Results 21 to 30 of about 122,331 (271)

Mosaic VSGs and the scale of Trypanosoma brucei antigenic variation.

PLoS Pathogens, 2013
A main determinant of prolonged Trypanosoma brucei infection and transmission and success of the parasite is the interplay between host acquired immunity and antigenic variation of the parasite variant surface glycoprotein (VSG) coat.
James P J Hall, Huanhuan Wang, J David Barry   +2 more
doaj   +1 more source

Antigenic variation in the African trypanosome: molecular mechanisms and phenotypic complexity [PDF]

, 2009
Antigenic variation is an immune evasion strategy that has evolved in viral, bacterial and protistan pathogens. In the African trypanosome this involves stochastic switches in the composition of a variant surface glycoprotein (VSG) coat, using a massive ...
Marcello, Lucio, McCulloch, Richard, Morrison, Liam J.   +2 more
core   +1 more source

The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction [PDF]

, 2014
Babesia spp. are tick-borne, intraerythrocytic hemoparasites that use antigenic variation to resist host immunity, through sequential modification of the parasite-derived variant erythrocyte surface antigen (VESA) expressed on the infected red blood cell
Allred, David R., Berriman, Matt, Darby, Alistair, Echaide, Ignacio Eduardo, Farber, Marisa, Gahlot, Sunayna, Gamble, John, Gupta, Diness, Gupta, Yask, Hall, Neil, Jackson, Andrew P., Jackson, Louise, Lingelbach, Klaus, Malandrin, Laurence, Malas, Tareq B., Moussa, Ehab, Nair, Mridul, Otto, Thomas D., Pain, Arnab, Quail, Mike A., Ramaprasad, Abhinay, Reid, Adam J., Sanders, Mandy, Sharma, Jyotsna, Shiels, Brian, Tait, Andy, Tracey, Alan, Wastling, Jonathan M., Weir, William, Willadsen, Peter, Xia, Dong   +30 more
core   +6 more sources

Spirochetal Lipoproteins and Immune Evasion. [PDF]

, 2017
Spirochetes are a major threat to public health. However, the exact pathogenesis of spirochetal diseases remains unclear. Spirochetes express lipoproteins that often determine the cross talk between the host and spirochetes.
Boyadjian, Ani, Christodoulides, Alexei, Kelesidis, Theodoros   +2 more
core   +1 more source

Antigenic Variation in Streptococcus pneumoniae PspC Promotes Immune Escape in the Presence of Variant-Specific Immunity

mBio, 2018
Genomic analysis reveals extensive sequence variation and hot spots of recombination in surface proteins of Streptococcus pneumoniae. While this phenomenon is commonly attributed to diversifying selection by host immune responses, there is little ...
M. Georgieva, L. Kagedan, Ying-Jie Lu, C. M. Thompson, M. Lipsitch   +4 more
doaj   +1 more source

Beyond immune escape:a variant surface glycoprotein causes suramin resistance in Trypanosoma brucei [PDF]

, 2017
Suramin is one of the first drugs developed in a medicinal chemistry program (Bayer, 1916), and it is still the treatment of choice for the hemolymphatic stage of African sleeping sickness caused by Trypanosoma brucei rhodesiense.
Cal, Monica, Graf, Fabrice E., Kunz Renggli, Christina, Mäser, Pascal, Ndomba, Emiliana, Schmidt, Remo S., Wenzler, Tanja, Wiedemar, Natalie, Zwyer, Michaela   +8 more
core   +3 more sources

Dengue genetic divergence generates within-serotype antigenic variation, but serotypes dominate evolutionary dynamics

eLife, 2019
Dengue virus (DENV) exists as four genetically distinct serotypes, each of which is historically assumed to be antigenically uniform. Recent analyses suggest that antigenic heterogeneity may exist within each serotype, but its source, extent and impact ...
Sidney M Bell, Leah Katzelnick, Trevor Bedford   +2 more
doaj   +1 more source

In vivo evidence for quasispecies distributions in the bovine respiratory syncytial virus genome [PDF]

, 2007
We analyzed the genetic evolution of bovine respiratory syncytial virus (BRSV) isolate W2-00131, from its isolation in bovine turbinate (BT) cells to its inoculation in calves.
Bonnet, Marion, Deplanche, Martine, Lemaire, Mylène, Meyer, Gilles, Mirandette, Carole, Schelcher, François   +5 more
core   +1 more source

Evolution of Host Specificity by Malaria Parasites through Altered Mechanisms Controlling Genome Maintenance

mBio, 2020
The protozoan parasites that cause malaria infect a wide variety of vertebrate hosts, including birds, reptiles, and mammals, and the evolutionary pressures inherent to the host-parasite relationship have profoundly shaped the genomes of both host and ...
Michelle C. Siao, Janus Borner, Susan L. Perkins, Kirk W. Deitsch, Laura A. Kirkman   +4 more
doaj   +1 more source

Characterization and gene expression analysis of the cir multi-gene family of plasmodium chabaudi chabaudi (AS) [PDF]

, 2012
Background: The pir genes comprise the largest multi-gene family in Plasmodium, with members found in P. vivax, P. knowlesi and the rodent malaria species.
Berriman, Matthew, Brugat, Thibaut, Böhme, Ulrike, Cunningham, Deirdre, Jackson, Andrew, Langhorne, Jean, Lawton, Jennifer, Otto, Thomas Dan, Pain, Arnab, Preiser, Peter, Reid, Adam James, Yan, Yam Xue   +11 more
core   +3 more sources