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Sources of Antifungal Drugs [PDF]
Journal of Fungi, 2023 Due to their eukaryotic heritage, the differences between a fungal pathogen’s molecular makeup and its human host are small. Therefore, the discovery and subsequent development of novel antifungal drugs are extremely challenging.
Giel Vanreppelen +3 more
doaj +6 more sources
Metabolites, 2020 We reviewed the licensed antifungal drugs and summarized their mechanisms of action, pharmacological profiles, and susceptibility to specific fungi. Approved antimycotics inhibit 1,3-β-d-glucan synthase, lanosterol 14-α-demethylase, protein ...
Jiří Houšť +2 more
doaj +5 more sources
Frontiers in Pharmacology, 2022 Aims: We aimed to estimate the risk of drug-induced liver injury (DILI) from various antifungal treatments with azoles and echinocandins causing in real-world practice.Methods: We performed disproportionality and Bayesian analyses based on data from the ...
Zhi-Xuan Zhou +13 more
doaj +2 more sources
Applied and Environmental Soil Science, 2021 The occurrence of residual antifungal agents through indiscriminate prophylactic use and inappropriate disposal has been reported in wastewater treatment plants (WWTPs), surface water, and groundwater environments. Opportunistic pathogenic aquatic yeasts
Mzimkhulu E. Monapathi +6 more
doaj +2 more sources
Repurposing antifungal drugs for cancer therapy [PDF]
Journal of Advanced Research, 2023 Background: Repurposing antifungal drugs in cancer therapy has attracted unprecedented attention in both preclinical and clinical research due to specific advantages, such as safety, high-cost effectiveness and time savings compared with cancer drug ...
Ningna Weng +5 more
doaj +2 more sources
Antifungal Activity of Select Essential Oils against Candida auris and Their Interactions with Antifungal Drugs. [PDF]
Pathogens, 2022 Candida auris is an emerging fungal pathogen that commonly causes nosocomial blood infections in the immunocompromised. Several factors make this pathogen a global threat, including its misidentification as closely related species, its ability to survive
Parker RA +4 more
europepmc +2 more sources
Repurposing non-antifungal drugs auranofin and pentamidine in combination as fungistatic antifungal agents against C. albicans [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Fungal infection is a serious global health issue, causing approximately 1.5 million mortalities annually. However, clinically available anti-fungal drugs are limited, especially for multidrug-resistant fungal infections.
Jiaying Lin +7 more
doaj +2 more sources
Synergistic antifungal effects and mechanisms of amantadine hydrochloride combined with azole antifungal drugs on drug-resistant Candida albicans [PDF]
Frontiers in Cellular and Infection MicrobiologyIntroductionThe increasing resistance of Candida albicans (C. albicans) to conventional antifungal drugs poses a great challenge to the clinical treatment of infections caused by this yeast.
Xiuyun Li +5 more
doaj +2 more sources
Chemometric Methods—A Valuable Tool for Investigating the Interactions Between Antifungal Drugs (Including Antifungal Antibiotics) and Food [PDF]
AntibioticsBackground/Objectives: Developing antifungal drugs with lower potential for interactions with food may help to optimize treatment and reduce the risk of antimicrobial resistance.
Agnieszka Wiesner-Kiełczewska +3 more
doaj +2 more sources
An Aptamer-Based Biosensor for the Azole Class of Antifungal Drugs [PDF]
mSphere, 2017 This technical report describes the development of an aptamer for sensing azole antifungal drugs during therapeutic drug monitoring. Modified synthetic evolution of ligands through exponential enrichment (SELEX) was used to discover a DNA aptamer ...
Gregory R. Wiedman +6 more
doaj +2 more sources