Results 71 to 80 of about 75,534 (305)

Optimal management of seizures associated with tuberous sclerosis complex: current and emerging options. [PDF]

, 2014
Seizures are clinically significant manifestations associated with 79%-90% of patients with tuberous sclerosis complex. Often occurring within the first year of life in the form of infantile spasms, seizures interfere with neuropsychiatric, social, and ...
Fallah, Aria, Wang, Shelly
core   +2 more sources

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, EarlyView.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

Development of learning objectives for neurology in a veterinary curriculum: Part II: Postgraduates [PDF]

, 2015
Background: Specialization in veterinary medicine in Europe is organized through the Colleges of the European Board of Veterinary Specialization. To inform updating of the curriculum for residents of the European College of Veterinary Neurology (ECVN ...
Anderson, T J, Añor, S, Barcelona, CEU Cardinal Herrera University, Ehlers, J P, Glasgow, Hannover School Vet Med, Lin, Y W, Lujan-Feliu-Pascual, A, Penderis, J, Stein, V M, Tipold, A, University Witten-Herdecke, Volk, H A   +13 more
core   +6 more sources

Voclosporin‐induced gingival enlargement: A case report

Clinical Advances in Periodontics, EarlyView.
Abstract Background Drug‐influenced gingival enlargement (DIGE) is a recognized adverse effect of certain medications, particularly immunosuppressants like cyclosporin and tacrolimus. However, there have been no documented cases of DIGE associated with voclosporin, a newer calcineurin inhibitor used primarily to treat lupus nephritis.
Francesca Racca, Jessica M. Greco, Dimitris N. Tatakis   +2 more
wiley   +1 more source

Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome. [PDF]

, 2019
Dravet syndrome is a life-threatening early-onset epilepsy not well controlled by antiepileptic drugs. Drugs that modulate serotonin (5-HT) signalling, including clemizole, locaserin, trazodone and fenfluramine, have recently emerged as potential ...
Baraban, Scott C, Grandjean, Jean-Marc, Griffin, Aliesha L, Jaishankar, Priyadarshini, Olson, Steven H, Renslo, Adam R   +5 more
core   +1 more source

A Phase 1, Randomized, Placebo‐Controlled, Multiple‐Dose, Double‐Blind Study to Evaluate and Compare the Pharmacokinetics and Safety of Rimegepant in Healthy Adult Japanese and Caucasian Individuals

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This Phase 1, randomized, placebo‐controlled, double‐blind study assessed the pharmacokinetic profile of rimegepant (25, 75, or 150 mg once daily for 14 days) in healthy Japanese and Caucasian adults. Exposures were modestly increased in Japanese participants compared with Caucasian participants following a single dose of rimegepant (Day 1 ...
Rajinder Bhardwaj, Chay Ngee Lim, Yinhua Li, Kyle T. Matschke, Richard Bertz, Robert Croop, Jing Liu   +6 more
wiley   +1 more source

New anti-epileptic drugs in paediatrics

Anales de Pediatría (English Edition), 2019
It is estimated that about 70 million people all over the world suffer from epilepsy, half of which are children, in whom the prevalence is around 0.5–0.8%.
Ignacio Málaga, Rocío Sánchez-Carpintero, Susana Roldán, Julio Ramos-Lizana, Juan José García-Peñas   +4 more
doaj   +1 more source

Polygonogram and isobolographic analysis of interactions between various novel antiepileptic drugs in the 6-Hz corneal stimulation-induced seizure model in mice.

PLoS ONE, 2020
Pharmacotherapy with two antiepileptic drugs in combination is usually prescribed to epilepsy patients with refractory seizures. The choice of antiepileptic drugs in combination should be based on synergistic cooperation of the drugs with respect to ...
Jarogniew J Luszczki, Anna Panasiuk, Mirosław Zagaja, Sławomir Karwan, Hubert Bojar, Zbigniew Plewa, Magdalena Florek-Łuszczki   +6 more
doaj   +1 more source

Evaluation of perampanel as monotherapy for focal seizures: Experience from open-label extension studies [PDF]

, 2017
Perampanel, a selective, non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist, is approved for adjunctive treatment of focal seizures, with or without secondarily generalized seizures, and for primary ...
Cartwright, Karen, Formerly: Eisai Ltd., Kwan, Patrick, Laurenza, Antonio, Mintzer, Scott, Patten, Anna   +5 more
core   +1 more source

Volumetric MRI study of the brain in patients with neurocysticercosis and mesial temporal lobe epilepsy

Epileptic Disorders, EarlyView.
Abstract Objective Neurocysticercosis (NCC) is a common parasitic infection of the central nervous system and a known cause of focal epilepsy. Its potential role in triggering or contributing to mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE‐HS) is suggested, but the impact on brain volumetry remains unclear.
Jaisa Quedi Araújo, Bruna da Silveira Arruda, Sandra Polita, Maurício Anés, Thiago Junqueira Ribeiro de Rezende, Matheus de Lima Ruffini, Adolfo Moraes de Souza, Jordana Soares Chaves, Fabiano Reis, Marino Muxfeldt Bianchin, Juliana Ávila Duarte   +10 more
wiley   +1 more source