Antigen-specific antibody isotypes of mice vaccinated with Protein A by s/c or i/mam routes.
, 2016 Antigen-specific antibody isotypes of mice vaccinated with Protein A by s/c or i/mam routes.
Sangeetha Mathavan (849736) +6 more
core +1 more source
Signaling control of antibody isotype switching
, 2019 Class switch recombination (CSR) generates isotype-switched antibodies with distinct effector functions essential for mediating effective humoral immunity. CSR is catalyzed by activation-induced deaminase (AID) that initiates DNA lesions in the evolutionarily conserved switch (S) regions at the immunoglobulin heavy chain (Igh) locus.
Zhangguo, Chen, Jing H, Wang
openaire +3 more sources
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Unique antibody responses to malondialdehyde-acetaldehyde (MAA)-protein adducts predict coronary artery disease. [PDF]
PLoS ONE, 2014 Malondialdehyde-acetaldehyde adducts (MAA) have been implicated in atherosclerosis. The purpose of this study was to investigate the role of MAA in atherosclerotic disease.
Daniel R Anderson +10 more
doaj +1 more source
Isotype specific ELISAs to detect antibodies against swine vesicular disease virus and their use in epidemiology [PDF]
, 2002 Isotype specific ELISAs to detect antibodies against swine vesicular disease, which may help to estimate the moment of infection, were developed and validated on sera from pigs experimentally infected with four different isolates of swine vesicular ...
Dekker, A. +3 more
core +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Heritability of antibody isotype and subclass responses to Plasmodium falciparum antigens.
PLoS ONE, 2009 BackgroundIt is important to understand the extent to which genetic factors regulate acquired immunity to common infections. A classical twin study design is useful to estimate the heritable component of variation in measurable immune parameters ...
Nancy O Duah +5 more
doaj +1 more source
Generation and characterization of antibodies against Asian elephant (Elephas maximus) IgG, IgM, and IgA. [PDF]
PLoS ONE, 2015 Asian elephant (Elephas maximus) immunity is poorly characterized and understood. This gap in knowledge is particularly concerning as Asian elephants are an endangered species threatened by a newly discovered herpesvirus known as elephant ...
Alan F Humphreys +9 more
doaj +1 more source
Distribution of B cell subsets and antibody isotypes within clonal families.
, 2023 Graphs depict the number of antibodies encoded (A) by distinct B cell subsets and (B) as various isotypes in clonal families of different sizes in each of the four donor samples analyzed.
Duncan K. Ralph (9248973) +16 more
core +1 more source
Anti-DNA antibody mediated catalysis is isotype dependent [PDF]
Molecular Immunology, 2016 Anti-DNA antibodies are the serological hallmark of systemic lupus erythematosus, and participate in the pathogenesis of lupus nephritis by cross-reacting with multiple renal antigens. Previously, using a panel of murine anti-DNA IgGs that share identical variable regions but that differ in the constant regions, we demonstrated that the cross-reaction ...
Yumin, Xia +4 more
openaire +2 more sources