Results 81 to 90 of about 89,305 (304)
Primary malignant melanoma of the uterine cervix treated with pembrolizumab after radical surgery: a case report and literature review [PDF]
Obstetrics & Gynecology Science, 2018 Malignant melanoma of the genital tract is a rare disease that is usually diagnosed by chance. When a definite diagnosis is delayed, the prognosis is very poor without standardized treatment. Herein, we describe a 40-year-old patient who presented with a
Myeong Seon Kim +6 more
doaj +1 more source
Nanobodies as tools to understand, diagnose, and treat African trypanosomiasis [PDF]
, 2017 African trypanosomes are strictly extracellular protozoan parasites that cause diseases in humans and livestock and significantly affect the economic development of sub-Saharan Africa.
Caljon, Guy +5 more
core +1 more source
Monoclonal Antibodies against Human Fibroblast Interferon [PDF]
Nature, 1981 A stable hybridoma clone derived by infusion of mouse myeloma cells (cell line Fo) and spleen cells of immunized mice has been isolated which secretes monoclonal antibodies against human fibroblast interferon (interferon-beta). The antibody inhibits the antiviral activity of human fibroblast interferon in an antiviral assay using human FS4 fibroblast ...
H K, Hochkeppel, U, Menge, J, Collins
openaire +3 more sources
Advanced Science, EarlyView.This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård +19 more
wiley +1 more source
Dupilumab for recalcitrant prurigo nodularis: Case report
Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2022 Dupilumab is a recombinant fully human monoclonal antibody modulating the signaling of the interleukin (IL)—4 and IL-13 pathways and has been approved for the treatment of moderate/severe atopic dermatitis.
Joel Reis, Inês Raposo, Manuela Selores
doaj
Advanced Science, EarlyView.This study demonstrates significantly reduced Lkb1 expression in CD11c+ cells in chronic pancreatitis (CP) patients and animal models. Lkb1 deletion enhances CD11c+CD206+ macrophage infiltration and reprograms pancreatic stellate cells (PSCs) via OSM signaling.
Wenqing Zhang +10 more
wiley +1 more source
Recent Advances in the Development of Vaccines for Diabetes, Hypertension, and Atherosclerosis
Journal of Diabetes Research, 2018 Vaccines are commonly used in the prevention of infectious diseases. The basic principle of vaccination is to use specific antigens, endogenous or exogenous to stimulate immunity against the specific antigens or cells producing them. Autoantigen or oligo
Kongye Lu, Benli Su, Xiuxiang Meng
doaj +1 more source
A monoclonal antibody-based immunoassay to measure the antibody response against the repeat region of the circumsporozoite protein of Plasmodium falciparum [PDF]
, 2016 Background: The malaria vaccine candidate RTS, S/AS01 (GSK Vaccines) induces high IgG concentration against the circumsporozoite protein (CSP) of Plasmodium falciparum.
Clement, Frédéric +7 more
core +4 more sources
The characteristics of collagen‐induced rheumatoid arthritis in macaques and the changes of heart
Animal Models and Experimental Medicine, EarlyView.The disease progression in CIA macaques was categorized into three stages: IIR (days 14–34): The indicators related to rheumatoid arthritis and the levels of immunoglobulin were all elevated. There was a small amount of joint effusion, edema and mild synovial hyperplasia. No joint swelling was observed by naked eye.
Lei Zhang +8 more
wiley +1 more source
Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice. [PDF]
, 2019 BackgroundAlzheimer disease (AD) is characterized by the accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau, which together lead to neurodegeneration and cognitive decline.
Agadjanyan, Michael G +14 more
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