Results 11 to 20 of about 2,469,529 (358)

The Latest Battles Between EGFR Monoclonal Antibodies and Resistant Tumor Cells

Frontiers in Oncology, 2020
Epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor involved in homeostatic regulation of normal cells and carcinogenesis of epithelial malignancies.
Wen-Qi Cai, Wen-Qi Cai, Li-Si Zeng, Li-Feng Wang, Ying-Ying Wang, Ying-Ying Wang, Jun-Ting Cheng, Jun-Ting Cheng, Ying Zhang, Ying Zhang, Zi-Wen Han, Zi-Wen Han, Yang Zhou, Yang Zhou, Shao-Li Huang, Xian-Wang Wang, Xian-Wang Wang, Xiao-Chun Peng, Xiao-Chun Peng, Ying Xiang, Ying Xiang, Zhaowu Ma, Zhaowu Ma, Shu-Zhong Cui, Hong-Wu Xin, Hong-Wu Xin   +25 more
doaj   +2 more sources

Pharmacokinetics of Monoclonal Antibodies

CPT: Pharmacometrics & Systems Pharmacology, 2017
Monoclonal antibodies (mAbs) have developed in the last two decades into the backbone of pharmacotherapeutic interventions in a variety of indications, with currently more than 40 mAbs approved by the US Food and Drug Administration, and several dozens more in clinical development. This tutorial will review major drug disposition processes relevant for
Bernd Meibohm, Josiah T. Ryman
openaire   +4 more sources

MONOCLONAL ANTIBODIES

Hematology, Transfusion and Cell Therapy
Obinutuzumab, an anti CD-20 monoclonal antibody, can be used in combination with venetoclax, ibrutinib or acalabrutinib in CLL patients with newly diagnosed or relaps patient's treatment indications. Another anti CD-20 monoclonal antibody, rituximab, has been used in combination with bendamustine, FC in del 17p/tp53 negative, ig H mutated patients in ...
Zekeriya Aksöz
openaire   +3 more sources

Extreme Point Sort Transformation Combined With a Long Short-Term Memory Network Algorithm for the Raman-Based Identification of Therapeutic Monoclonal Antibodies

Frontiers in Chemistry, 2022
Therapeutic monoclonal antibodies (mAbs) are a new generation of protein-based medicines that are usually expensive and thus represent a target for counterfeiters.
Jin Ling, Luxia Zheng, Mingming Xu, Gang Chen, Xiao Wang, Danzhuo Mao, Hong Shao   +6 more
doaj   +1 more source

Identification, Efficacy, and Stability Evaluation of Succinimide Modification With a High Abundance in the Framework Region of Golimumab

Frontiers in Chemistry, 2022
Succinimide (Asu) is the intermediate for asparagine deamidation in therapeutic proteins, and it can be readily hydrolyzed to form aspartate and iso-aspartate residues. Moreover, Asu plays an important role in the protein degradation pathways, asparagine
Tao Liu, Tao Liu, Tao Liu, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Qingcheng Guo, Dapeng Zhang, Dapeng Zhang, Dapeng Zhang, Jun Li, Weizhu Qian, Weizhu Qian, Weizhu Qian, Huaizu Guo, Huaizu Guo, Huaizu Guo, Huaizu Guo, Xinli Zhou, Sheng Hou, Sheng Hou, Sheng Hou   +22 more
doaj   +1 more source

Neutralizing monoclonal antibodies for treatment of COVID-19

Nature reviews. Immunology, 2021
Several neutralizing monoclonal antibodies (mAbs) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed and are now under evaluation in clinical trials.
P. Taylor, A. Adams, M. Hufford, I. de la Torre, K. Winthrop, R. Gottlieb   +5 more
semanticscholar   +1 more source

Identification of Immunogenic Linear B-Cell Epitopes in C. burnetii Outer Membrane Proteins Using Immunoinformatics Approaches Reveals Potential Targets of Persistent Infections

Pathogens, 2021
Coxiella burnetii is a global, highly infectious intracellular bacterium, able to infect a wide range of hosts and to persist for months in the environment. It is the etiological agent of Q fever—a zoonosis of global priority.
Sílvia da Silva Fontes, Fernanda de Moraes Maia, Laura Santa’Anna Ataides, Fernando Paiva Conte, Josué da Costa Lima-Junior, Tatiana Rozental, Matheus Ribeiro da Silva Assis, Adonai Alvino Pessoa Júnior, Jorlan Fernandes, Elba Regina Sampaio de Lemos, Rodrigo Nunes Rodrigues-da-Silva   +10 more
doaj   +1 more source

Reaction of Human Monoclonal Antibodies to SARS-CoV-2 Proteins With Tissue Antigens: Implications for Autoimmune Diseases

Frontiers in Immunology, 2021
We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause.
A. Vojdani, E. Vojdani, Datis Kharrazian
semanticscholar   +1 more source

The Serological Cross-Detection of Bat-Borne Hantaviruses: A Valid Strategy or Taking Chances?

Viruses, 2021
Bats are hosts of a range of viruses, and their great diversity and unique characteristics that distinguish them from all other mammals have been related to the maintenance, evolution, and dissemination of these pathogens.
Renata Carvalho de Oliveira, Jorlan Fernandes, Elba Regina de Sampaio Lemos, Fernando de Paiva Conte, Rodrigo Nunes Rodrigues-da-Silva   +4 more
doaj   +1 more source

SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies

Nature, 2021
Transmission of SARS-CoV-2 is uncontrolled in many parts of the world; control is compounded in some areas by the higher transmission potential of the B.1.1.7 variant1, which has now been reported in 94 countries.
D. Collier, A. De Marco, I. Ferreira, B. Meng, R. Datir, A. Walls, Steven A Kemp S, J. Bassi, D. Pinto, C. Fregni, S. Bianchi, M. A. Tortorici, John E. Bowen, K. Culap, S. Jaconi, E. Cameroni, G. Snell, M. Pizzuto, A. F. Pellanda, C. Garzoni, A. Riva, A. Elmer, N. Kingston, B. Graves, Laura E. McCoy, Kenneth G. C. Smith, J. Bradley, Nigel James Temperton, L. Lourdes Ceron-Gutierrez, G. Barcenas-Morales, William T. Harvey, H. Virgin, A. Lanzavecchia, L. Piccoli, R. Doffinger, M. Wills, D. Veesler, D. Corti, Ravindra K. Gupta   +38 more
semanticscholar   +1 more source