Protein Antigens Increase the Protective Efficacy of a Capsule-Based Vaccine against Staphylococcus aureus in a Rat Model of Osteomyelitis [PDF]
, 2014 Staphylococcus aureus is an invasive bacterial pathogen, and antibiotic resistance has impeded adequate control of infections caused by this microbe. Moreover, efforts to prevent human infections with single-component S. aureus vaccines have failed.
Buzzola, Fernanda Roxana +6 more
core +2 more sources
Focused Specificity of Intestinal Th17 Cells towards Commensal Bacterial Antigens
Nature, 2014 T-helper-17 (TH17) cells have critical roles in mucosal defence and in autoimmune disease pathogenesis. They are most abundant in the small intestine lamina propria, where their presence requires colonization of mice with microbiota.
Yi Yang +15 more
semanticscholar +1 more source
Bacterial outer membrane vesicles and vaccine applications [PDF]
, 2014 Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit remarkable potential for immunomodulation of immune responses and delivery of “self ...
Acevedo, Reinaldo +10 more
core +2 more sources
IRAK-4 and MyD88 deficiencies impair IgM responses against T-independent bacterial antigens.
Blood, 2014 IRAK-4 and MyD88 deficiencies impair interleukin 1 receptor and Toll-like receptor (TLR) signaling and lead to heightened susceptibility to invasive bacterial infections. Individuals with these primary immunodeficiencies have fewer immunoglobulin M (IgM)(
P. Maglione +12 more
semanticscholar +1 more source
Synthetic carbohydrate-based vaccines: challenges and opportunities
Journal of Biomedical Science, 2020 Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been extremely successful in preventing bacterial infections. The glycan antigens for the preparation of CPS based glycoconjugate vaccines are mainly obtained from bacterial ...
Ravinder Mettu +2 more
doaj +1 more source
Simultaneous immunization with Omp25 and L7/L12 provides protection against brucellosis in mice [PDF]
, 2020 Currently ...
Aggarwal, Somya +4 more
core +2 more sources
The uptake of soluble and particulate antigens by epithelial cells in the mouse small intestine. [PDF]
PLoS ONE, 2014 Intestinal epithelial cells (IECs) overlying the villi play a prominent role in absorption of digested nutrients and establish a barrier that separates the internal milieu from potentially harmful microbial antigens.
Savannah E Howe +4 more
doaj +1 more source
Antigen-specific acquired immunity in human brucellosis: implications for diagnosis, prognosis, and vaccine development. [PDF]
, 2012 Brucella spp., are Gram negative bacteria that cause disease by growing within monocyte/macrophage lineage cells. Clinical manifestations of brucellosis are immune mediated, not due to bacterial virulence factors.
Alessandro eSette +8 more
core +1 more source
Nature Communications, 2020 The O-antigen of LPS is known to limit the binding of antibody to bacterial surface antigens. Here the AUs show that the chemical and physical structure of the O-antigen are central factors in limiting the exposure of surface antigens to antibodies ...
C. Coral Domínguez-Medina +23 more
doaj +1 more source
Use of recombinant virus replicon particles for vaccination against Mycobacterium ulcerans disease [PDF]
, 2015 Buruli ulcer, caused by infection with Mycobacterium ulcerans, is a necrotizing disease of the skin and subcutaneous tissue, which is most prevalent in rural regions of West African countries.
Bolz, Miriam +3 more
core +3 more sources