Results 111 to 120 of about 263,581 (290)

Influenza and memory T cells : how to awake the force [PDF]

open access: yes, 2016
Annual influenza vaccination is an effective way to prevent human influenza. Current vaccines are mainly focused on eliciting a strain-matched humoral immune response, requiring yearly updates, and do not provide protection for all vaccinated individuals.
Glezen   +12 more
core   +3 more sources

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

open access: yesAdvanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source

Memory CD4 T cell subsets are kinetically heterogeneous and replenished from naive T cells at high levels [PDF]

open access: yes, 2017
Characterising the longevity of immunological memory requires establishing the rules underlying the renewal and death of peripheral T cells. However, we lack knowledge of the population structure and how self-renewal and de novo influx contribute to ...
Asquith   +47 more
core   +4 more sources

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

open access: yesAdvanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu   +7 more
wiley   +1 more source

CHARACTERISTICS OF LYMPHOCYTE SUBPOPULATION COMPOSITION IN CANCER PATIENTS UNDERGOING COMBINED MODALITY TREATMENT INCLUDING ADAPTIVE IMMUNOTHERAPY

open access: yesСибирский онкологический журнал, 2016
Currently, cellular immunity can be estimated using the cluster of differentiation antigens or CD-markers. The panel of CD-markers including 6-8 parameters is usually used for assessment of cellular immunity.
E. V. Abakushina   +5 more
doaj  

The development and function of dendritic cell populations and their regulation by miRNAs

open access: yesProtein & Cell, 2017
Dendritic cells (DCs) are important immune cells linking innate and adaptive immune responses. DCs encounter various self and non-self antigens present in the environment and induce different types of antigen specific adaptive immune responses.
Haibo Zhou, Li Wu
doaj   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

open access: yesAdvanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth   +2 more
wiley   +1 more source

TLR Agonist Nano Immune Therapy Clears Peritoneal and Systemic Ovarian Cancer

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Intraperitoneal administration of immunogenic Toll‐like receptor agonist‐modified mesoporous silica nanoparticles leads to rapid internalization by ascites myeloid cells with trafficking to fat‐associated lymphoid clusters. Activation of myeloid cells counters suppressive immune mechanisms associated with peritoneal metastasis, leading to regional and ...
Ben Marwedel   +15 more
wiley   +1 more source

Could Increased Expression of Hsp27, an “Anti-Inflammatory” Chaperone, Contribute to the Monocyte-Derived Dendritic Cell Bias towards Tolerance Induction in Breast Cancer Patients?

open access: yesMediators of Inflammation, 2019
Dendritic cells (DCs) are the most efficient antigen-presenting cells and link the innate immune sensing of the environment to the initiation of adaptive immune responses, which may be directed to either acceptance or elimination of the recognized ...
Ana Paula Silva de Azevedo-Santos   +8 more
doaj   +1 more source

IRX-2, a Novel Immunotherapeutic, Enhances Functions of Human Dendritic Cells [PDF]

open access: yes, 2013
Background: In a recent phase II clinical trial for HNSCC patients, IRX-2, a cell-derived biologic, promoted T-cell infiltration into the tumor and prolonged overall survival. Mechanisms responsible for these IRX-2-mediated effects are unknown.
A Lopez-Albaitero   +47 more
core   +4 more sources

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