Results 41 to 50 of about 583,416 (296)

Parameter and variable definitions in Models 1–2 (subscripts for antibody isotypes are not shown).

, 2014
Parameter and variable definitions in Models 1–2 (subscripts for antibody isotypes are not shown).
David J. Topham (175779), Le Zhang (88249), Hulin Wu (392391), Martin S. Zand (623236), Alexandra M. Livingstone (623235), Tim R. Mosmann (158695), Hongyu Miao (526875), Mark Y. Sangster (175782), Shannon P. Hilchey (256584), Jeanne Holden-Wiltse (440496), Alan S. Perelson (140160)   +10 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The potential to improve Lyme disease diagnostics through quantification of immunoglobulin class switching patterns

Journal of Clinical Microbiology
N. Nair, A. Marques , E. J. Horn, G. Brown et al., J Clin Microbiol 63:e0034725, 2025, https://doi.org/10.1128/jcm.00347-25 present data to demonstrate that infection by Borrelia burgdorferi, the primary causative agent of Lyme disease in the USA, leads ...
Anna M. Schotthoefer
doaj   +1 more source

Comparison of anti-PvRAMA antibody isotypes in P. vivax-exposed individuals and malaria-naïve individuals.

, 2016
Comparison of anti-PvRAMA antibody isotypes in P. vivax-exposed individuals and malaria-naïve individuals.
Bo Wang (86769), Chae Seung Lim (1888042), Takafumi Tsuboi (143279), Patchanee Chootong (324563), Eun-Taek Han (620126), Myat Htut Nyunt (1888045), Jin-Hee Han (1314552), Siriruk Changrob (1888039), Seong-Kyun Lee (745055)   +8 more
core   +1 more source

Importance of antibody isotypes in antitumor immunity by monocytes and complement using human-immune tumor models

, 2021
Monoclonal antibodies (mAbs) have revolutionized clinical medicine, especially in the field of cancer immunotherapy. The challenge now is to improve the response rates, as immunotherapy still fails for many patients.
Virtanen, Alexander, Kleinau, Sandra,, Lara, Sandra, Stenhammar, Viktoria,, Kleinau, Sandra, Anania, Jessica,, Viktoria Stenhammar, Sandra Kleinau, Lara, Sandra,, Stenhammar, Viktoria, Virtanen, Alexander,, Sandra Lara, Alexander Virtanen, Anania, Jessica, Jessica C. Anania   +14 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Intracellular neutralisation of rotavirus by VP6-specific IgG.

PLoS Pathogens, 2020
Rotavirus is a major cause of gastroenteritis in children, with infection typically inducing high levels of protective antibodies. Antibodies targeting the middle capsid protein VP6 are particularly abundant, and as VP6 is only exposed inside cells ...
Sarah L Caddy, Marina Vaysburd, Mark Wing, Stian Foss, Jan Terje Andersen, Kevin O'Connell, Keith Mayes, Katie Higginson, Miren Iturriza-Gómara, Ulrich Desselberger, Leo C James   +10 more
doaj   +1 more source

Antibody isotypes/subtypes and antibody-secreting B cells.

, 2013
The antibody isotypes of IgM and IgA and the IgG1, IgG2a, IgG2b and IgG3 subtypes in sera were analyzed using ELISA plates coated with (A) Sf9-rHA or (B) CHO-rHA. Mouse splenocytes were collected 3 wk following second inoculations, and then reacted with (
Suh-Chin Wu (88404), Shih-Chang Lin (319675), Michael Butler (88403), Chi-Huey Wong (63704), Chung-Yi Wu (151759), Jia-Tsrong Jan (422327), Ming-Hsi Huang (322998), Ben Dionne (422328)   +7 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Dual function of eosinophils in pathogenesis and protective immunity against parasites

Memorias do Instituto Oswaldo Cruz, 1992
The functional duality of eosinophils, involved in a protective response or in pathogenesis is illustrated in various parasitic infections. In schistosomiasis, eosinophils have been shown to mediate schistosomula killing, in the presence of antibodies ...
Monique Capron
doaj   +1 more source