Results 11 to 20 of about 6,300,141 (198)

Novel Substituted Azoloazines with Anticoagulant Activity [PDF]

International Journal of Molecular Sciences, 2023
Hypercytokinemia, or cytokine storm, often complicates the treatment of viral and bacterial infections, including COVID-19, leading to the risk of thrombosis. However, the use of currently available direct anticoagulants for the treatment of COVID-19 patients is limited due to safety reasons.
Alexander A. Spasov, Olga V. Fedorova, Nikolay A. Rasputin, Irina G. Ovchinnikova, Rashida I. Ishmetova, Nina K. Ignatenko, Evgeny B. Gorbunov, Gusein A. o. Sadykhov, Aida F. Kucheryavenko, Kseniia A. Gaidukova, Victor S. Sirotenko, Gennady L. Rusinov, Egor V. Verbitskiy, Valery N. Charushin   +13 more
core   +5 more sources

Does plasmin have anticoagulant activity?

Vascular Health and Risk Management, 2010
Jane Hoover-PlowJoseph J Jacobs Center for Thrombosis and Vascular Biology, Departments of Cardiovascular Medicine and Molecular Cardiology, Lerner Research Institute Cleveland Clinic, Ohio, USAAbstract: The coagulation and fibrinolytic pathways regulate
Jane Hoover-Plow
doaj   +1 more source

Extraction, purification, characterization, and in vitro anticoagulant activity of polysaccharides from Cordyceps militaris [PDF]

Frontiers in Nutrition
ObjectiveTo elucidate the anticoagulant effects of Cordyceps militaris polysaccharides and provide a scientific basis for their application in functional foods and biomedicine.MethodsCrude polysaccharide (CC-1) was extracted by water extraction and ...
Cai-fang Li, Li-gan Lu, Jun-shang Liu, Cheng-qi Liu, Yan Ma, Shuang-shuang Zhang, Zi-heng Jin, Chang-yang Ma, Chang-yang Ma, Jin-mei Wang, Jin-mei Wang   +10 more
doaj   +2 more sources

Purification of an Acidic Polysaccharide with Anticoagulant Activity from the Marine Sponge Sarcotragus spinosulus [PDF]

Marine Drugs
Thromboembolic conditions are the most common cause of death in developed countries. Anticoagulant therapy is the treatment of choice, and heparinoids and warfarin are the most adopted drugs. Sulphated polysaccharides extracted from marine organisms have
Gabriele Nieddu, Gabriele Obino, Cristina Ciampelli, Antonio Brunetti, Tiziana Cubeddu, Renata Manconi, Giacinta Angela Stocchino, Giovanni Andrea Deiana, Marilena Formato, Antonio Junior Lepedda   +9 more
doaj   +2 more sources

Preparation of Low-Molecular-Weight Fucoidan with Anticoagulant Activity by Photocatalytic Degradation Method [PDF]

Foods, 2022
It is a challenge to degrade sulfated polysaccharides without stripping sulfate groups. In the present study, a photocatalytic method was applied to degrade fucoidan, a sulfated polysaccharide from brown algae.
Yihui Qi, Lilong Wang, Ying You, Xiaona Sun, Chengrong Wen, Yinghuan Fu, Shuang Song   +6 more
doaj   +2 more sources

Azolo[1,5-a]pyrimidines and Their Condensed Analogs with Anticoagulant Activity [PDF]

Molecules, 2022
Hypercytokinemia, or cytokine storm, is one of the severe complications of viral and bacterial infections, involving the release of abnormal amounts of cytokines, resulting in a massive inflammatory response.
Vladimir L. Rusinov, Alexandr A. Spasov, Svetlana K. Kotovskaya, Victor V. Fedotov, Victor S. Sirotenko, Georgiy M. Uskov, Aida F. Kucheryavenko, Pavel M. Vasiliev, Kseniya A. Gaidukova, Vadim A. Kosolapov, Konstantin V. Savateev   +10 more
core   +2 more sources

Bioactive Glycosaminoglycans from Caranx crysos: A Structure–Function Study of Selective Anticoagulant Activity [PDF]

Marine Drugs
Glycosaminoglycans (GAGs) are the carbohydrate portion of proteoglycans (PGS), a family of complex biomacromolecules ubiquitously found in the extracellular matrix and on cell surfaces that play critical roles in a plethora of physiological and ...
Ranim Kroumi, Soumaya Alimi, Fabiana Esposito, Asma Haffouz, Basma Hadjkacem, Angela Casillo, Anissa Haddar, Assaad Sila, Emiliano Bedini, Ali Bougatef   +9 more
doaj   +2 more sources

Structural Characterization and Anticoagulant Activity of a 3-O-Methylated Heteroglycan From Fruiting Bodies of Pleurotus placentodes [PDF]

Frontiers in Chemistry, 2022
Pleurotus placentodes, a fungus, belongs to the Pleurotaceae family. The aim of the present study was to characterize the structure of a novel polysaccharide from fruiting bodies of P. placentodes (PPp-W) and evaluate its anticoagulant activity in vitro.
Zhen-Hua Yin, Xiao-Peng Liu, Jin-Mei Wang, Xue-Feng Xi, Xue-Feng Xi, Yan Zhang, Rui-Lin Zhao, Wen-Yi Kang   +7 more
doaj   +2 more sources

Controlling the sulfation density of glycosaminoglycan glycopolymer mimetics enables high antiviral activity against SARS-CoV-2 and reduces anticoagulant activity [PDF]

Biomacromolecules
Sulfated glycosaminoglycans (sGAGs) make up a class of cell-surface glycans known to mediate pathogen engagement. Glycopolymers mimicking sGAGs can reduce or prevent pathogen attachment.
Snyder, Nicole L., Hartmann, Laura, Hermsen, Derik, Bonda, Lorand, Hoffmann, Miriam, Fels, Ines, Schelhaas, Mario, Ludwig, Stephan, Anhlan, Darisuran, Hrincius, Eike R.   +9 more
core   +2 more sources

Anticoagulant Activity in Medicinal Plants: A Systematic and Bibliometric Review Over 10 Years (2011-2021) [PDF]

, 2023
Anticoagulants are helpful as treatment for coagulation disorders. Medicinal plants have been demonstrated to be part of history as a traditional treatment for this disorder, and these plants have anticoagulant properties.
Amal A.M. Elgharbawy, Kamaru Azman, Auni Nur Sabrina, Elgharbawy, Amal A.M., Auni Nur Sabrina Kamaru Azman   +3 more
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