Results 71 to 80 of about 736,142 (286)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Discovery of novel, potent and orally available benzoazipinone derivatives that elicit MKLP2-inhibitory phenotypes

European Journal of Medicinal Chemistry Reports
Mitotic kinesin-like protein 2 (MKLP2/KIF20A) is a key mitotic regulator frequently overexpressed in human malignancies and its abundance is positively correlated with poor outcomes of the disease.
Jian Huang, Ting Zhang, Julia Kalashova, Jinhua Li, Chenglu Yang, Linsheng Zhong, Xiaohu Zhou, Qiong Shi, Gang Lv, Jiadai Chenyu, Yidan Xia Abuliezi, Duo Yu, Xuejiao Jiang, Mallu Chenna Reddy, Namrta Choudhry, Naganna Nimishetti, Dun Yang   +16 more
doaj   +1 more source

TLR4-dependent effects of ISAg treatment on conventional T cell polarization in vivo

Animal Cells and Systems, 2019
We recently demonstrated that the polysaccharide component of the Korean medicinal herb Angelica gigas (immuno-stimulatory fraction of A. gigas; ISAg) induces anticancer effects in mice by activating natural killer (NK) and natural killer T (NKT) cells ...
Sung Won Lee, Hyun Jung Park, Seo Hyun Kim, Sooyong Shin, Kyung Hee Kim, Sang Jae Park, Seokmann Hong, Sung Ho Jeon   +7 more
doaj   +1 more source

Frontiers of MicroRNA Signature in Non-small Cell Lung Cancer

Frontiers in Cell and Developmental Biology, 2021
Lung cancer is the leading cause of cancer-related deaths worldwide and non-small cell lung cancer (NSCLC) accounts for more than 80% of all lung cancer cases.
Xinping Zhu, Masahisa Kudo, Xiangjie Huang, Hehuan Sui, Haishan Tian, Carlo M. Croce, Ri Cui, Ri Cui   +7 more
doaj   +1 more source

Redox control of multidrug resistance and Its possible modulation by antioxidants [PDF]

, 2016
Clinical efficacy of anticancer chemotherapies is dramatically hampered by multidrug resistance (MDR) dependent on inherited traits, acquired defence against toxins, and adaptive mechanisms mounting in tumours.
Cort, A., De Luca, C., Korkina, L., Ozben, T., Saso, Luciano   +4 more
core   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Relevance of Fusion Genes in Pediatric Cancers: Toward Precision Medicine

Molecular Therapy: Nucleic Acids, 2017
Pediatric cancers differ from adult tumors, especially by their very low mutational rate. Therefore, their etiology could be explained in part by other oncogenic mechanisms such as chromosomal rearrangements, supporting the possible implication of fusion
Célia Dupain, Anne Catherine Harttrampf, Giorgia Urbinati, Birgit Geoerger, Liliane Massaad-Massade   +4 more
doaj   +1 more source

Unusual DNA binding modes for metal anticancer complexes [PDF]

, 2009
DNA is believed to be the primary target for many metal-based drugs. For example, platinum-based anticancer drugs can form specific lesions on DNA that induce apoptosis.
Pizarro, Ana M., Sadler, P. J.
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Management of malignant inferior vena cava syndrome (IVCS) by endovascular bridging stent placement

Radiology Case Reports
A 73-year-old male patient was admitted to the emergency department with dyspnea and severe edema in the lower extremities. The patient had been diagnosed with extensive small-cell lung cancer 15 months previously.
Manos Siderakis, MD, BSc, MSc, Georgia Papavasileiou, MD, MSc, Margarita Moutou, MD, MSc, George Gkeneralis, MD, MSc, PhD, Viktoria Kartsouni, MD, MSc, PhD, Myrsini Gkeli, MD, MSc   +5 more
doaj   +1 more source