Results 61 to 70 of about 583,416 (296)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Competition between serum IgG, IgM, and IgA anti-glycan antibodies. [PDF]

PLoS ONE, 2015
Anti-glycan antibodies are an abundant subpopulation of serum antibodies with critical functions in many immune processes. Changes in the levels of these antibodies can occur with the onset of disease, exposure to pathogens, or vaccination.
Saddam M Muthana, Li Xia, Christopher T Campbell, Yalong Zhang, Jeffrey C Gildersleeve   +4 more
doaj   +1 more source

Apoptosis induction potential of different Rituximab isotypes and antibody fragments.

, 2016
The absolute apoptotic induction of different Rituximab isotypes and antibody fragments is shown; full length sequences, numerical values and p-values can be found in the supplemental information.
Annette Sieron (841275), Jennifer D. Könitzer (841274), Barbara Enenkel (841277), Angelika Wacker (841276)   +3 more
core   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Anti-dsDNA antibody isotypes in systemic lupus erythematosus: IgA in addition to IgG anti-dsDNA help to identify glomerulonephritis and active disease. [PDF]

PLoS ONE, 2013
OBJECTIVES: To evaluate the role of serum IgG, IgM and IgA anti-dsDNA antibody isotypes in the diagnosis of systemic lupus erythematosus (SLE), and their association with clinical features and disease activity, in a large cohort of SLE patients. METHODS:
Danilo Villalta, Nicola Bizzaro, Nicola Bassi, Margherita Zen, Mariele Gatto, Anna Ghirardello, Luca Iaccarino, Leonardo Punzi, Andrea Doria   +8 more
doaj   +1 more source

Additional file 4: of Association between different anti-Tat antibody isotypes and HIV disease progression: data from an African cohort

, 2016
Prospective analysis of the association of different anti-Tat antibody isotypes with T cell subpopulations. Subjects were stratified according the type and number of anti-Tat antibody isotypes. Bars show the proportion of the different subsets in the CD8+
Mkunde Chachage (543774), Elmar Saathoff (4991), Christof Geldmacher (317649), Francesco Nicoli (479695), Leonard Maboko (175605), Michael Hoelscher (151418), Riccardo Gavioli (51633), Asli Bauer (543776), Dickens Kowour (543778), Aurelio Cafaro (120021), Petra Clowes (175598), Barbara Ensoli (120173)   +11 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Cytokine and Antibody Isotype Responses in Vaccinated Healthcare Workers with SARS-CoV-2 Breakthrough Infections

Viruses
Background: Healthcare workers (HCWs) are at high risk of breakthrough SARS-CoV-2 infections despite complete vaccination schedules. There are gaps in our understanding of the specific antibody isotypes and cytokine profiles produced during an infection ...
Miguel Ángel Fernández-Rojas, Tanya Plett-Torres, Guillermina Ávila, Mirza Romero-Valdovinos, Ana María Salazar, Monserrat Sordo, Mariana Chávez-Vargas, Cesar Josué Coeto Ángeles, Mayra Cruz-Rivera, Carlos Santiago-Olivares, Juan Pablo Ramírez Hinojosa, Pablo Maravilla, Patricia Ostrosky-Wegman, Fela Mendlovic, Ana Flisser   +14 more
doaj   +1 more source

The Characterization of Disease Severity Associated IgG Subclasses Response in COVID-19 Patients

Frontiers in Immunology, 2021
Increasing evidence suggests that dysregulated immune responses are associated with the clinical outcome of coronavirus disease 2019 (COVID-19). Nucleocapsid protein (NP)-, spike (S)-, receptor binding domain (RBD)- specific immunoglobulin (Ig) isotypes,
Huanle Luo, Huanle Luo, Tingting Jia, Jiamin Chen, Shike Zeng, Zengzhao Qiu, Shu Wu, Xu Li, Yuxuan Lei, Xin Wang, Weihua Wu, Renli Zhang, Xuan Zou, Tiejian Feng, Ruxia Ding, Yue Zhang, Yao-Qing Chen, Yao-Qing Chen, Caijun Sun, Caijun Sun, Tian Wang, Tian Wang, Tian Wang, Shisong Fang, Yuelong Shu, Yuelong Shu   +25 more
doaj   +1 more source

Analysis of antibody isotypes from a single subject.

, 2022
(a) Example trees visualized using ggtree [38,39] showing observed relationships between cells expressing BCRs with IgA1 and IgE, as well as IgG1 and IgG4 isotypes. IgE and IgG4 are indicated on each tree using larger tip circles.
Oliver G. Pybus (8098271), Steven H. Kleinstein (8219844), Kenneth B. Hoehn (3259305)   +2 more
core   +1 more source