Results 21 to 30 of about 583,416 (296)

Assessing the Fc-mediated effector functions on the basis of anti-TNFR2 antibody isotypes [PDF]

, 2022
The advent of monoclonal antibodies (mAbs) has revolutionised the field of immunotherapies and immunodiagnostics. Advancements in antibody engineering have allowed the researchers to fine-tune the antibodies to achieve favourable effects and efficacy ...
Deosthali, Samruddhi
core   +1 more source

Enhanced neutralization potency of an identical HIV neutralizing antibody expressed as different isotypes is achieved through genetically distinct mechanisms

Scientific Reports, 2022
Antibodies with the same variable region can exist as multiple isotypes with varying neutralization potencies, though the mechanism for this is not fully defined.
Thandeka Moyo-Gwete, Cathrine Scheepers, Zanele Makhado, Prudence Kgagudi, Nonkululeko B. Mzindle, Rutendo Ziki, Sharon Madzorera, Nelia P. Manamela, Frances Ayres, Bronwen E. Lambson, Simone I. Richardson, Lynn Morris, Penny L. Moore   +12 more
doaj   +1 more source

Humanization and expression of IgG and IgM antibodies in plants as potential diagnostic reagents for Valley Fever

Frontiers in Plant Science, 2022
Monoclonal antibodies (mAbs) are important proteins used in many life science applications, from diagnostics to therapeutics. High demand for mAbs for different applications urges the development of rapid and reliable recombinant production platforms ...
Collin Jugler, Collin Jugler, Francisca J. Grill, Lukas Eidenberger, Timothy L. Karr, Thomas E. Grys, Herta Steinkellner, Douglas F. Lake, Douglas F. Lake, Qiang Chen, Qiang Chen   +10 more
doaj   +1 more source

Large-scale GWAS meta-analysis of serum antibody levels in healthy individuals reveals distinct genetic architectures. [PDF]

Genes Immun
Antibodies are the principal effector proteins of humoral immunity. Dysregulated antibody production is a feature of a number of heritable immune-mediated diseases, such as the antibody deficiencies and IgA nephropathy. To characterise the common-variant
Willis TW, Gkrania-Klotsas E, Wareham NJ, McKinney EF, Lyons PA, Smith KGC, Wallace C.   +6 more
europepmc   +4 more sources

Acquisition of antibody isotypes against Plasmodium falciparum blood stage antigens in a birth cohort. [PDF]

, 2010
Information on the period during which infants lose their maternally derived antibodies to malaria and begin to acquire naturally their own immune responses against parasite antigens is crucial for understanding when malaria vaccines may be best ...
Duah, NO, D. J. C. MILES, Conway, DJ, N. O. DUAH, Whittle, HC, H. C. WHITTLE, D. J. CONWAY, Miles, DJC   +7 more
core   +1 more source

Effector functions of eosinophils in schistosomiasis

Memorias do Instituto Oswaldo Cruz, 1992
The dual function of eosinophils is clearly illustred in schistosomiasis. Well equipped in membrane receptors for immunoglobulins and complement, and due to the presence of granule basic proteins, eosinophils can become cytotoxic for parasite larvae and ...
Monique Capron, André Capron
doaj   +1 more source

Influence of immunoglobulin isotype on therapeutic antibody function [PDF]

Blood, 2016
AbstractMonoclonal antibody (mAb) therapeutics are revolutionizing cancer treatment; however, not all tumors respond, and agent optimization is essential to improve outcome. It has become clear over recent years that isotype choice is vital to therapeutic success with agents that work through different mechanisms, direct tumor targeting, agonistic ...
Beers, S., Glennie, M., White, A.
openaire   +3 more sources

Levels of antibody isotypes against MtM and Acr in study subjects.

, 2020
Levels of antibody isotypes against MtM and Acr in study subjects.
Amita Aggarwal (5401406), Ramnath Misra (1555531), Shashi Kant Kumar (4632523), Alok Nath (5782718), Sudhir Sinha (635376), Suvrat Arya (5782715), Prerna Kapoor (5782721)   +6 more
core   +1 more source

Characterization of SARS‐CoV‐2 humoral immune response in a subject with unique sampling: A case report

Immunity, Inflammation and Disease, 2023
Background The development of vaccine candidates for COVID‐19, and the administration of booster vaccines, has meant a significant reduction in COVID‐19 related deaths world‐wide and the easing of global restrictions.
Melanie R. Walker, Manja Idorn, Anja Bennett, Max Søgaard, Ali Salanti, Sisse B. Ditlev, Lea Barfod   +6 more
doaj   +1 more source

Effects of gp120 Inner Domain (ID2) Immunogen Doses on Elicitation of Anti-HIV-1 Functional Fc-Effector Response to C1/C2 (Cluster A) Epitopes in Mice

Microorganisms, 2020
Fc-mediated effector functions of antibodies, including antibody-dependent cytotoxicity (ADCC), have been shown to contribute to vaccine-induced protection from HIV-1 infection, especially those directed against non-neutralizing, CD4 inducible (CD4i ...
Rebekah Sherburn, William D. Tolbert, Suneetha Gottumukkala, Guillaume Beaudoin-Bussières, Andrés Finzi, Marzena Pazgier   +5 more
doaj   +1 more source