Antigen-specific influence of GM/KM allotypes on IgG isotypes and association of GM allotypes with susceptibility to
Malaria Journal, 2009 Background Plasmodium falciparum malaria is a complex disease in which genetic and environmental factors influence susceptibility. IgG isotypes are in part genetically controlled, and GM/KM allotypes are believed to be involved in this control.
Theander Thor G +8 more
doaj +2 more sources
Veterinary Immunology and Immunopathology, 1997 Turkey immunoglobulin (Ig) isotypes IgG and IgM were isolated from blood and IgA was isolated from bile. Isolation was accomplished by gel filtration of the ammonium sulphate cut on Sephacryl S-200.
Arnouts, S. +6 more
core +4 more sources
The Crystal Structure of Human IgD-Fc Reveals Unexpected Differences With Other Antibody Isotypes. [PDF]
ProteinsOf the five human antibody isotypes, the function of IgD is the least well-understood, although various studies point to a role for IgD in mucosal immunity. IgD is also the least well structurally characterized isotype.
Davies AM +7 more
europepmc +2 more sources
Frontiers in Immunology, 2022 BackgroundThere is limited information on the functional neutralizing capabilities of breastmilk SARS-CoV-2-specific antibodies and the potential adulteration of breastmilk with vaccine mRNA after SARS-CoV-2 mRNA vaccination.MethodsWe conducted a ...
Kee Thai Yeo +23 more
doaj +1 more source
Isotype selection for antibody-based cancer therapy [PDF]
Clinical and Experimental Immunology, 2020 The clinical application of monoclonal antibodies (mAbs) revolutionised the field of cancer therapy as it enabled the successful treatment of previously untreatable types of cancer. Different mechanisms play a role in the anti-tumour effect of mAbs and both target engagement with the Fab arm as well as Fc-mediated effector functions contribute to the ...
N Vukovic +3 more
openaire +3 more sources
Determining antibody-binding site of streptococcal pyrogenic exotoxin B to protect mice from group a streptococcus infection. [PDF]
PLoS ONE, 2013 Streptococcal pyrogenic exotoxin B (SPE B), a cysteine protease, is an important virulence factor in group A streptococcal (GAS) infection. SPE B binds and cleaves antibody isotypes and further impairs the immune system by inhibiting complement ...
Nina Tsao +5 more
doaj +1 more source
Development of a Macrophage-Based ADCC Assay
Vaccines, 2021 Fc-dependent effector functions are an important determinant of the in vivo potency of therapeutic antibodies. Effector function is determined by the combination of FcRs bound by the antibody and the cell expressing the relevant FcRs, leading to antibody-
Melissa B. Uccellini +4 more
doaj +1 more source
Anticentromere Antibody Levels and Isotypes and the Development of Systemic Sclerosis [PDF]
Arthritis & Rheumatology, 2021 ObjectiveLittle is known on the disease course of very early systemic sclerosis (SSc). Among the information yet to be elucidated is whether anticentromere antibody (ACA) isotype levels can serve as biomarkers for future SSc development and for organ involvement.
van Leeuwen, Nina M +14 more
openaire +4 more sources
Antiviral Activities of HIV-1-Specific Human Broadly Neutralizing Antibodies Are Isotype-Dependent
Vaccines, 2022 Broadly neutralizing antibodies (bNAbs) offer promising opportunities for preventing HIV-1 infection. The protection mechanisms of bNAbs involve the Fc domain, as well as their Fab counterpart.
Blandine Noailly +7 more
doaj +1 more source
Diagnostic performance of antibody isotypes against S. pneumoniae cell wall antigens.
, 2021 Diagnostic performance of antibody isotypes against S. pneumoniae cell wall antigens.
Ann R. Falsey (10199544) +12 more
core +1 more source