Inducible immortalized Dendritic Cells enable antigen-specific antibody production in a murine in vitro Immunization model. [PDF]
PLoS ONETransferring the complexity of the in vivo immune response into a controlled in vitro system represents a promising strategy for the rapid generation of antigen-specific antibodies while significantly reducing the reliance on animal experimentation, thus
Juliane Egert +3 more
doaj +2 more sources
Monoclonal antibody against canine distemper virus H protein potently neutralizes the giant panda-derived strain [PDF]
AMB ExpressCanine distemper virus (CDV) is a multi-host pathogen with high morbidity and mortality, posing a severe threat to endangered carnivores, including giant pandas.
Yunli Li +10 more
doaj +2 more sources
Development and Application of Mouse-Derived CD2v Monoclonal Antibodies Against African Swine Fever Virus from Single B Cells [PDF]
VirusesAfrican swine fever (ASF) is a highly pathogenic and hemorrhagic swine infectious disease caused by the African swine fever virus (ASFV). It encodes over 150 proteins, among which the CD2v protein plays multiple roles throughout the infection process ...
Litao Yu +9 more
doaj +2 more sources
T-cell responses against CD19-targeted CAR T cells varnimcabtagene autoleucel (ARI-0001): implications for immune response and therapy outcomes [PDF]
Journal for ImmunoTherapy of CancerPatients with B-cell malignancies receiving CD19-targeted chimeric antigen receptor (CAR) T-cell therapy may experience treatment failure due to various mechanisms.
Manel Juan +12 more
doaj +2 more sources
Establishment and Functional Characterization of Murine Monoclonal Antibodies Recognizing Neuritin
Antibodies, 2023 Neuritin represents a neurotrophic factor that is not only important in neuronal development and plasticity but also impacts endothelial angiogenesis, cell migration, tumor growth and the production of antibodies by B cells.
Georgia Papadogianni +6 more
doaj +1 more source
Leukemia Research Reports, 2022 The use of monoclonal antibodies represents an important and efficient diagnostic and therapeutic tool in disease management and modern science but remains limited by several factors including the uneven distribution in diseased tissues as well as ...
Sami El Khatib, Mohamed Salla
doaj +1 more source
Radioimmunotherapy of lymphoma [PDF]
Archive of Oncology, 2012 Radiolabeled monoclonal antibodies for the treatment of follicular low-grade non-Hodgkin’s lymphoma have been available for several years in the United States and more recently throughout Europe.
Goldsmith Stanley J.
doaj +1 more source
Nature Communications, 2021 Although enterovirus D68 poses a major global threat to children, neither vaccines nor therapeutics are currently available. Using Cryo-EM, Zhang et al.
Chao Zhang +10 more
doaj +1 more source
Progress on Phage Display Technology: Tailoring Antibodies for Cancer Immunotherapy
Viruses, 2023 The search for innovative anti-cancer drugs remains a challenge. Over the past three decades, antibodies have emerged as an essential asset in successful cancer therapy.
Renato Kaylan Alves França +7 more
doaj +1 more source
Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies
Cell Reports, 2021 Summary: An effective HIV-1 vaccine will likely need to elicit broadly neutralizing antibodies (bNAbs). Broad and potent VRC01-class bNAbs have been isolated from multiple infected individuals, suggesting that they could be reproducibly elicited by ...
Emilie Seydoux +13 more
doaj +1 more source