Results 41 to 50 of about 522,409 (333)

The Role of FcRn in Antigen Presentation [PDF]

Frontiers in Immunology, 2014
Immunoglobulins are unique molecules capable of simultaneously recognizing a diverse array of antigens and themselves being recognized by a broad array of receptors. The abundance specifically of the IgG subclass and the variety of signaling receptors to which it binds render this an important immunomodulatory molecule. In addition to the classical Fcγ
Kristi eBaker, Timo eRath, Timo eRath, Michal ePyzik, Richard S. Blumberg   +4 more
openaire   +6 more sources

Efficient Capsid Antigen Presentation From Adeno-Associated Virus Empty Virions In Vivo

Frontiers in Immunology, 2018
Adeno-associated virus (AAV) vectors have been successfully applied in clinical trials for hemophilic patients. Although promising, the clinical results suggest that the capsid-specific CD8+T cell response has a negative effect on therapeutic success. In
Xiaolei Pei, Xiaolei Pei, Lauriel Freya Earley, Yi He, Yi He, Xiaojing Chen, Nikita Elexa Hall, Richard Jude Samulski, Richard Jude Samulski, Chengwen Li, Chengwen Li   +10 more
doaj   +1 more source

Vaccine delivery by penetratin: mechanism of antigen presentation by dendritic cells [PDF]

, 2016
Cell-penetrating peptides (CPP) or membrane-translocating peptides such as penetratin from Antennapedia homeodomain or TAT from human immunodeficiency virus are useful vectors for the delivery of protein antigens or their cytotoxic (Tc) or helper (Th) T ...
A Lenarczyk, BC Gil-Torregrosa, BP Gross, C Bechara, C Jacobs, CC Norbury, CC Norbury, Choon-Kit Tang, CM Fehres, Dodie Pouniotis, DS Pouniotis, DS Pouniotis, DT Kim, E Koren, E Vives, F Wang, G Fenteany, GA Pietersz, Geoffrey Pietersz, GG Chikh, H Umezawa, H Yang, HY Wang, I Melero, I Mellman, J Chen, J Lu, J Lu, J Pohl, JC Mai, JE Schnitzer, JP Richard, JS Blum, JS Park, K Palucka, KC Sheng, L Cohn, L Delamarre, LJ Cruz, M Kovacsovics-Bankowski, M Mansourian, MA Morse, MA West, MM Fretz, MP Schutze-Redelmeier, MP Schutze-Redelmeier, MV Dhodapkar, N Brooks, N Merzougui, N Shibagaki, NA Brooks, NA Brooks, OP Joffre, P Midoux, P Sampath, PA Orlandi, PJ Tacken, R Wallbrecher, S Kozlowski, S Sanderson, S Vassilaros, SM Farkhani, T Buhl, T Wileman, TB Potocky, V Apostolopoulos, V Apostolopoulos, V Apostolopoulos, Vasso Apostolopoulos, W Kastenmuller, WF Lo, X Wu, Y Cho, Y Jiang, Z Yang   +74 more
core   +1 more source

Antigen presentation by MHC-dressed cells

Frontiers in Immunology, 2015
Professional antigen presenting cells (APCs) such as conventional dendritic cells (DCs) process protein antigens to MHC-bound peptides and then present the peptide-MHC complexes to T cells.
Masafumi eNakayama
doaj   +1 more source

Tumor-derived microvesicles modulate antigen cross-processing via reactive oxygen species-mediated alkalinization of phagosomal compartment in dendritic cells [PDF]

, 2017
Dendritic cells (DCs) are the only antigen-presenting cells able to prime naïve T cells and cross-prime antigen-specific CD8+ T cells. Their functionality is a requirement for the induction and maintenance of long-lasting cancer immunity.
Aurelia Rughetti, Chiara Napoletano, Fabio Altieri, Federico Battisti, Filippo Bellati, Filippo Bellati, Francesca Belleudi, Giulio Caracciolo, Hassan Rahimi Koshkaki, Ilaria Grazia Zizzari, Ilary Ruscito, Ilary Ruscito, Maria Rosaria Torrisi, Maria Rosaria Torrisi, Marianna Nuti, Pierluigi Benedetti Panici, Sara Palchetti   +16 more
core   +2 more sources

Making Antigen Presentable [PDF]

The Journal of Immunology, 2007
In the late 1960s and early 1970s, a shift occurred in the focus of immunological research from Ab-dominated studies to ones involving cellular components of immunity such as T cells, B cells, and APCs.
openaire   +2 more sources

Assessment of In Vitro Immunostimulatory Activity of an Adjuvanted Whole-Cell Inactivated Neisseria gonorrhoeae Microparticle Vaccine Formulation

Vaccines, 2022
The emergence of drug-resistant gonorrhea infections worldwide combined with the lack of a vaccine is alarming. We prepared a novel microparticulate (MP) vaccine formulation using whole-cell inactivated Neisseria gonorrhoeae as the vaccine antigen, with ...
Priyal Bagwe, Lotika Bajaj, Rikhav P. Gala, Martin J. D‘Souza, Susu M. Zughaier   +4 more
doaj   +1 more source

A novel HLA-B18 restricted CD8+ T cell epitope is efficiently cross-presented by dendritic cells from soluble tumor antigen [PDF]

, 2012
NY-ESO-1 has been a major target of many immunotherapy trials because it is expressed by various cancers and is highly immunogenic. In this study, we have identified a novel HLA-B*1801-restricted CD8⁺T cell epitope, NY-ESO-1<sub&
Ashley J. Knights, Emmanuel Scotet, Eugene Maraskovsky, Heather M. Jackson, Ian D. Davis, Immanuel F. Luescher, Jonathan Cebon, Kok-Fei Chan, Kun Xiao, Neil C. Robson, Nektaria Dimopoulos, Nicole A. Mifsud, Philippe Guillaume, Rona Y. Zhao, Sara Oveissi, Sarah E. Russell, Sylvie Le Gall, Tamara Lowen, Weisan Chen   +18 more
core   +10 more sources

Surface-associated antigen induces permeabilization of primary mouse B-cells and lysosome exocytosis facilitating antigen uptake and presentation to T-cells

eLife, 2021
B-cell receptor (BCR)-mediated antigen internalization and presentation are essential for humoral memory immune responses. Antigen encountered by B-cells is often tightly associated with the surface of pathogens and/or antigen-presenting cells ...
Fernando Y Maeda, Jurriaan JH van Haaren, David B Langley, Daniel Christ, Norma W Andrews, Wenxia Song   +5 more
doaj   +1 more source

Heat Shock Protein Magic in Antigen Trafficking within Dendritic Cells:Implications in Antigen Cross-presentation in Immunity [PDF]

, 2012
Dendritic cells (DCs) take up soluble- or cell-associated antigens and digest them, delivering fragments to the MHC class I pathway to display antigenic peptides to CD8＋ T cells, a process known as cross-presentation.
Udono, Heiichiro
core   +1 more source