Results 221 to 230 of about 3,030,865 (307)

SphB1 export system for antigen presentation to the respiratory tract by a live pertussis vaccine. [PDF]

Appl Microbiol Biotechnol
Santiesteban-Lores LE, Raze D, Dubois V, Tardy M, Debrie AS, Goldstein P, Coutte L, Locht C.   +7 more
europepmc   +1 more source

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

M13 phage-based antigen presentation and immune response activation in vaccine development for animal infectious diseases. [PDF]

Front Immunol
Zhou G, Zhang J, Zhang Z, Cao S, Li Y.
europepmc   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Sorting nexin 5 deficiency impairs MHC class II antigen presentation and inflammatory responses during tuberculosis. [PDF]

J Immunol
Dias BRS, Naqvi KF, Ektnitphong VA, Alvarez-Arguedas S, Rahlwes KC, Campos PC, Shiloh MU.   +6 more
europepmc   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

PICALM regulates a human microglial antigen presentation program in Alzheimer’s disease

De Strooper B, Borrie S, Pasciuto E, Moortel LV, Willems P, Moechars D, Thrupp N, Bourdely P, Snellinx A, T'Syen D, Li R, Lloyd A, Geary B, De Baene H, Albertini G, Sirvent DÁ, Mekkes N, Holtman I, Holstege H, Malysheva V, Mazzone M, Impens F, Fiers M, Sierksma A.   +23 more
europepmc   +1 more source

Cancer Immune Responsiveness and MHC Class I Antigen Presentation: Mechanisms of Immune Escape and Immunotherapy Resistance in Gastrointestinal Cancers. [PDF]

Cells
Grizzi F, Chiriva-Internati M, Hegazi MAAA, Rubbino F, Pasqualini F, Spadaccini M, Andreozzi M, Mercurio M, Cassano F, Terrin M, Hassan C, Bresalier RS, Repici A, Carrara S.   +13 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source