge of human AD; understanding the molecular skin fingerprint of AD and associated pathogenic immune pathways has led to preclinical assessments of several novel ...
Frane Banovic
wiley   +1 more source

Transcriptomic profiling of dorsal root ganglia in atopic and healthy dogs: A comparative RNA sequencing study with implications in cutaneous itch research

open access: yesVeterinary Dermatology, EarlyView.
Background – Itch is a common symptom in skin disorders. While the neural pathways of itch transmission from the skin to the brain are well‐understood in rodents, the same pathways in dogs remain unclear. The knowledge gap hinders the development of effective treatments for canine itch‐related disorders.
Chie Tamamoto‐Mochizuki   +1 more
wiley   +1 more source

Subtle Alterations in Hippocampal Neuronal Activity Coincide With Early Sex‐Specific Differences in Amyloidosis and Microglia in a Pre‐Symptomatic Mouse Model of Alzheimer‐Like Pathology

open access: yesGlia, Volume 73, Issue 8, Page 1727-1745, August 2025.
Main Points In a pre‐symptomatic mouse model of Alzheimer disease, despite higher amyloid‐β load females display less plaques than males. More efficient synaptic transmission as well as less microgliosis point to better early coping with pathogenesis in females.
Thomas Chaigneau   +7 more
wiley   +1 more source

Synbiotics of Lactobacillus suilingensis and inulin alleviates cognitive impairment via regulating gut microbiota indole‐3‐lactic acid metabolism in female AD mice

open access: yesAlzheimer's &Dementia, Volume 21, Issue 7, July 2025.
Abstract INTRODUCTION Recent studies have found that gut microbial tryptophan metabolism is altered in Alzheimer's disease (AD) patients. However, the functional consequences of these changes and their therapeutic potential remain unclear. METHODS The metagenomic data of 49 preclinical AD patients and 115 healthy controls were analyzed.
Cong Yang   +15 more
wiley   +1 more source

Temporal Galactose‐Manganese Feeding in Fed‐Batch and Perfusion Bioreactors Modulates UDP‐Galactose Pools for Enhanced mAb Glycosylation Homogeneity

open access: yesBiotechnology and Bioengineering, Volume 122, Issue 7, Page 1710-1723, July 2025.
This study investigates the temporal effects of galactose and manganese on the N‐glycosylation of Trastuzumab (mAb) antibody during fed‐batch and perfusion bioprocessing modes to reveal the influence of feeding schedules on mAb N‐glycosylation patterns. These findings will aid in building process control schemes for mAb bioprocessing.
Aron Gyorgypal   +4 more
wiley   +1 more source

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