Results 151 to 160 of about 89,305 (304)

Targeting cancer expressed EGFR with a humanized monoclonal antibody. [PDF]

Sci Rep
Costa TGF, Sarnovsky R, Zhan J, Maslanka CA, Obiorah I, Xia D, FitzGerald D, Antignani A.   +7 more
europepmc   +1 more source

Dendrimeric Antigens for Passive Mast Cell Activation in the Evaluation of Amoxicillin Allergy

Allergy, EarlyView.
DeAns with defined nanoscale structure reveal that conjugate size and determinant density govern IgE‐mediated effector‐cell activation in AX allergy. All DeAn generations bind to sIgE in inhibition immunoassay, but only larger DeAns trigger FcεRI‐dependent responses in mouse MC, huRBL‐2H3, and LUVA cells.
Amene Tesfaye Ayane, Maria Salas, Sara Benede, Maria J. Rodriguez‐Sanchez, Maria J. Rodriguez‐Sojo, Isabel M. Jiménez‐Sánchez, Gador Bogas, Ezequiel Perez‐Inestrosa, Cristobalina Mayorga, Juan L. Paris, Alba Rodríguez‐Nogales, María J. Torres, María I. Montañez   +12 more
wiley   +1 more source

A humanized NOG-EXL mouse model for producing severe fever with thrombocytopenia syndrome virus-reactive human antibodies. [PDF]

Animal Model Exp Med
Lee DH, Bae J, Kim S, Song CY, Shin JH, Kim EH, Jang CH, Yun YS, Lee DS, Chu H, Choi JH, Kim CW.   +11 more
europepmc   +1 more source

Transgenesis and humanization of murine antibodies.

, 2009
International audienceThe properties of monoclonal antibodies explain why they are such a successful class of therapeutic molecules. However, pionneered initial antibodies were of murine origin and triggered an immune response which limited the ...
Cogné, Michel, Duchez, Sophie, Pascal, Virginie   +2 more
core   +1 more source

A Case for Anti‐IgE Vaccination

Allergy, EarlyView.
ABSTRACT Immunoglobulin E (IgE) plays a central role in allergic diseases by binding to the high‐affinity receptor FcεRI on mast cells and basophils, where allergen‐induced crosslinking triggers potent inflammatory responses. Various mechanisms by which IgE responses are generated and functionally regulated remain elusive despite many years of research.
Paul Engeroff, Zahra Gharailoo, Monique Vogel, Martin F. Bachmann   +3 more
wiley   +1 more source

Humanized anti-CD33 CAR-T cells and antibody-drug conjugates for targeted therapy in acute myeloid leukemia. [PDF]

Front Med (Lausanne)
Chen L, Duan H, Huang C, Xu Y, Wang Z, Huang H.   +5 more
europepmc   +1 more source

Tau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathy

Brain Pathology, EarlyView.
The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown, Jeanne K. Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Carare, Justin D. Boyd   +7 more
wiley   +1 more source

Wnt Signaling Downregulation Mediates T Cell Apoptosis Following OKT3-Induced T Cell Activation in Preclinical Models. [PDF]

FASEB J
Choi M, Park D, Lee DH, Choi CH, Jo M, Jeong SY, Lim SY, Park D, Moon KS.   +8 more
europepmc   +1 more source

Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease

Brain Pathology, EarlyView.
Neuritic plaques increase in the intermediate stage of Alzheimer's neuropathological change. The intermediate stage of Alzheimer's disease was investigated by transcriptomics and immunohistochemistry. This revealed that inflammasome sensors NLRP1, NLRP3, and AIM2 oligomerize with ASC speck to form the inflammasome complex and initiate the downstream ...
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

Antibodies to watch in 2026. [PDF]

MAbs
Crescioli S, Kaplon H, Chenoweth A, Hsu YS, Pinto K, Kapoor V, Reichert JM.   +6 more
europepmc   +1 more source