Promising Extracellular Vesicle-Based Vaccines against Viruses, Including SARS-CoV-2
Biology, 2021 Extracellular vesicles (EVs) are secreted from almost all human cells and mediate intercellular communication by transferring heterogeneous molecules (i.e., DNA, RNAs, proteins, and lipids).
Berina Sabanovic +3 more
doaj +1 more source
MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation.
Journal of Clinical Investigation, 2020 Immune evasion is a pivotal event in tumor progression. To eliminate human cancer cells, current immune checkpoint therapy is set to boost the CD8+ T cell-mediated cytotoxicity. However, this action is eventually dependent on the efficient recognition of
Yuanzhang Fang +20 more
semanticscholar +1 more source
HLA-E Peptide Repertoire and Dimorphism—Centerpieces in the Adaptive NK Cell Puzzle?
Frontiers in Immunology, 2018 Adaptive Natural Killer (NK) cells, a heterogenous subpopulation of human NK cells with a unique phenotypic and functional signature, became arguably one of the central areas of interest in the field.
Alexander Rölle +4 more
doaj +1 more source
Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation. [PDF]
, 2018 Both adjuvants and focal ablation can alter the local innate immune system and trigger a highly effective systemic response. Our goal is to determine the impact of these treatments on directly treated and distant disease and the mechanisms for the ...
Borowsky, Alexander D +13 more
core +1 more source
The ABCs of Antigen Presentation by Stromal Non-Professional Antigen-Presenting Cells [PDF]
International Journal of Molecular Sciences, 2021 Professional antigen-presenting cells (APCs), such as dendritic cells and macrophages, are known for their ability to present exogenous antigens to T cells. However, many other cell types, including endothelial cells, fibroblasts, and lymph node stromal cells, are also capable of presenting exogenous antigens to either CD8+ or CD4+ T cells via cross ...
Tom J. Harryvan +3 more
openaire +3 more sources
Immunological responses and actin dynamics in macrophages are controlled by N-cofilin but are independent from ADF. [PDF]
PLoS ONE, 2012 Dynamic changes in the actin cytoskeleton are essential for immune cell function and a number of immune deficiencies have been linked to mutations, which disturb the actin cytoskeleton.
Friederike Jönsson +4 more
doaj +1 more source
Regulation of B cell fate by chronic activity of the IgE B cell receptor. [PDF]
, 2016 IgE can trigger potent allergic responses, yet the mechanisms regulating IgE production are poorly understood. Here we reveal that IgE+ B cells are constrained by chronic activity of the IgE B cell receptor (BCR).
Allen, Christopher DC +6 more
core +1 more source
NLRC5, at the Heart of Antigen Presentation [PDF]
Frontiers in Immunology, 2013 Nucleotide-binding domain and leucine-rich repeat containing receptors (NLRs) are intracellular proteins mainly involved in pathogen recognition, inflammatory responses, and cell death. Until recently, the function of the family member NLR caspase recruitment domain (CARD) containing 5 (NLRC5) has been a matter of debate.
Neerincx Andreas +3 more
openaire +5 more sources
The role of insulin-regulated aminopeptidase in MHC class I antigen presentation
Frontiers in Immunology, 2012 Production of MHC I ligands from antigenic proteins generally requires multiple proteolytic events. While the proteolytic steps required for antigen processing in the endogenous pathway are clearly established, persisting gaps of knowledge regarding ...
Peter M Van Endert, Loredana eSaveanu
doaj +1 more source
Antigen Stability Controls Antigen Presentation [PDF]
Journal of Biological Chemistry, 2004 We investigated whether protein stability controls antigen presentation using a four disulfide-containing snake toxin and three derivatives carrying one or two mutations (L1A, L1A/H4Y, and H4Y). These mutations were anticipated to increase (H4Y) or decrease (L1A) the antigen non-covalent stabilizing interactions, H4Y being naturally and frequently ...
Jean-Luc Tarride +6 more
openaire +3 more sources