Results 21 to 30 of about 6,300,141 (198)

The anticoagulant activation of antithrombin by heparin [PDF]

Proceedings of the National Academy of Sciences, 1997
Antithrombin, a plasma serpin, is relatively inactive as an inhibitor of the coagulation proteases until it binds to the heparan side chains that line the microvasculature. The binding specifically occurs to a core pentasaccharide present both in the heparans and in their therapeutic derivative heparin.
Jin, Lei, Abrahams, Jan Pieter, Skinner, Richard, Petitou, Maurice, Pike, Robert N., Carrell, Robin W.   +5 more
openaire   +3 more sources

Sulfated Derivatives of Arabinogalactan and Their Anticoagulant Activity [PDF]

Russian Journal of Bioorganic Chemistry, 2019
The IR spectra and molecular mass distribution of arabinogalactan sulfates in the form of sodium and ammonium salts, obtained using various sulfating reagents, were compared. According to the obtained data, the sulfated derivatives of arabinogalactan differ from each other by the nature of the hydrogen bonds and the molecular weight distribution ...
Svetlana Alekseyevna Kuznetsova, Natal'ya Yur'yevna Vasilyeva, Natal'ya Nikolayevna Drozd, Mikhail Aleksandrovich Mikhailenko, Tat'yana Petrovna Shakhtshneider, Yuriy Nikolayevich Malyar, Boris Nikolayevich Kuznetsov, Nikolay Vasil'yevich Chesnokov   +7 more
openaire   +5 more sources

Synthesis of new coumarin derivatives with suspected anticoagulant activity [PDF]

المجلة العراقية للصيدلة, 2012
Objectives: To synthesize three series of new coumarin derivatives and to screen their anticoagulant activity in rabbits in order to define in more exact terms the structural features that responsible for the anticoagulant activity of coumarins. Methods:
Yasser Fakri Mustafa
doaj   +1 more source

Heparin mimetics with anticoagulant activity

Medicinal Research Reviews, 2018
AbstractHeparin, a sulfated polysaccharide belonging to the glycosaminoglycan family, has been widely used as an anticoagulant drug for decades and remains the most commonly used parenteral anticoagulant in adults and children. However, heparin has important clinical limitations and is derived from animal sources which pose significant safety and ...
Abdullah Al Nahain, Vera Ignjatovic, Paul Monagle, John Tsanaktsidis, Vito Ferro   +4 more
openaire   +6 more sources

Discovery and development of Factor Xa inhibitors (2015–2022)

Frontiers in Pharmacology, 2023
As a pathological coagulation process, thrombus can lead to many serious diseases, including ischemic stroke, acute myocardial infarction (AMI), acute coronary syndrome (ACS), and deep venous thrombosis (DVT).
Wei Zheng, Wei Zheng, Xiaoqin Dai, Binyao Xu, Wei Tian, Jianyou Shi   +5 more
doaj   +1 more source

Pharmacology complex compound of pro-gly-pro-leu with heparin: hypoglycemic, fibrinolitic and anticoagulant effects in rats with hyperglycemia

Фармация и фармакология (Пятигорск), 2019
Previously it was shown that the use of regulatory peptides of the glyprolin family helps to normalize the hemostasis system and blood glucose levels in experimental resistant hyperglycemia in rats, similar to type 2 diabetes mellitus in humans.
T. Yu. Obergan, N. F. Myasoedov, M. E. Grigorjeva, L. A. Lyapina, T. A. Shubina, L. A. Andreeva   +5 more
doaj   +1 more source

New Hybrid Tetrahydropyrrolo[3,2,1-ij]quinolin-1-ylidene-2-thioxothiazolidin-4-ones as New Inhibitors of Factor Xa and Factor XIa: Design, Synthesis, and In Silico and Experimental Evaluation

Molecules, 2023
Despite extensive research in the field of thrombotic diseases, the prevention of blood clots remains an important area of study. Therefore, the development of new anticoagulant drugs with better therapeutic profiles and fewer side effects to combat ...
Nadezhda P. Novichikhina, Alexander S. Shestakov, Svetlana M. Medvedeva, Anna M. Lagutina, Mikhail Yu. Krysin, Nadezhda A. Podoplelova, Mikhail A. Panteleev, Ivan S. Ilin, Alexey V. Sulimov, Anna S. Tashchilova, Vladimir B. Sulimov, Athina Geronikaki, Khidmet S. Shikhaliev   +12 more
doaj   +1 more source

Anticoagulation for atrial fibrillation in active cancer (Review)

Oncology Letters, 2022
Atrial fibrillation (AF) may often pre-exist in patients with newly diagnosed cancer or occur with increased frequency shortly after cancer diagnosis. Patients with active cancer and AF have a particularly high risk of thromboembolic complications, as both conditions carry a risk of thrombosis.
Farmakis, Dimitrios, Papakotoulas, Pavlos, Angelopoulou, Eleni, Bischiniotis, Theodoros, Giannakoulas, George, Kliridis, Panagiotis, Richter, Dimitrios, Paraskevaidis, Ioannis   +7 more
openaire   +3 more sources

Synthetic polymers with anticoagulant activity [PDF]

, 1979
Polymers with C=C bonds have been modified by reaction with chlorosulfonyl isocyanate (CSI). Addition products were obtained in yields varying from 60% to 75%.
Bantjes, A., Beugeling, T., Froehling, P.E., van der Does, L., L. Van Der Does, T. Beugeling, A. Bantjes, P. E. Froehling   +7 more
core   +1 more source

Large-scale structure of brown rat (Rattus norvegicus) populations in England: effects on rodenticide resistance [PDF]

, 2015
The brown rat (Rattus norvegicus) is a relatively recent (
Eleanor P. Jones, Mohd Z.H. Haniza, R. H. Smith (7659080), Jones, Eleanor P., Adams, Sally, Sally Adams, MacNicoll, Alan, Mark S. Lambert, Eamonn B. Mallon, S. Adams (1469704), Mallon, Eamonn B., M. S. Lambert (7659083), Haniza, Mohd Z.H., Alan MacNicoll, Eamonn Bernard Mallon (7607027), Smith, Robert H., Robert H. Smith, E. P. Jones (7659074), M. Z. Haniza (7659071), A. M. MacNicoll (7659077), Lambert, Mark S.   +20 more
core   +2 more sources