Results 61 to 70 of about 1,150,441 (351)

A stochastic individual-based model to explore the role of spatial interactions and antigen recognition in the immune response against solid tumours [PDF]

, 2019
Spatial interactions between cancer and immune cells, as well as the recognition of tumour antigens by cells of the immune system, play a key role in the immune response against solid tumours. The existing mathematical models generally focus only on one of these key aspects.
arxiv   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Surface-associated antigen induces permeabilization of primary mouse B-cells and lysosome exocytosis facilitating antigen uptake and presentation to T-cells

eLife, 2021
B-cell receptor (BCR)-mediated antigen internalization and presentation are essential for humoral memory immune responses. Antigen encountered by B-cells is often tightly associated with the surface of pathogens and/or antigen-presenting cells ...
Fernando Y Maeda, Jurriaan JH van Haaren, David B Langley, Daniel Christ, Norma W Andrews, Wenxia Song   +5 more
doaj   +1 more source

Vaccine delivery by penetratin: mechanism of antigen presentation by dendritic cells [PDF]

, 2016
Cell-penetrating peptides (CPP) or membrane-translocating peptides such as penetratin from Antennapedia homeodomain or TAT from human immunodeficiency virus are useful vectors for the delivery of protein antigens or their cytotoxic (Tc) or helper (Th) T ...
A Lenarczyk, BC Gil-Torregrosa, BP Gross, C Bechara, C Jacobs, CC Norbury, CC Norbury, Choon-Kit Tang, CM Fehres, Dodie Pouniotis, DS Pouniotis, DS Pouniotis, DT Kim, E Koren, E Vives, F Wang, G Fenteany, GA Pietersz, Geoffrey Pietersz, GG Chikh, H Umezawa, H Yang, HY Wang, I Melero, I Mellman, J Chen, J Lu, J Lu, J Pohl, JC Mai, JE Schnitzer, JP Richard, JS Blum, JS Park, K Palucka, KC Sheng, L Cohn, L Delamarre, LJ Cruz, M Kovacsovics-Bankowski, M Mansourian, MA Morse, MA West, MM Fretz, MP Schutze-Redelmeier, MP Schutze-Redelmeier, MV Dhodapkar, N Brooks, N Merzougui, N Shibagaki, NA Brooks, NA Brooks, OP Joffre, P Midoux, P Sampath, PA Orlandi, PJ Tacken, R Wallbrecher, S Kozlowski, S Sanderson, S Vassilaros, SM Farkhani, T Buhl, T Wileman, TB Potocky, V Apostolopoulos, V Apostolopoulos, V Apostolopoulos, Vasso Apostolopoulos, W Kastenmuller, WF Lo, X Wu, Y Cho, Y Jiang, Z Yang   +74 more
core   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

MediMer: a versatile do-it-yourself peptide-receptive MHC class I multimer platform for tumor neoantigen-specific T cell detection

Frontiers in Immunology
Peptide-loaded MHC class I (pMHC-I) multimers have revolutionized our capabilities to monitor disease-associated T cell responses with high sensitivity and specificity.
Marten Meyer, Marten Meyer, Marten Meyer, Christina Parpoulas, Titouan Barthélémy, Jonas P. Becker, Jonas P. Becker, Pornpimol Charoentong, Pornpimol Charoentong, Pornpimol Charoentong, Yanhong Lyu, Selina Börsig, Selina Börsig, Nadja Bulbuc, Claudia Tessmer, Claudia Tessmer, Lisa Weinacht, David Ibberson, Patrick Schmidt, Patrick Schmidt, Rüdiger Pipkorn, Stefan B. Eichmüller, Peter Steinberger, Katharina Lindner, Katharina Lindner, Isabel Poschke, Isabel Poschke, Michael Platten, Michael Platten, Michael Platten, Michael Platten, Michael Platten, Michael Platten, Stefan Fröhling, Stefan Fröhling, Stefan Fröhling, Angelika B. Riemer, Angelika B. Riemer, Jessica C. Hassel, Maria Paula Roberti, Maria Paula Roberti, Dirk Jäger, Dirk Jäger, Inka Zörnig, Inka Zörnig, Frank Momburg, Frank Momburg   +46 more
doaj   +1 more source

Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease

Frontiers in Immunology, 2018
Regulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of ~22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer.
Keli L. Hippen, Michael Loschi, Jemma Nicholls, Kelli P. A. MacDonald, Bruce R. Blazar   +4 more
doaj   +1 more source

A role for the Hsp90 molecular chaperone family in antigen presentation to T lymphocytes via major histocompatibility complex class II molecules [PDF]

, 2006
The heat shock protein (HSP) Hsp90 is known to chaperone cytosolic peptides for MHC class I (MHCI)-restricted antigen presentation to T lymphocytes. We now demonstrate a role for Hsp90 activity in presentation of antigens on MHCII.
Bal, Vineeta, George, Anna, Mayor, Satyajit, Rajagopal, Deepa, Rath, Satyajit   +4 more
core   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source