Results 281 to 290 of about 49,482 (293)
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Abstract IA12: Combating antigen escape with CD19/CD20 bispecific CAR-T cell therapy
Cancer Immunology Research, 2017Abstract T cells expressing chimeric antigen receptors (CARs) specific for the B-cell marker CD19 have shown impressive results in the treatment of B-cell malignancies. However, multiple clinical trials have also demonstrated the vulnerability of single-input CD19 CAR-T cell therapy to antigen escape, in which patients relapse with the ...
Eugenia Zah +4 more
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Clinical cancer research : an official journal of the American Association for Cancer Research, 1999
Rituximab is a chimeric antibody with human gamma-1 and kappa constant regions and murine variable regions. It recognizes the CD20 antigen, a pan B-cell marker. Therapeutic trials in patients with B-cell non-Hodgkin's lymphoma (NHL) have shown significant efficacy with a primary response rate of 50%, and a secondary response rate of 44% after repeat ...
T A, Davis, D K, Czerwinski, R, Levy
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Rituximab is a chimeric antibody with human gamma-1 and kappa constant regions and murine variable regions. It recognizes the CD20 antigen, a pan B-cell marker. Therapeutic trials in patients with B-cell non-Hodgkin's lymphoma (NHL) have shown significant efficacy with a primary response rate of 50%, and a secondary response rate of 44% after repeat ...
T A, Davis, D K, Czerwinski, R, Levy
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CD20 antigen imaging with ¹²⁴I-rituximab PET/CT in patients with rheumatoid arthritis.
Human antibodies, 2011Visualization of the CD20-antigen expression could provide a tool to localize sites of inflammation and could be of additive value in the diagnosis, and subsequently, in the treatment follow-up of patients with rheumatoid arthritis. In this study, an anti-CD20 monoclonal antibody, rituximab (Mabthera®), was radiolabeled with ¹²⁴Iodine.
L, Tran +6 more
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Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1).
The Journal of Immunology, 1989Abstract The CD20 (B1) molecule is a differentiation Ag found only on the surface of B lymphocytes. This structurally unique phosphoprotein plays a role in the regulation of human B cell proliferation and differentiation. In this report genomic DNA clones containing the human CD20 gene were isolated and the structure of the CD20 gene ...
T F, Tedder +3 more
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Modeling anti-CD20 chimeric antigen receptor therapy in canine B cell lymphoma patients
The Journal of Immunology, 2016Abstract Chimeric antigen receptor (CAR) therapy has demonstrated great promise in treating human leukemias, but preclinical murine models are limited in their ability to predict safety and efficacy in humans. Given the rapid and on-going advances in CAR T cell technology in the laboratory, it now becomes necessary to identify and ...
M Kazim Panjwani +3 more
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CD20 antigen imaging with 124I-rituximab PET/CT in patients with rheumatoid arthritis
Human Antibodies, 2011Introduction: Visualization of the CD20-antigen expression could provide a tool to localize sites of inflammation and could be of additive value in the diagnosis, and subsequently, in the treatment follow-up of patients with rheumatoid arthritis. In this study, an anti-CD20 monoclonal antibody, rituximab (Mabthera®), was radiolabeled with 124Iodine. We
Tran, L. +6 more
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In Silico Analysis for Determination and Validation of Human CD20 Antigen 3D Structure
International Journal of Peptide Research and Therapeutics, 2017CD20 has been known as an attractive therapeutic target for refractory diseases such as B-cell chronic lymphocytic leukemia, rheumatoid arthritis and multiple sclerosis. Determining the 3D structure of the CD20 antigen could help to achieve a better deduction of its functions and its interactions with ligands.
Zahra Payandeh +3 more
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Antibody L26 recognizes an intracellular epitope on the B-cell-associated CD20 antigen.
The American journal of pathology, 1990Monoclonal antibody L26 is a highly selective marker of B cells and B-cell neoplasms in paraffin-embedded tissues, but it suffers from the drawback that the target molecule has not been identified. In this paper we provide evidence by two independent techniques that antibody L26 recognizes an intracellular epitope on the CD20 antigen (a pan B-cell ...
D Y, Mason +4 more
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[Expression of CD68 CD45RO CD20 and proliferating cell nuclear antigen in nasal polyps].
Zhonghua er bi yan hou ke za zhi, 2005To study the cellular expression of CD45RO, CD20, CD68 and proliferating cell nuclear antigen (PCNA) in nasal polyps.Nasal polyp tissues from 50 patients were evaluated for cellular expression of CD45RO, CD20, CD68 and PCNA using immunohistochemistry SP by counting the average number in 5 chosen high-power fields, Histopathological observations were ...
Xu, Wu, Li-fen, Wang, Yu-hua, Zang
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