Results 41 to 50 of about 122,331 (271)

A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A second allogeneic (allo‐)hematopoietic stem cell transplantation (HSCT2) is a potential curative option for pediatric patients with acute lymphoblastic leukemia (ALL) following relapse after first allogeneic transplantation (HSCT1), but its efficacy is limited by high relapse rates and transplant‐related toxicity in highly pretreated ...
Ava Momm, Imme Haubitz, Rita Beier, Martin Zimmermann, Andrej Lissat, Peter Bader, Matthias Eyrich, Jan‐Henning Klusmann, Matthias Wölfl, Paul‐Gerhardt Schlegel, Verena Wiegering   +10 more
wiley   +1 more source

Antigenic Variation in Bacterial Pathogens [PDF]

Microbiology Spectrum, 2016
ABSTRACT Antigenic variation is a strategy used by a broad diversity of microbial pathogens to persist within the mammalian host. Whereas viruses make use of a minimal proofreading capacity combined with large amounts of progeny to use random mutation for variant generation, antigenically variant bacteria have evolved mechanisms ...
Palmer, Guy H, Bankhead, Troy, Seifert, H. Steven   +2 more
openaire   +3 more sources

Sequence variation in the haemagglutinin-neuraminidase gene of human parainfluenza virus type 3 isolates in the UK [PDF]

, 1995
The sequence variation in a 934 base-pair region of the gene encoding the haemagglutinin-neuraminidase of five human parainfluenza virus type 3 (HPIV3) isolates was determined together with that of a prototype UK strain. All of the clinical isolates were
K. R. Collins, A. J. Easton, Cane, Colman, Elango, Sambrook, van Wyke Coelingh   +6 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Resurgence and predominance of G3P[8] human rotaviruses in north-central Bangladesh, 2018–2019

New Microbes and New Infections, 2020
Predominance of genotype G3P[8] rotavirus was revealed for children and adults with diarrhoea in north-central Bangladesh for a 1-year period from September 2018.
R. Mazid, M.S. Aung, S.K. Paul, F.U. Ahmad, M. Alam, M.A. Ali, P. Nath, S. Ahmed, N. Haque, M.A. Hossain, N. Kobayashi   +10 more
doaj   +1 more source

Recent advances in malaria genomics and epigenomics [PDF]

, 2016
Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, and post-genome analyses has generated step ...
Kirchner, Sebastian, Power, B. Joanne, Waters, Andrew P.   +2 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Contribution of cryptic epitopes in designing a group A streptococcal vaccine

Human Vaccines & Immunotherapeutics, 2018
A successful vaccine needs to target multiple strains of an organism. Streptococcus pyogenes is an organism that utilizes antigenic strain variation as a successful defence mechanism to circumvent the host immune response. Despite numerous efforts, there
Victoria Ozberk, Manisha Pandey, Michael F. Good   +2 more
doaj   +1 more source

Glycosylation focuses sequence variation in the influenza A virus H1 hemagglutinin globular domain. [PDF]

PLoS Pathogens, 2010
Antigenic drift in the influenza A virus hemagglutinin (HA) is responsible for seasonal reformulation of influenza vaccines. Here, we address an important and largely overlooked issue in antigenic drift: how does the number and location of glycosylation ...
Suman R Das, Pere Puigbò, Scott E Hensley, Darrell E Hurt, Jack R Bennink, Jonathan W Yewdell   +5 more
doaj   +1 more source

Analysis of symmetries in models of multi-strain infections [PDF]

, 2013
In mathematical studies of the dynamics of multi-strain diseases caused by antigenically diverse pathogens, there is a substantial interest in analytical insights.
A Fässler, A Sasaki, AL Lloyd, B Adams, B Adams, B Fiedler, BS Chan, C Castillo-Chavez, CA Pinto, CO Buckee, CO Buckee, D Earn, DG Aronson, DJ Gubler, DJ Smith, DJ Smith, EH Elbasha, H Farkas, I Melbourne, I Stewart, J Arino, J Cisternas, J Lin, JD Murray, JHP Dawes, JR Gog, JR Gog, JW Swift, K Koelle, KB Blyuss, KB Blyuss, KB Blyuss, KB Blyuss, Konstantin B. Blyuss, M Dellnitz, M Golubitsky, M Golubitsky, M Golubitsky, M Golubitsky, M Lipsitch, M Recker, M Recker, M Recker, M Recker, MGM Gomes, N Ferguson, NM Ferguson, P Minaev, P Rohani, P-L Buono, PG Smith, S Cobey, S Gupta, S Gupta, S Gupta, S Gupta, S Kryazhimsky, SA Levin, SB Halstead, V Andreasen, V Andreasen, V Calvez, V Gupta, Y Jiang   +63 more
core   +2 more sources