Structural consensus among antibodies defines the antigen binding site. [PDF]
PLoS Computational Biology, 2012 The Complementarity Determining Regions (CDRs) of antibodies are assumed to account for the antigen recognition and binding and thus to contain also the antigen binding site.
Vered Kunik, Bjoern Peters, Yanay Ofran
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The biological activity of soluble antigen-antibody complexes: II. Physical properties of soluble complexes having skin-irritating activity [PDF]
, 1959 Previous work by Germuth and McKinnon (1), Trapani et al. (2), and ourselves (3) has established the fact that soluble antigen-antibody complexes formed in excess antigen can, (a) induce symptoms similar to anaphylaxis, (b) cause contraction of isolated ...
Campbell, Dan H. +2 more
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Improved Diagnosis of Tuberculous Meningitis Using a Combination of Multiplex Antigens and Antibodies Testing Methods [PDF]
Journal of Clinical and Diagnostic Research, 2021 Introduction: Various serological assays exists, including Antigen and Antibody detection (IgM and IgG) for diagnosis of Tuberculous Meningitis (TBM) cases.
Amit Raju Nayak +7 more
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A combined computational-experimental approach to define the structural origin of antibody recognition of sialyl-Tn, a tumor-associated carbohydrate antigen. [PDF]
, 2018 Anti-carbohydrate monoclonal antibodies (mAbs) hold great promise as cancer therapeutics and diagnostics. However, their specificity can be mixed, and detailed characterization is problematic, because antibody-glycan complexes are challenging to ...
Amon, Ron +12 more
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Assessment of serum selenium and ceruloplasmin in potentially malignant disorders and oral cancer
Journal of Pharmacy and Bioallied Sciences, 2021 Introduction: Despite extensive research and development, potentially malignant disorders (PMDs) of the oral cavity and oral cancer remain a serious concern.
Mathew O Mampilly +5 more
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In Silico Methods in Antibody Design
Antibodies, 2018 Antibody therapies with high efficiency and low toxicity are becoming one of the major approaches in antibody therapeutics. Based on high-throughput sequencing and increasing experimental structures of antibodies/antibody-antigen complexes, computational
Jun Zhao +3 more
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The COVID Complex: A Review of Platelet Activation and Immune Complexes in COVID-19
Frontiers in Immunology, 2022 Coronavirus disease 2019 (COVID-19) is a highly prothrombotic viral infection that primarily manifests as an acute respiratory syndrome. However, critically ill COVID-19 patients will often develop venous thromboembolism with associated increases in ...
Stefan D. Jevtic, Ishac Nazy, Ishac Nazy
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Immune-Complex Mimics as a Molecular Platform for Adjuvant-Free Vaccine Delivery [PDF]
, 2013 Protein-based vaccine development faces the difficult challenge of finding robust yet non-toxic adjuvants suitable for humans. Here, using a molecular engineering approach, we have developed a molecular platform for generating self-adjuvanting immunogens
A Demissie +68 more
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The Modified Vaccination Technique
Vaccines, 2018 In addition to active and passive immunizations, there is a third method of immunization, the modified vaccination technique, which is based on injecting a combination of target antigens and antibodies against this antigen.
Arpad Barabas +4 more
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Isolation of Circulating Immune Complexes from TB Patient Serum for Serodiagnosis
Bio-Protocol, 2012 Estimation of circulating immune complex in tuberculosis patients has shown better insight to the infection. Isolating circulating immune complex helps quantifying both antigen and antibody in the serum. It’s a simple procedure to improve the sensitivity
Uma Ranganathan +2 more
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