Results 51 to 60 of about 63,671 (266)

Tolerability and safety of antifungal drugs

Reviews in Health Care, 2013
When treating critically ill patients, as those with fungal infections, attention should be focused on the appropriate use of drugs, especially in terms of dose, safety, and tolerability. The fungal infection itself and the concomitant physiological disorders concur to increase the risk of mortality in these patients, therefore the use of any ...
openaire   +4 more sources

851. Metabolic Changes Contributing to Age-Associated Antifungal Tolerance in Cryptococcus neoformans

Open Forum Infectious Diseases, 2023
Abstract Background Cryptococcus neoformans (CN) is a facultative intracellular pathogen that divides asymmetrically, resulting in different phenotypes of the mother and daughter cells. After 8-10 divisions, mother cells become more resistant to phagocytic killing by macrophages and resistant to ...
Yoo, Kyungyoon, de Oliveira, Natalia Kronbauer, Bhattacharya, Somanon, Fries, Bettina F   +3 more
openaire   +1 more source

Bacterial-derived exopolysaccharides enhance antifungal drug tolerance in a cross-kingdom oral biofilm [PDF]

The ISME Journal, 2018
Abstract Fungal–bacterial interactions generate unique biofilms that cause many infections in humans. Candida albicans interact with Streptococcus mutans in dental biofilms associated with severe childhood tooth-decay, a prevalent pediatric oral disease.
Dongyeop Kim, Yuan Liu, Raphael I Benhamou, Hiram Sanchez, Áurea Simón-Soro, Yong Li, Geelsu Hwang, Micha Fridman, David R Andes, Hyun Koo   +9 more
openaire   +2 more sources

Comprehensive Genome Analysis on the Novel Species Sphingomonas panacis DCY99(T) Reveals Insights into Iron Tolerance of Ginseng [PDF]

, 2020
Plant growth-promoting rhizobacteria play vital roles not only in plant growth, but also in reducing biotic/abiotic stress. Sphingomonas panacis DCY99(T) is isolated from soil and root of Panax ginseng with rusty root disease, characterized by raised ...
Balusamy, Sri Renukadevi, Huo, Yue, Kim, Donghyuk, Kim, Yeon-Ju, Le, Hoa Thi, Nong, Linh Khanh, Park, Joon Young, Yang, Deok Chun   +7 more
core   +1 more source

Interactions of Bacillus Mojavensis and Fusarium Verticillioides With a Benzoxazolinone (Boa) and Its Transformation Product, Apo [PDF]

, 2007
En:Journal of Chemical Ecology (2007, vol. 33, n. 10, p. 1885-1897)The benzoxazolinones, specifically benzoxazolin-2(3H)-one (BOA), are important transformation products of the benzoxazinones that can serve as allelochemicals providing resistance to ...
A. Baumeler, A. E. Glenn, A. E. Glenn, A. E. Glenn, A. Friebe, A. Friebe, A. Givovich, A. I. Virtanen, A. S. Atwal, Anthony E. Glenn, C. W. Bacon, C. W. Bacon, C. W. Bacon, C. W. Bacon, C. W. Bacon, Charles W. Bacon, David Marin, Dorothy M. Hinton, E. Wang, F. A. Macias, Francisco A. Macías, G. Nair, H. Hartenstein, H. M. Niemeyer, I. S. Fomsgaard, I. S. Fomsgaard, J. A. Klun, J. G. Waes, J. I. Fritz, K. A. Voss, K. Anzai, K. Pratt, L. J. Corcuera, L. M. Hansen, M. Frey, M. G. Koziel, M. Knop, M. Zikmundova, N. Gerber, N. J. Whitney, O. Wahlroos, P. A. Hedin, Q. Yue, R. M. Couture, R. T. Riley, R. T. Riley, R. W. Gagliardo, S. Martyniuk, S. S. Krogh, S. V. Copaja, T. Kommedahl, V. Cambier, V. H. Argandona, V. Vilich, W. F. O. Marasas, W. F. O. Marasas   +55 more
core   +2 more sources

Pre-Existing Liver Disease and Toxicity of Antifungals

Journal of Fungi, 2018
Pre-existing liver disease in patients with invasive fungal infections further complicates their management. Altered pharmacokinetics and tolerance issues of antifungal drugs are important concerns.
Nikolaos Spernovasilis, Diamantis P. Kofteridis   +1 more
doaj   +1 more source

Small, Cationic Antifungal Proteins from Filamentous Fungi Inhibit Candida albicans Growth in 3D Skin Infection Models

Microbiology Spectrum, 2022
The emerging resistance of human-pathogenic fungi to antifungal drugs urges the development of alternative therapeutic strategies. The small, cationic antifungal proteins (AFPs) from filamentous ascomycetes represent promising candidates for next ...
Jeanett Holzknecht, Sandrine Dubrac, Sarah Hedtrich, László Galgóczy, Florentine Marx   +4 more
doaj   +1 more source

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source

Loss of the Aspergillus fumigatus spindle assembly checkpoint components, SldA or SldB, generates triazole heteroresistant conidial populations

Microbiology Spectrum
The opportunistic pathogen Aspergillus fumigatus is the chief causative agent of human invasive filamentous fungal infections. Triazoles, the primary therapeutic options to combat invasive aspergillosis (IA), target the biosynthesis of ergosterol, a ...
Ashley V. Nywening, Harrison I. Thorn, Jinhong Xie, Adela Martin-Vicente, Xabier Guruceaga, Wenbo Ge, John G. Gibbons, Jarrod R. Fortwendel   +7 more
doaj   +1 more source

Resistance to the Plant Defensin NaD1 Features Modifications to the Cell Wall and Osmo-Regulation Pathways of Yeast

Frontiers in Microbiology, 2018
Over the last few decades, the emergence of resistance to commonly used antifungal molecules has become a major barrier to effective treatment of recurrent life-threatening fungal diseases.
Amanda I. McColl, Mark R. Bleackley, Marilyn A. Anderson, Rohan G. T. Lowe   +3 more
doaj   +1 more source