Results 11 to 20 of about 156,819 (199)

Cystamine preparations exhibit anticoagulant activity.

PLoS ONE, 2015
Transglutaminases are a superfamily of isoenzymes found in cells and plasma. These enzymes catalyze the formation of ε-N-(γ-glutamyl)-lysyl crosslinks between proteins.
Maria M Aleman, Lori A Holle, Katherine G Stember, Christa I Devette, Dougald M Monroe, Alisa S Wolberg   +5 more
doaj   +4 more sources

Novel Substituted Azoloazines with Anticoagulant Activity. [PDF]

Int J Mol Sci, 2023
Hypercytokinemia, or cytokine storm, often complicates the treatment of viral and bacterial infections, including COVID-19, leading to the risk of thrombosis. However, the use of currently available direct anticoagulants for the treatment of COVID-19 patients is limited due to safety reasons.
Spasov AA, Fedorova OV, Rasputin NA, Ovchinnikova IG, Ishmetova RI, Ignatenko NK, Gorbunov EB, Sadykhov GAO, Kucheryavenko AF, Gaidukova KA, Sirotenko VS, Rusinov GL, Verbitskiy EV, Charushin VN.   +13 more
europepmc   +4 more sources

Preparation, Anticoagulant and Antioxidant Properties of Glucosamine-Heparin Salt

Marine Drugs, 2022
Excessive inorganic ions in vivo may lead to electrolyte disorders and induce damage to the human body. Therefore, preparation of enhanced bioactivity compounds, composed of activated organic cations and organic anions, is of great interest among ...
Qin Miao, Qing Li, Wenqiang Tan, Yingqi Mi, Bing Ma, Jingjing Zhang, Zhanyong Guo   +6 more
doaj   +1 more source

Synthetic polymers with anticoagulant activity [PDF]

, 1979
Polymers with C=C bonds have been modified by reaction with chlorosulfonyl isocyanate (CSI). Addition products were obtained in yields varying from 60% to 75%.
Bantjes, A., Beugeling, T., Does, L. van der, Froehling, P.E.   +3 more
core   +2 more sources

The anticoagulant activation of antithrombin by heparin [PDF]

Proceedings of the National Academy of Sciences, 1997
Antithrombin, a plasma serpin, is relatively inactive as an inhibitor of the coagulation proteases until it binds to the heparan side chains that line the microvasculature. The binding specifically occurs to a core pentasaccharide present both in the heparans and in their therapeutic derivative heparin.
Jin, Lei, Abrahams, Jan Pieter, Skinner, Richard, Petitou, Maurice, Pike, Robert N., Carrell, Robin W.   +5 more
openaire   +3 more sources

Design of a new type of coating for the controlled release of heparin [PDF]

, 1997
Thrombus formation at the surface of blood contacting devices can be prevented by local release of heparin. Preferably, the release rate should be constant for prolonged periods of time.
Engbers, G.H.M., Feijen, J., Hinrichs, W.L.J., Hoopen, H.W.M. ten, Wissink, M.J.B.   +4 more
core   +3 more sources

The anticoagulant activity of carrageenan

Journal of Pharmacy and Pharmacology, 1965
Abstract λ-Carrageenans and κ-carrageenans from samples of Chondrus crispus, carrageenan from Polyides rotundus and degraded carrageenan from Eucheuma spinosum have anticoagulant activity on intravenous injection in the rabbit. Anticoagulant activity appears to be caused by a general reaction with plasma protein.
W Anderson, J G C Duncan, J E Harthill
openaire   +2 more sources

Sulfated Derivatives of Arabinogalactan and Their Anticoagulant Activity [PDF]

Russian Journal of Bioorganic Chemistry, 2019
The IR spectra and molecular mass distribution of arabinogalactan sulfates in the form of sodium and ammonium salts, obtained using various sulfating reagents, were compared. According to the obtained data, the sulfated derivatives of arabinogalactan differ from each other by the nature of the hydrogen bonds and the molecular weight distribution ...
Svetlana Alekseyevna Kuznetsova, Natal'ya Yur'yevna Vasilyeva, Natal'ya Nikolayevna Drozd, Mikhail Aleksandrovich Mikhailenko, Tat'yana Petrovna Shakhtshneider, Yuriy Nikolayevich Malyar, Boris Nikolayevich Kuznetsov, Nikolay Vasil'yevich Chesnokov   +7 more
openaire   +5 more sources

Discovery and development of Factor Xa inhibitors (2015–2022)

Frontiers in Pharmacology, 2023
As a pathological coagulation process, thrombus can lead to many serious diseases, including ischemic stroke, acute myocardial infarction (AMI), acute coronary syndrome (ACS), and deep venous thrombosis (DVT).
Wei Zheng, Wei Zheng, Xiaoqin Dai, Binyao Xu, Wei Tian, Jianyou Shi   +5 more
doaj   +1 more source

New Hybrid Tetrahydropyrrolo[3,2,1-ij]quinolin-1-ylidene-2-thioxothiazolidin-4-ones as New Inhibitors of Factor Xa and Factor XIa: Design, Synthesis, and In Silico and Experimental Evaluation

Molecules, 2023
Despite extensive research in the field of thrombotic diseases, the prevention of blood clots remains an important area of study. Therefore, the development of new anticoagulant drugs with better therapeutic profiles and fewer side effects to combat ...
Nadezhda P. Novichikhina, Alexander S. Shestakov, Svetlana M. Medvedeva, Anna M. Lagutina, Mikhail Yu. Krysin, Nadezhda A. Podoplelova, Mikhail A. Panteleev, Ivan S. Ilin, Alexey V. Sulimov, Anna S. Tashchilova, Vladimir B. Sulimov, Athina Geronikaki, Khidmet S. Shikhaliev   +12 more
doaj   +1 more source