Results 11 to 20 of about 1,778,950 (367)
Learned features of antibody-antigen binding affinity
Frontiers in Molecular Biosciences, 2023 Defining predictors of antigen-binding affinity of antibodies is valuable for engineering therapeutic antibodies with high binding affinity to their targets.
Nathaniel L. Miller +7 more
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Application of fluorescein copolymer to improve the efficiency of counter-immunoelectrophoresis for diagnostics of animal infectious diseases [PDF]
The Ukrainian Biochemical Journal, 2021 The counter-immunoelectrophoresis (CIE) is a highly specific, simple and rapid method, which does not require expensive equipment, input materials and long-term staff training as compared with other express methods of viral infections diagnostic. Despite
D. D. Ostapiv +9 more
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NbX: Machine Learning-Guided Re-Ranking of Nanobody–Antigen Binding Poses
Pharmaceuticals, 2021 Modeling the binding pose of an antibody is a prerequisite to structure-based affinity maturation and design. Without knowing a reliable binding pose, the subsequent structural simulation is largely futile.
Chunlai Tam +2 more
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bioRxiv, 2023 High resolution antibody-antigen structures provide critical insights into immune recognition and can inform therapeutic design. The challenges of experimental structural determination and the diversity of the immune repertoire underscore the necessity ...
Rui Yin, B. Pierce
semanticscholar +2 more sources
mAbs, 2021 Therapeutic proteins including antibodies and Fc-fusion proteins undergo a large number of chemical modifications during cell culture, purification, storage and in human circulation.
Pavel V. Bondarenko +8 more
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Design of Antibody-Functionalized Polymeric Membranes for the Immunoisolation of Pancreatic Islets
Applied Sciences, 2020 An immunoencapsulation strategy for pancreatic islets aimed to reduce the risk of rejection in transplanted patients due to the immune response of the host organism is proposed.
Anna Cavallo +7 more
doaj +1 more source
Frontiers in Chemistry, 2022 Asparagine deamidation and aspartic acid isomerization in the complementarity determining regions (CDRs) of monoclonal antibodies may alter their affinity to the target antigen.
Baubek Spanov +6 more
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Surface Properties of Antigen–Antibody Complexes [PDF]
Scandinavian Journal of Immunology, 1997 In this paper, the authors show that liquid–liquid partition chromatography in an aqueous two‐phase system offers unique possibilities of comparing the overall surface properties of intact antibodies in solution before and after binding of antigen. The authors demonstrate that the surface properties of antigen–antibody complexes are dependent on the ...
C, Wingren, U B, Hansson
openaire +2 more sources
Quantitative Description of Surface Complementarity of Antibody-Antigen Interfaces
Frontiers in Molecular Biosciences, 2021 Antibodies have the remarkable ability to recognise their cognate antigens with extraordinary affinity and specificity. Discerning the rules that define antibody-antigen recognition is a fundamental step in the rational design and engineering of ...
Lorenzo Di Rienzo +5 more
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Foods, 2022 Immunomagnetic beads (IMBs) have been widely used to capture and isolate target pathogens from complex food samples. The orientation of the antibody immobilized on the surface of magnetic beads (MBs) is closely related to the effective recognition with ...
Fuying Kang +6 more
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