Results 211 to 220 of about 2,469,529 (358)

Electrostatics and viscosity are strongly linked in concentrated antibody solutions [PDF]

arXiv
Monoclonal antibodies are among the most promising therapeutic agents in modern medicine, yet their formulation into high-concentration solutions for subcutaneous self-administration poses a major challenge. A key obstacle is the marked increase in viscosity often observed under these conditions.
arxiv  

Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response

Advanced Healthcare Materials, EarlyView.
In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim, Jin Woong Lee, Piper A. Rawding, Mari Iida, Carter Kim, Kourtney L. Kostecki, Michael J. Poellmann, Bridget Crossman, Ashley S. Liu, YoungSoo Kim, Deric L. Wheeler, Seungpyo Hong   +11 more
wiley   +1 more source

Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).

Journal of Histochemistry and Cytochemistry, 1984
J. Cordell, B. Falini, W. Erber, A. Ghosh, Zainalabideen Abdulaziz, S. Macdonald, K. Pulford, H. Stein, D. Mason   +8 more
semanticscholar   +1 more source

Effect of Nanoparticle Rigidity on the Interaction of Stromal Membrane Particles with Leukemia Cells

Advanced Healthcare Materials, EarlyView.
Cell membrane nanoparticles made with stromal cells are prepared and used to target leukemia cells. Deposition of the cell membrane onto rigid silica cores leads to increased uptake both in leukemia cell lines and primary cells from patients. These results show that nanoparticle rigidity affects the interaction between cell membrane nanoparticles and ...
Sander de Weerd, Xinyu Ma, Zahra Zohali, Lieve L. Oudejans, Emmanouil Kyrloglou, Marc. C. A. Stuart, Wouter H. Roos, Jan Jacob Schuringa, Anna Salvati   +8 more
wiley   +1 more source

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

Nature, 2021
E. Cameroni, John E. Bowen, Laura E. Rosen, C. Saliba, Samantha K. Zepeda, K. Culap, D. Pinto, L. VanBlargan, A. De Marco, J. di Iulio, F. Zatta, Hannah Kaiser, Julia Noack, Nisar Farhat, N. Czudnochowski, C. Havenar-Daughton, Kaitlin R. Sprouse, J. Dillen, Abigail E. Powell, Alex K Chen, Cyrus Maher, Li Yin, David Sun, Leah B. Soriaga, J. Bassi, C. Silacci-Fregni, C. Gustafsson, N. Franko, J. Logue, N. Iqbal, I. Mazzitelli, J. Geffner, R. Grifantini, H. Chu, A. Gori, A. Riva, O. Giannini, A. Ceschi, P. Ferrari, Pietro E. Cippà, A. Franzetti-Pellanda, C. Garzoni, P. Halfmann, Y. Kawaoka, C. Hebner, L. Purcell, L. Piccoli, M. Pizzuto, A. Walls, M. Diamond, A. Telenti, H. Virgin, A. Lanzavecchia, G. Snell, D. Veesler, D. Corti   +55 more
semanticscholar   +1 more source

Immunosuppressive Cytokine‐Tethered Hydrogel for Treating Rheumatoid Arthritis

Advanced Healthcare Materials, EarlyView.
An injectable hydrogel is developed by chemically tethering IL‐4, an immunosuppressive cytokine, to a hyaluronic acid‐based backbone. The hydrogel reduces joint friction and exerts immunomodulatory effects. In a rheumatoid arthritis (RA) mouse model, it reduced inflammation, preserved cartilage, and promoted anti‐inflammatory immune responses.
Woojin Back, Moonkyoung Jeong, Huyen‐Thao Le, Ji‐Ho Park   +3 more
wiley   +1 more source

Advances in Photonic Materials and Integrated Devices for Smart and Digital Healthcare: Bridging the Gap Between Materials and Systems

Advanced Materials, EarlyView.
This article summarizes significant technological advancements in materials, photonic devices, and bio‐interfaced systems, which demonstrate successful applications for impacting human healthcare via improved therapies, advanced diagnostics, and on‐skin health monitoring.
Seunghyeb Ban, Hoon Yi, Jaejin Park, Yunuo Huang, Ki Jun Yu, Woon‐Hong Yeo   +5 more
wiley   +1 more source

Застосування моноклональних антитіл у лікуванні пацієнтів з хронічними лімфопроліферативними захворюваннями

, 2000
У статті узагальнені сучасні можливості застосування препаратів кон’югованих та некон’югованих моноклональних антитіл у лікуванні пацієнтів з хронічними лімфопроліферативними захворюваннями. Проведено порівняльний аналіз принципів та механізмів їх дії та
Матлан, В.Л.
core  

Machine‐Learning‐Aided Advanced Electrochemical Biosensors

Advanced Materials, EarlyView.
Electrochemical biosensors are highly sensitive, portable, and versatile. Advanced nanomaterials enhance their performance, while machine learning (ML) improves data analysis, minimizes interference, and optimizes sensor design. Despite progress in both fields, their combined potential in diagnostics remains underexplored.
Andrei Bocan, Roozbeh Siavash Moakhar, Carolina del Real Mata, Max Petkun, Tristan De Iure‐Grimmel, Sripadh Guptha Yedire, Hamed Shieh, Arash Khorrami Jahromi, Sahar Sadat Mahshid, Sara Mahshid   +9 more
wiley   +1 more source

Flexible 3D Kirigami Probes for In Vitro and In Vivo Neural Applications

Advanced Materials, EarlyView.
A customizable and scalable approach to fabricate flexible 3D kirigami microelectrode arrays (MEAs) featuring up to 128 shanks, including surface and penetrating electrodes designed to interact with the 3D space of neural tissue, is presented. The 3D kirigami MEAs are successfully deployed in several neural applications, both in vitro and in vivo, and ...
Marie Jung, Jamal Abu Shihada, Simon Decke, Lina Koschinski, Peter Severin Graff, Sebastián Maruri Pazmino, Anke Höllig, Henner Koch, Simon Musall, Andreas Offenhäusser, Viviana Rincón Montes   +10 more
wiley   +1 more source