Results 1 to 10 of about 570,434 (333)

A nanowell platform to identify, sort and expand high antibody-producing cells [PDF]

Scientific Reports
Increased use of therapeutic monoclonal antibodies and the relatively high manufacturing costs fuel the need for more efficient production methods. Here we introduce a novel, fast, robust, and safe isolation platform for screening and isolating antibody ...
Fikri Abali, Richard Schasfoort, Sanne Nijland, Jelle Wittenberns, Arjan. G. J. Tibbe, Marcel den Hartog, Louis Boon, Leon W. M. M. Terstappen   +7 more
doaj   +2 more sources

STUDIES ON ANTIBODY-PRODUCING CELLS [PDF]

The Journal of Experimental Medicine, 1970
Efferent lymph of the popliteal lymph nodes of rabbits was collected 4 days after a single footpad injection of SRBC. Thin-layer agar plating was done to isolate plaque-forming cells of the lymph for electron microscope examination, and the numbers of plaque-forming cells (PFC) in cells from the lymph and lymph nodes were determined.
Fred G. Gudat, T. N. Harris, Susanna Harris, Klaus Hummeler   +3 more
openaire   +6 more sources

Disulfiram treatment suppresses antibody-producing reactions by inhibiting macrophage activation and B cell pyrimidine metabolism [PDF]

Communications Biology
Antibody responses, involving B cells, CD4 + T cells, and macrophages, are implicated in autoimmune diseases and organ transplant rejection. We have previously shown that inhibiting FROUNT with disulfiram (DSF) suppresses macrophage activation and ...
Weili Chen, Etsuko Toda, Kazuhiro Takeuchi, Yurika Sawa, Kyoko Wakamatsu, Naomi Kuwahara, Arimi Ishikawa, Yuri Igarashi, Mika Terasaki, Shinobu Kunugi, Yasuhiro Terasaki, Kazuhiko Yamada, Yuya Terashima, Akira Shimizu   +13 more
doaj   +2 more sources

Polyfunctional T peripheral helper cells are associated with the magnitude and durability of antibody responses after COVID‐19 [PDF]

Clinical & Translational Immunology
Objective Examine the role of T cells in shaping and sustaining humoral immunity to SARS‐CoV‐2 and identify immune factors associated with durable antibody responses.
Katie Tungatt, Gabriela Martins Costa Gomes, Nicole L Fewings, Aija Stubis, Chloe M Doyle, Vera Merheb, Anupriya Aggarwal, Karen Byth, Harry Robertson, Suat Dervish, Susan Maddocks, Janette Taylor, Rowena A Bull, Marianne Martinello, the COSIN Protocol Steering Committee, Fabienne Brilot, Stuart G Turville, Anthony L Cunningham, Kerrie J Sandgren   +18 more
doaj   +2 more sources

IgG4 Autoantibodies in Organ-Specific Autoimmunopathies: Reviewing Class Switching, Antibody-Producing Cells, and Specific Immunotherapies. [PDF]

Front Immunol, 2022
Koneczny I, Tzartos J, Mané-Damas M, Yilmaz V, Huijbers MG, Lazaridis K, Höftberger R, Tüzün E, Martinez-Martinez P, Tzartos S, Leypoldt F.   +10 more
europepmc   +3 more sources

Early Interferon-γ Production in Human Lymphocyte Subsets in Response to Nontyphoidal Salmonella Demonstrates Inherent Capacity in Innate Cells [PDF]

, 2010
Background Nontyphoidal Salmonellae frequently cause life-threatening bacteremia in sub-Saharan Africa. Young children and HIV-infected adults are particularly susceptible.
Anna E. Seeley, Calman A. MacLennan, Derya Unutmaz, Mark T. Drayson, Tonney S. Nyirenda, Wilson L. Mandala   +5 more
core   +15 more sources

FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis

Cells, 2022
Antibodies are central effectors of the adaptive immune response, widespread used therapeutics, but also potentially disease-causing biomolecules. Antibody folding catalysts in the plasma cell are incompletely defined. Idiopathic pulmonary fibrosis (IPF)
Stefan Preisendörfer, Yoshihiro Ishikawa, Elisabeth Hennen, Stephan Winklmeier, Jonas C. Schupp, Larissa Knüppel, Isis E. Fernandez, Leonhard Binzenhöfer, Andrew Flatley, Brenda M. Juan-Guardela, Clemens Ruppert, Andreas Guenther, Marion Frankenberger, Rudolf A. Hatz, Nikolaus Kneidinger, Jürgen Behr, Regina Feederle, Aloys Schepers, Anne Hilgendorff, Naftali Kaminski, Edgar Meinl, Hans Peter Bächinger, Oliver Eickelberg, Claudia A. Staab-Weijnitz   +23 more
doaj   +1 more source

The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells

Immunity & Ageing, 2022
Background Memory B cells are an antigen-experienced B-cell population with the ability to rapidly differentiate into antibody-producing cells by recall responses.
Yuma Sugiyama, Mitsuhiro Fujiwara, Akihiko Sakamoto, Hiromichi Tsushima, Akihiko Nishikimi, Mitsuo Maruyama   +5 more
doaj   +1 more source

Detection of circulating B cells producing anti-GPIb autoantibodies in patients with immune thrombocytopenia. [PDF]

PLoS ONE, 2014
BACKGROUND: We previously reported that an enzyme-linked immunospot (ELISPOT) assay for detecting anti-GPIIb/IIIa antibody-secreting B cells is a sensitive method for identifying patients with immune thrombocytopenia (ITP).
Masataka Kuwana, Yuka Okazaki, Yasuo Ikeda   +2 more
doaj   +1 more source

Introduction of direct-acting antiviral agents alters frequencies of anti-GPIIb/IIIa antibody-producing B cells in chronic hepatitis C patients with thrombocytopenia

Platelets, 2023
The pathogenesis of thrombocytopenia in chronic hepatitis C (CHC) conceivably involves autoimmunity; however, the dynamics of autoantibodies and other autoimmune mechanisms remain unclear.
Takashi Satoh, Haruki Uojima, Naohisa Wada, Hayato Takiguchi, Mei Kaneko, Marina Nakamura, Natsuki Gonda, Michika Homma, Hisashi Hidaka, Chika Kusano, Ryouichi Horie   +10 more
doaj   +1 more source