Results 31 to 40 of about 60,579 (143)

Human Monoclonal Antibodies Neutralizing Human Cytomegalovirus

Journal of General Virology, 1987
Hybridomas producing human monoclonal antibodies (MAbs) against human cytomegalovirus (CMV) were generated by fusion of human spleen cells and mouse myeloma cells. Two of the six MAbs obtained neutralized viral infectivity even at concentrations lower than 1 microgram/ml. One MAb required complement for neutralization but the other did not.
Y, Masuho, Y, Matsumoto, T, Sugano, S, Fujinaga, Y, Minamishima   +4 more
openaire   +2 more sources

A Novel Tau Antibody Detecting the First Amino-Terminal Insert Reveals Conformational Differences Among Tau Isoforms

Frontiers in Molecular Biosciences, 2020
As human Tau undergoes pathologically relevant post-translational modifications when expressed in yeast, the use of humanized yeast models for the generation of novel Tau monoclonal antibodies has previously been proven to be successful.
Joke Verelst, Nick Geukens, Sabiha Eddarkaoui, Dorien Vliegen, Elien De Smidt, Joëlle Rosseels, Vanessa Franssens, Sofie Molenberghs, Cindy Francois, Erik Stoops, Maria Bjerke, Maria Bjerke, Sebastiaan Engelborghs, Sebastiaan Engelborghs, Mohamed Laghmouchi, Sofie Carmans, Luc Buée, Eugeen Vanmechelen, Joris Winderickx, Debby Thomas   +19 more
doaj   +1 more source

γδ T-cell killing of primary follicular lymphoma cells is dramatically potentiated by GA101, a type II glycoengineered anti-CD20 monoclonal antibody

Haematologica, 2011
Background Anti-CD20 monoclonal antibodies are major therapeutic agents for patients with follicular lymphoma and work through complement-mediated cytotoxicity and antibody-dependent cellular cytotoxicity.
Mounia Sabrina Braza, Bernard Klein, Geneviève Fiol, Jean-François Rossi   +3 more
doaj   +1 more source

Comparative efficacy and safety of ocrelizumab in relapsing-remitting and primary progressive multiple sclerosis: A systematic review and meta-analysis

BMC Neurology
Objective This meta-analysis synthesizes evidence from all available randomized trials and observational cohort studies evaluating the efficacy and safety of ocrelizumab compared to placebo or active comparator therapies.
Adil Nawaz, Arsalan Bakhtiyar, Muhammad Ibrahim Khan, Erum Siddiqui, Elsa Khan, Muhammad Abbas, Muhammad Saad, Muhammad Qasim, Muhammad Taha   +8 more
doaj   +1 more source

Primary malignant melanoma of the uterine cervix treated with pembrolizumab after radical surgery: a case report and literature review [PDF]

Obstetrics & Gynecology Science, 2018
Malignant melanoma of the genital tract is a rare disease that is usually diagnosed by chance. When a definite diagnosis is delayed, the prognosis is very poor without standardized treatment. Herein, we describe a 40-year-old patient who presented with a
Myeong Seon Kim, Chel-Hun Choi, Tae-Joong Kim, Jeong-Won Lee, Jeeyun Lee, Duk-Soo Bae, Byoung-Gie Kim   +6 more
doaj   +1 more source

A rare adverse effect in inebilizumab therapy for neuromyelitis optica spectrum disorder: a case report

Therapeutic Advances in Neurological Disorders
Inebilizumab is one of the monoclonal antibodies approved as maintenance therapy for aquaporin-4 immunoglobulin G-seropositive neuromyelitis optica spectrum disorder (NMOSD).
Xuefen Chen, Ziyan Shi, Rui Wang, Hongyu Zhou   +3 more
doaj   +1 more source

Monoclonal Antibodies against Human Fibroblast Interferon [PDF]

Nature, 1981
A stable hybridoma clone derived by infusion of mouse myeloma cells (cell line Fo) and spleen cells of immunized mice has been isolated which secretes monoclonal antibodies against human fibroblast interferon (interferon-beta). The antibody inhibits the antiviral activity of human fibroblast interferon in an antiviral assay using human FS4 fibroblast ...
H K, Hochkeppel, U, Menge, J, Collins
openaire   +3 more sources

Recent Advances in the Development of Vaccines for Diabetes, Hypertension, and Atherosclerosis

Journal of Diabetes Research, 2018
Vaccines are commonly used in the prevention of infectious diseases. The basic principle of vaccination is to use specific antigens, endogenous or exogenous to stimulate immunity against the specific antigens or cells producing them. Autoantigen or oligo
Kongye Lu, Benli Su, Xiuxiang Meng
doaj   +1 more source

Dupilumab for recalcitrant prurigo nodularis: Case report

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2022
Dupilumab is a recombinant fully human monoclonal antibody modulating the signaling of the interleukin (IL)—4 and IL-13 pathways and has been approved for the treatment of moderate/severe atopic dermatitis.
Joel Reis, Inês Raposo, Manuela Selores
doaj  

ANTISENSE OLIGONUCLEOTIDES AND THERAPEUTICAL MONOCLONAL ANTIBODIES AS A BASEMENT FOR NOVEL BIOLOGICAL LIPIDLOWERING DRUGS

Российский кардиологический журнал, 2018
Development of innovational biotechnological medications based on humanized or completely human monoclonal antibodies or antisense oligonucleotides has opened a novel epoque in lipid disorders treatment. High efficacy of such biological drugs influencing
O. I. Afanasieva, M. V. Ezhov, S. N. Pokrovsky   +2 more
doaj   +1 more source