Results 101 to 110 of about 101,429 (314)

Combination of cytokine responses indicative of latent TB and active TB in Malawian adults. [PDF]

, 2013
BACKGROUND: An IFN-γ response to M. tuberculosis-specific antigens is an effective biomarker for M. tuberculosis infection but it cannot discriminate between latent TB infection and active TB disease. Combining a number of cytokine/chemokine responses to
Tom H Ottenhoff, T Mark Doherty, Dacombe, R., Ottenhoff, T.H., Crampin, Amelia C, Chaguluka, S., Hazel M Dockrell, Doherty, T.M., Tom H. Ottenhoff (475123), Amelia C Crampin, Hur, Yun-Gyoung, Crampin, Amelia C., Russell Dacombe (369437), Chaguluka Steven, Hur, Y.G., Crampin Amelia C., Anne Ben-Smith (244056), Doherty, T. Mark, Lalor, Maeve K., Lalor, M.K., Doherty T. Mark, Maeve K. Lalor (356874), Dockrell Hazel M., Ottenhoff, Tom H, Lalor, Maeve K, Kumar, Anil, Steven Chaguluka (486585), Dacombe Russell, Ottenhoff, Tom H., Gorak-Stolinska, P., Hur Yun-Gyoung, Crampin, A.C., Doherty, T Mark, T. Mark Doherty (79672), Ben-Smith, A., Ottenhoff Tom H., Lalor Maeve K., Chaguluka, Steven, Maeve K Lalor, Patricia Gorak-Stolinska (356875), Amelia C. Crampin (239427), Gorak-Stolinska, Patricia, Dacombe, Russell, Ben-Smith Anne, Ben-Smith, Anne, Dockrell, Hazel M., Steven Chaguluka, Hazel M. Dockrell (255469), Dockrell, H.M., Anne Ben-Smith, Russell Dacombe, Yun-Gyoung Hur (486584), Yun-Gyoung Hur, Gorak-Stolinska Patricia, Dockrell, Hazel M, Patricia Gorak-Stolinska   +55 more
core   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Spontaneous immune responses against glioma-associated antigens in a long term survivor with malignant glioma

Journal of Translational Medicine, 2007
Background In patients with high grade glioma, little is known regarding existence of naturally occurring adaptive T cell reactivity against glioma-associated antigens (GAAs).
Fujita Mitsugu, Zhu Xinmei, Low Keri L, Ueda Ryo, Sasaki Kotaro, Whiteside Theresa L, Butterfield Lisa H, Okada Hideho   +7 more
doaj   +1 more source

Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection

, 2002
Deletion, anergy, and a spectrum of functional impairments can affect virus-specific CD8 cells in chronic viral infections. Here we characterize a low frequency population of CD8 cells present in chronic hepatitis B virus (HBV) infection which survive in
Ogg, GS, Antonio Bertoletti, Brown, D., Dusheiko, G., Brown, D, Geoff Dusheiko, Williams, R., George J.M. Webster, Webster, GJ, Seneviratne, SL, Webster, G.J.M., Reignat, S, David Brown, Mala K. Maini, Stephanie Reignat, King, A., Dusheiko, G, Maini, MK, Bertoletti, A, Suranjith L. Seneviratne, Roger Williams, King, A, Bertoletti, A., Reignat, S., Williams, R, Maini, M.K., Graham S. Ogg, Abigail King, Ogg, G.S., Seneviratne, S.L.   +29 more
core   +1 more source

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, EarlyView.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source

Obesity-compromised immunity in post-COVID-19 condition: a critical control point of chronicity

Frontiers in Immunology
Post-COVID-19 condition is recognized as a multifactorial disorder, with persistent presence of viral antigens, discordant immunity, delayed viral clearance, and chronic inflammation.
Soonwoo Jang, Soonwoo Jang, Soonwoo Jang, Wooyoung Hong, Yuseok Moon, Yuseok Moon, Yuseok Moon, Yuseok Moon   +7 more
doaj   +1 more source

Regression of canine oral papillomas is associated with infiltration of CD4+ and CD8+ lymphocytes

, 2001
Canine oral papillomavirus (COPV) infection is used in vaccine development against mucosal papillomaviruses. The predictable, spontaneous regression of the papillomas makes this an attractive system for analysis of cellular immunity.
Nicholls, Philip K., Parry, N.R., Gough, Gerald W., Anderson, Davina M., Gough, G.W., Stanley, M.A., Parry, Nigel R., Stanley, Margaret A., Nicholls, P.K., Moore, Peter F., Moore, Richard A., Moore, R.A., Anderson, D.M., Moore, P.F.   +13 more
core   +1 more source

Consumed by Abdominal Distention

Arthritis Care &Research, EarlyView.
Abimbola Fadairo‐Azinge, James Grenert, Brian Haas, Mary Margaretten   +3 more
wiley   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source