Results 11 to 20 of about 2,156,166 (288)

Helix Matrix Transformation Combined With Convolutional Neural Network Algorithm for Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry-Based Bacterial Identification

Frontiers in Microbiology, 2020
Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) analysis is a rapid and reliable method for bacterial identification.
Jin Ling, Jin Ling, Gaomin Li, Gaomin Li, Hong Shao, Hong Shao, Hong Wang, Hong Wang, Hongrui Yin, Hongrui Yin, Hu Zhou, Yufei Song, Gang Chen, Gang Chen   +13 more
doaj   +1 more source

A Novel Anti-CD73 Antibody That Selectively Inhibits Membrane CD73 Shows Antitumor Activity and Induces Tumor Immune Escape

Biomedicines, 2022
CD73 catalyzes the conversion of ATP to adenosine, which is involved in various physiological and pathological processes, including tumor immune escape.
Markus Kellner, Bettina von Neubeck, Bastian Czogalla, Regina Feederle, Binje Vick, Irmela Jeremias, Reinhard Zeidler   +6 more
doaj   +1 more source

Monoclonal Antibodies as Neurological Therapeutics

Pharmaceuticals, 2021
Over the last 30 years the role of monoclonal antibodies in therapeutics has increased enormously, revolutionizing treatment in most medical specialties, including neurology.
Panagiotis Gklinos, Miranta Papadopoulou, Vid Stanulovic, Dimos D. Mitsikostas, Dimitrios Papadopoulos   +4 more
doaj   +1 more source

Monoclonal Antibodies in Cancer Therapy

Antibodies, 2020
Monoclonal antibody-based immunotherapy is now considered to be a main component of cancer therapy, alongside surgery, radiation, and chemotherapy. Monoclonal antibodies possess a diverse set of clinically relevant mechanisms of action.
D. Zahavi, L. Weiner
semanticscholar   +1 more source

Human monoclonal antibodies and monoclonal antibody multispecificity [PDF]

British Journal of Cancer, 1987
The majority of human anti-tumour monoclonal antibodies (Mabs) isolated to date have been disappointing. Firstly, they react or cross react with intracellular cytoskeletal proteins or nuclear antigens and therefore are of limited value as blood borne agents.
A M, Campbell, P, Whitford, R E, Leake
openaire   +2 more sources

Broad neutralization of SARS-related viruses by human monoclonal antibodies

Science, 2020
Seeking broad protection As scientists develop therapeutic antibodies and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the risk of emergent coronaviruses makes it important to also identify broadly protective antibodies.
Anna Z. Wec, D. Wrapp, A. Herbert, Daniel P. Maurer, Denise Haslwanter, M. Sakharkar, R. Jangra, M. Dieterle, A. Lilov, Deli Huang, Longping V. Tse, N. Johnson, C. Hsieh, Nianshuang Wang, J. Nett, E. Champney, Irina Burnina, Michael E. Brown, Shu Lin, M. Sinclair, Carl Johnson, Sarat Pudi, R. Bortz, A. Wirchnianski, Ethan Laudermilch, Catalina Florez, J. Fels, Cecilia M. O’Brien, B. Graham, D. Nemazee, D. Burton, R. Baric, J. Voss, K. Chandran, J. Dye, J. McLellan, L. Walker   +36 more
semanticscholar   +1 more source

Monoclonal Antibodies for Prevention and Treatment of COVID-19.

Journal of the American Medical Association (JAMA), 2020
The coronavirus disease 2019 (COVID-19) pandemic has created a worldwide crisis and inspired an urgent search for prevention and treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Attention has focused on the development
M. Marovich, J. Mascola, M. Cohen
semanticscholar   +1 more source

Delineating Molecular Mechanisms of Squamous Tissue Homeostasis and Neoplasia: Focus on p63

Journal of Skin Cancer, 2013
Mouse models have informed us that p63 is critical for normal epidermal development and homeostasis. The p53/p63/p73 family is expressed as multiple protein isoforms due to a combination of alternative promoter usage and C-terminal alternative splicing ...
Kathryn E. King, Linan Ha, Tura Camilli, Wendy C. Weinberg   +3 more
doaj   +1 more source

Hybridoma technology; advancements, clinical significance, and future aspects

Journal of Genetic Engineering and Biotechnology, 2021
Background Hybridoma technology is one of the most common methods used to produce monoclonal antibodies. In this process, antibody-producing B lymphocytes are isolated from mice after immunizing the mice with specific antigen and are fused with immortal ...
Sanchita Mitra, Pushpa Chaudhary Tomar
doaj   +1 more source

CH2 Domain of Mouse IgG3 Governs Antibody Oligomerization, Increases Functional Affinity to Multivalent Antigens and Enhances Hemagglutination

Frontiers in Immunology, 2018
Mouse IgG3 is highly protective against several life-threatening bacteria. This isotype is the only one among mouse IgGs that forms non-covalent oligomers, has increased functional affinity to polyvalent antigens, and efficiently agglutinates ...
Tomasz Klaus, Tomasz Klaus, Joanna Bereta   +2 more
doaj   +1 more source