Results 71 to 80 of about 3,190,099 (375)

MediMer: a versatile do-it-yourself peptide-receptive MHC class I multimer platform for tumor neoantigen-specific T cell detection

Frontiers in Immunology
Peptide-loaded MHC class I (pMHC-I) multimers have revolutionized our capabilities to monitor disease-associated T cell responses with high sensitivity and specificity.
Marten Meyer, Marten Meyer, Marten Meyer, Christina Parpoulas, Titouan Barthélémy, Jonas P. Becker, Jonas P. Becker, Pornpimol Charoentong, Pornpimol Charoentong, Pornpimol Charoentong, Yanhong Lyu, Selina Börsig, Selina Börsig, Nadja Bulbuc, Claudia Tessmer, Claudia Tessmer, Lisa Weinacht, David Ibberson, Patrick Schmidt, Patrick Schmidt, Rüdiger Pipkorn, Stefan B. Eichmüller, Peter Steinberger, Katharina Lindner, Katharina Lindner, Isabel Poschke, Isabel Poschke, Michael Platten, Michael Platten, Michael Platten, Michael Platten, Michael Platten, Michael Platten, Stefan Fröhling, Stefan Fröhling, Stefan Fröhling, Angelika B. Riemer, Angelika B. Riemer, Jessica C. Hassel, Maria Paula Roberti, Maria Paula Roberti, Dirk Jäger, Dirk Jäger, Inka Zörnig, Inka Zörnig, Frank Momburg, Frank Momburg   +46 more
doaj   +1 more source

Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease

Frontiers in Immunology, 2018
Regulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of ~22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer.
Keli L. Hippen, Michael Loschi, Jemma Nicholls, Kelli P. A. MacDonald, Bruce R. Blazar   +4 more
doaj   +1 more source

Surface-associated antigen induces permeabilization of primary mouse B-cells and lysosome exocytosis facilitating antigen uptake and presentation to T-cells

eLife, 2021
B-cell receptor (BCR)-mediated antigen internalization and presentation are essential for humoral memory immune responses. Antigen encountered by B-cells is often tightly associated with the surface of pathogens and/or antigen-presenting cells ...
Fernando Y Maeda, Jurriaan JH van Haaren, David B Langley, Daniel Christ, Norma W Andrews, Wenxia Song   +5 more
doaj   +1 more source

Antigen presentation and tumor immunogenicity in cancer immunotherapy response prediction

eLife, 2019
Immunotherapy, represented by immune checkpoint inhibitors (ICI), is transforming the treatment of cancer. However, only a small percentage of patients show response to ICI, and there is an unmet need for biomarkers that will identify patients who are ...
Shixiang Wang, Zaoke He, Xuan Wang, Huimin Li, Xue-song Liu   +4 more
semanticscholar   +1 more source

Autophagy and antigen presentation [PDF]

Cellular Microbiology, 2006
CD4(+) T cells co-ordinate adaptive immunity and are required for immunological memory establishment and maintenance. They are thought to primarily recognize extracellular antigens, which are endocytosed, processed by lysosomal proteases and then presented on major histocompatibility complex (MHC) class II.
openaire   +2 more sources

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Short-term antigen presentation and single clonal burst limit the magnitude of the CD8(+) T cell responses to malaria liver stages.

, 2002
Malaria sporozoites induce swift activation of antigen-specific CD8(+) T cells that inhibit the intracellular development of liver-stage parasites. The length of time of functional in vivo antigen presentation, estimated by monitoring the activation of ...
A. Morrot, Ahmed, Altman, Bruno, Bru  a-Romero, Busch, Carvalho, Carvalho, Clyde, F. Zavala, G.-i. Sano, Gilbert, Goossens, Gray, Herrington, Hou, J. C. R. Hafalla, Kaech, Kundig, L. H. Carvalho, Lalvani, Lau, Li, Mercado, Mullbacher, Murali-Krishna, Oehen, Oliveira-Ferreira, Plebanski, Plebanski, Renggli, Rodrigues, Rodrigues, Rodrigues, Rodrigues, Romero, Scheller, Schneider, Sedegah, Shinkai, Tanchot, van Stipdonk, Vanderberg, Veiga-Fernandes, Weiss   +44 more
core   +2 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Genetics of antigen processing and presentation [PDF]

Immunogenetics, 2018
Immune response to disease requires coordinated expression of an army of molecules. The highly polymorphic MHC class I and class II molecules are key to control of specificity of antigen presentation. Processing of the antigen, to peptides or other moieties, requires other sets of molecules. For classical class I, this includes TAP peptide transporters,
Kelly, Adrian, Trowsdale, John
openaire   +3 more sources

Immunogens and Antigen Processing: Report from a Global HIV Vaccine Enterprise Working Group [PDF]

, 2010
The Global HIV Vaccine Enterprise convened a meeting of a Working Group in July 2009 to discuss recent progress in rational design of the components of an HIV vaccine, such as inserts, vectors and adjuvants,and in understanding antigen processing and ...
John Mascola, Ralph Steinman, Richter C. King, the Working Group convened by the Global HIV Vaccine Enterprise   +3 more
core   +3 more sources