Overcoming impaired antigen presentation in tumor-draining lymph nodes facilitates immunotherapy. [PDF]
O'Melia MJ +14 more
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An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao +18 more
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Stress-driven remodeling of antigen presentation and chemokine signaling in pancreatic β-cells: implications for type 1 diabetes. [PDF]
Mittal R +4 more
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Fibroblast-specific ablation of MHC-I antigen presentation via the IGF2 axis cripples CD8<sup>+</sup> T cell surveillance in lung cancer. [PDF]
Song D +15 more
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DNA damage in macrophages drives immune autoreactivity via nuclear antigen presentation. [PDF]
Niotis G +10 more
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Ferroptotic tumor cells reprogram tumor-associated macrophage antigen presentation to enhance the efficacy of immune checkpoint blockade. [PDF]
Sun JL +17 more
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Correction to "Outer Membrane Vesicles from Caulobacter crescentus: A Platform for Recombinant Antigen Presentation". [PDF]
Ginez LD +6 more
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Neoself-antigen presentation in SLE: Mordred's coronation in Arthur's absence. [PDF]
Pazhouhandeh M, Sun H, Yu D.
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Monoclonal antibodies specific for defined peptide-MHC complexes are now being used to physically detect T-cell receptor ligands. These reagents have resulted in the identification of the cells that present antigen in lymphoid and non-lymphoid tissues after various forms of antigen administration.
Ronald N, Germain, Marc K, Jenkins
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Antigen presentation, antigen-presenting cells and antigen processing
Current Opinion in Immunology, 1988To summarize, during the period under review there have been considerable advances in our understanding of how antigen is associated with MHC on the surface of a presenting cell. Basic rules which govern this association have been confirmed as including both the nature and the configuration of the antigen.
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