Results 241 to 250 of about 3,030,865 (307)

An Activity‐Reinforced P‐Modified Single‐Atom Cu Nanozyme Potentiates IDO Blockade‐Induced Tumor Radiotherapy

Advanced Science, EarlyView.
A phosphorus‐modified single‐atom copper nanozyme delivering the IDO1 inhibitor 1‐methyl‐tryptophan enhances breast cancer radioimmunotherapy by simultaneously relieving hypoxia and inducing immunogenic cell death through dual enzyme activities while blocking tryptophan metabolism to suppress regulatory T cell function.
Wei Zhao, Songliu Hu, Zhanggui Wang, Liqun Wang, Liming Zhang, Qi Li, Hua Tang, Yang Zhong, Zhongxian Zhang, Kelong Fan, Shipeng Ning, Xiyun Yan   +11 more
wiley   +1 more source

Engineering high-fidelity tapasin variants to enhance MHC-I antigen presentation. [PDF]

J Biol Chem
Erdman MC, Epstein K, Hwang D, Khan RMM, Sun SM, Sgourakis NG.   +5 more
europepmc   +1 more source

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

Advanced Science, EarlyView.
This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang, Jiani Deng, Man Yee Cheung, Tingting Fu, Xufeng Qi, Dongqing Cai, Jianmin Sun, Gang Lu, Peng Shi, Wai‐Yee Chan, Xu Li, Hui Zhao   +11 more
wiley   +1 more source

Immune evasion driven by lipid metabolic reprogramming in endocrine-resistant HR⁺ breast cancer: antigen presentation defects and T-cell dysfunction. [PDF]

Front Immunol
Gong L, Zhao Y, Che M, Zhang X, Zhang D, Lu W.   +5 more
europepmc   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Linker-directed lipid-antigen conjugates co-enhance lymph node targeting and antigen presentation for potent T cell immunity. [PDF]

Mater Today Bio
Zhu J, Bai L, Wang C, Liu J, Chen Y, Zhang W, Weng J, Wei L, Wei Z.   +8 more
europepmc   +1 more source

In Vitro Selection of Antibodies Targeting <i>Yersinia pestis</i> Membrane Lipids Using Nanodisc-Based Antigen Presentation. [PDF]

Pathogens
Bolding MR, Mozden SC, Pimentel OR, Montoya MM, Kubicek-Sutherland JZ, Velappan N.   +5 more
europepmc   +1 more source

IFNγ regulates MR1 transcription and antigen presentation. [PDF]

Front Immunol
Huber ME, Larson EA, Lust TN, Heisler CM, Harriff MJ.   +4 more
europepmc   +1 more source