Results 61 to 70 of about 3,190,099 (375)
Making Antigen Presentable [PDF]
The Journal of Immunology, 2007 In the late 1960s and early 1970s, a shift occurred in the focus of immunological research from Ab-dominated studies to ones involving cellular components of immunity such as T cells, B cells, and APCs.
openaire +2 more sources
Tumor-derived microvesicles modulate antigen cross-processing via reactive oxygen species-mediated alkalinization of phagosomal compartment in dendritic cells [PDF]
, 2017 Dendritic cells (DCs) are the only antigen-presenting cells able to prime naïve T cells and cross-prime antigen-specific CD8+ T cells. Their functionality is a requirement for the induction and maintenance of long-lasting cancer immunity.
Aurelia Rughetti +16 more
core +2 more sources
Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells. [PDF]
Annual Review of Immunology, 2018 The initiation and maintenance of adaptive immunity require multifaceted modes of communication between different types of immune cells, including direct intercellular contact, secreted soluble signaling molecules, and extracellular vesicles (EVs). EVs can be formed as microvesicles directly pinched off from the plasma membrane or as exosomes secreted ...
Marthe F. S. Lindenbergh, W. Stoorvogel
semanticscholar +3 more sources
Vaccines, 2022 The emergence of drug-resistant gonorrhea infections worldwide combined with the lack of a vaccine is alarming. We prepared a novel microparticulate (MP) vaccine formulation using whole-cell inactivated Neisseria gonorrhoeae as the vaccine antigen, with ...
Priyal Bagwe +4 more
doaj +1 more source
Heat Shock Protein Magic in Antigen Trafficking within Dendritic Cells:Implications in Antigen Cross-presentation in Immunity [PDF]
, 2012 Dendritic cells (DCs) take up soluble- or cell-associated antigens and digest them, delivering fragments to the MHC class I pathway to display antigenic peptides to CD8＋ T cells, a process known as cross-presentation.
Udono, Heiichiro
core +1 more source
Fc Gamma Receptors and Their Role in Antigen Uptake, Presentation, and T Cell Activation
Frontiers in Immunology, 2020 The cellular uptake, intracellular processing, and presentation of foreign antigen are crucial processes for eliciting an effective adaptive host response to the majority of pathogens.
F. Junker, J. Gordon, O. Qureshi
semanticscholar +1 more source
Frontiers in Immunology, 2017 Antigen presentation by major histocompatibility complex (MHC) proteins is essential for adaptive immunity. Prior to presentation, peptides need to be generated from proteins that are either produced by the cell’s own translational machinery or that are ...
M. Wieczorek +6 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
Resistance to checkpoint blockade therapy through inactivation of antigen presentation
Nature Communications, 2017 Treatment with immune checkpoint blockade (CPB) therapies often leads to prolonged responses in patients with metastatic melanoma, but the common mechanisms of primary and acquired resistance to these agents remain incompletely characterized and have yet
Moshe Sade-Feldman +30 more
semanticscholar +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source