Results 21 to 30 of about 85,603 (246)

Evaluation of Antifungal Selective Toxicity Using Candida glabrata ERG25 and Human SC4MOL Knock-In Strains

Journal of Fungi, 2023
With only four classes of antifungal drugs available for the treatment of invasive systemic fungal infections, the number of resistant fungi is increasing, highlighting the urgent need for novel antifungal drugs.
Keiko Nakano, Michiyo Okamoto, Azusa Takahashi-Nakaguchi, Kaname Sasamoto, Masashi Yamaguchi, Hiroji Chibana   +5 more
doaj   +1 more source

Drug-Drug Interaction of Antifungal Drugs

YAKUGAKU ZASSHI, 2005
This article reviews the in vitro metabolic and the in vivo pharmacokinetic drug-drug interactions with antifungal drugs, including fluconazole, itraconazole, micafungin, miconazole, and voriconazole. In the in vitro interaction studies, the effects of antifungal drugs on specific activities of cytochrome P450s (CYPs), including CYP1A2, CYP2C9, CYP2C19,
Toshiro, Niwa, Toshifumi, Shiraga, Akira, Takagi   +2 more
openaire   +3 more sources

Medicines for Malaria Venture COVID Box: a source for repurposing drugs with antifungal activity against human pathogenic fungi

Memorias do Instituto Oswaldo Cruz, 2021
BACKGROUND Treatment of mycoses is often ineffective, usually prolonged, and has some side effects. These facts highlight the importance of discovering new molecules to treat fungal infections.
Rodrigo Almeida-Paes, Iara Bastos de Andrade, Mariana Lucy Mesquita Ramos, Marcus Vinícius de Araújo Rodrigues, Vinícius Alves do Nascimento, Andréa Reis Bernardes-Engemann, Susana Frases   +6 more
doaj   +1 more source

Novel Antifungal Compounds Discovered in Medicines for Malaria Venture’s Malaria Box

mSphere, 2018
Similarities in fungal and animal cells make antifungal discovery efforts more difficult than those for other classes of antimicrobial drugs. Currently, there are only three major classes of antifungal drugs used for the treatment of systemic fungal ...
Eric H. Jung, David J. Meyers, Jürgen Bosch, Arturo Casadevall   +3 more
doaj   +1 more source

Missed Opportunities for Antifungal Stewardship during the COVID-19 Era

Antibiotics, 2023
Significant increases in antibacterial use were observed during the COVID-19 pandemic. However, subsequent analyses found this increase in antibiotic use to be excessive in comparison with the relatively low rates of bacterial coinfection.
Brandon K. Hawkins, Samantha D. Walker, Mahmoud A. Shorman   +2 more
doaj   +1 more source

High Efficiency Drug Repurposing Design for New Antifungal Agents

Methods and Protocols, 2019
Current antifungal interventions have often limited efficiency in treating fungal pathogens, particularly those resistant to commercial drugs or fungicides.
Jong H. Kim, Kathleen L. Chan, Luisa W. Cheng, Lisa A. Tell, Barbara A. Byrne, Kristin Clothier, Kirkwood M. Land   +6 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

An insight into new strategies and targets to combat antifungal resistance: A comprehensive review

European Journal of Medicinal Chemistry Reports
Antifungal drugs target specific components or processes within fungal cells to prevent or eliminate their growth. Various antifungal targets exist, including the cell membrane disrupted by drugs such as azoles and polyenes.
Deepali Nahar, Popat Mohite, Ankita Lonkar, Vijay R. Chidrawar, Rajesh Dodiya, Md Jamir Uddin, Sudarshan Singh, Bhupendra G. Prajapati   +7 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source