Results 101 to 110 of about 583,416 (296)

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Regulatory considerations in the design, development and quality of monoclonal antibodies and related products for the diagnosis and treatment of cancer

Frontiers in Oncology
Over 160 therapeutic and in vivo diagnostic monoclonal antibodies have been approved by the US FDA since the first monoclonal antibody, muromonab, was approved in 1986.
Marjorie A. Shapiro
doaj   +1 more source

Antibody isotypes, including IgG subclasses, in Ecuadorian patients with pulmonary Paragonimiasis

Memorias do Instituto Oswaldo Cruz, 1995
An ELISA test was developed to detect Paragonimus-specific antibodies, including IgG subclasses, using P. mexicanus crude water-soluble antigens. The test was standardized to detect antibodies in sera of Ecuadorian patients with pulmonary paragonimiasis ...
Angel Guevara E., Juan Carlos Vieira G., Edmundo Araujo N., Manuel Calvopiña H., Ronald H. Guderian, Yves Carlier   +5 more
doaj   +1 more source

Epstein-Barr virus but not cytomegalovirus is associated with reduced vaccine antibody responses in Gambian infants. [PDF]

, 2010
BACKGROUND: Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are persistent herpesviruses that have various immunomodulatory effects on their hosts. Both viruses are usually acquired in infancy in Sub-Saharan Africa, a region where childhood vaccines ...
Ebrima S Touray, Whittle, H., Miles David J. C., Kaye, Steve, Melba S Palmero, Roberts, E., Ojuola, Olubukola, Palmero Melba S., Ojuola, O, Kaye Steve, Duah, NO, Mohammed, N.I., Cotten, M., Marianne van der Sande, Waight Pauline, Rowland-Jones, S., Cotten, M, Touay, Ebrima S., Holder, B., Cotten Matthew, Mohammed, NI, van der Sande Marianne, Whittle, H, Crozier, Sarah, Roberts, Elishia, Rowland-Jones, Sarah, Crozier, S., Miles, David J.C., Palmero, Melba S., Ojuola Olubukola, Waight, P., Touray, ES, Beth Holder, Roberts Elishia, Nuredin Ibrahim Mohammed, Nancy O Duah, Sarah Crozier, Touray, E.S., Hilton Whittle, Mohammed, Nuredin Ibrahim, Elishia Roberts, Sarah Rowland-Jones, Ebrima S. Touray, Touray, Ebrima S, van der Sande, M., Nancy O. Duah, Matthew Cotten, Whittle Hilton, Miles, David J C, Steve Kaye, Miles, David JC, van der Sande, Marianne, Kaye, S, Ojuola, O., David J C Miles, Mohammed Nuredin Ibrahim, Holder Beth, Palmero, M.S., Duah Nancy O., Melba S. Palmero, Cotten, Matthew, Duah, Nancy O, Palmero, Melba S, Whittle, Hilton, Miles, DJC, Rowland-Jones Sarah, Miles, D.J., Kaye, S., Holder, B, Olubukola Ojuola, David J. C. Miles, Touray Ebrima S., Duah, Nancy O., Palmero, MS, Duah, N.O., Waight, Pauline, Roberts, E, Rowland-Jones, S, Holder, Beth, Waight, P, Crozier, S, Pauline Waight, Crozier Sarah, Van der Sande, M   +83 more
core   +1 more source

Multiplexed Profiling of Individual Extracellular Vesicles Reveals Lung Cancer‐Associated Protein Signatures

Advanced Science, EarlyView.
Cygnus (Cyclic‐imaging gateway to nanovesicles underlying signature) integrates multiplexed single‐EV protein imaging with a practical analysis workflow to examine EV phenotypes at vesicle, subpopulation, and sample scales. ABSTRACT Lung cancer is frequently diagnosed after curative treatment windows have narrowed, creating a need for minimally ...
Mi Hyeon Cho, Yein Chung, Yoonjeong Choi, Baekdong Cha, Jayeon Song, Nuri Oh, Ala Jo, Thomas S. C. Ng, Hyunho Kim, Hyun‐Kyung Woo, Chang Hyun Kim, Cesar M. Castro, Miles A. Miller, Hakho Lee   +13 more
wiley   +1 more source

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source

Can anti-PGL-I antibody isotypes differentiate leprosy contacts and leprosy patients? [PDF]

Pathog Glob Health, 2022
Albuquerque AA, Dos Santos Mateus C, de Oliveira Rodrigues R, Lima ÉS, Lima LO, da Silva RL, Fernandes MAM, de Macedo AC, Tavares CM, Nogueira PSF, Nagao-Dias AT.   +10 more
europepmc   +1 more source

IgG isotypes and IgA antibody levels in M. coucha.

, 2013
IgG isotypes and IgA antibody levels were measured at 30, 60, 180 day post-challenge in all the three groups. (A) High levels of IgG1, (B) IgG2a, (C) IgG2b and (D) IgA antibodies were found at all time points. Bars represent the mean ± S.E (n = 13).
Shailja Misra-Bhattacharya (191184), Susheela Kushwaha (311547), Prashant Kumar Singh (136953), Ajay Kumar Rana (451285)   +3 more
core   +1 more source

CHST1 Drives Immunotherapy Resistance in Triple‐Negative Breast Cancer by Orchestrating an Immunosuppressive Microenvironment via the NKRF–CCL20–Macrophage Axis

Advanced Science, EarlyView.
Proposed model of CHST1‐associated immune remodeling in triple‐negative breast cancer. In CHST1‐low tumors, greater nuclear accumulation of NKRF is associated with repression of an NF‐κB‐related CCL20 transcriptional program and an immune‐inflamed microenvironment.
Shu‐Hao Jiang, Xiao‐Han Ying, Ruo‐Qing Wang, Qun Zhang, Li Chen, Zhi‐Ming Shao, Jun‐Jie Li   +6 more
wiley   +1 more source

CONTENTS DIPHTHERIA ANTITOXIC AND ANTIBACTERIAL ANTIBODIES IN THE SERUM OF HEALTHY ADULTS

Acta Biomedica Scientifica, 2012
In the article using the binomial distribution analysis of the intensity of рориlation antitoxic (AT) and antibacterial (AB) of immunity to diphtheria in terms of specific diphtheria antibodies in the sera of healthy adults aged 20 to 51 years and. older,
E. A. Shmeleva, S. M. Popkova, T. N. Flrsova, E. B. Rakova, L. V. Serdyuk, M. M. Gubin   +5 more
doaj