Results 101 to 110 of about 11,845,318 (301)

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Summary of workshop findings for porcine T-lymphocyte antigens

, 1994
Fifty-four mAb preselected in the first round of the first porcine CD workshop for their possible reactivity with T-lymphocyte specific antigens and/or activation antigens were further analysed in a second round.
Canals, A., Domínguez, Javier, Goldman, T., Lunney, J. K., Maurer, S., Pescovitz, M. D., Weiland, E., Vizcaino, J., Zuckermann, F., Valpotic, I., Sánchez-Vizcaíno, J. M., Pospisil, R., Lunney, J., Weiland, Frank, Saalmüller, Armin, Dominguez, J., Pescovitz, M., Salmon, H., Saalmüller, A., Tlaskalova, H., Aasted, B.   +20 more
core   +1 more source

Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes [PDF]

, 2013
Protective responses to microorganisms involve the nonspecific but rapid defence mechanisms of the innate immune system, followed by the specific but slow defence mechanisms of the adaptive immune system. Located as sentinels at the interface between the
Cols, M, Cerutti, A, Andrea Cerutti, Puga, I, Montserrat Cols, Irene Puga   +5 more
core   +1 more source

Extracellular vesicles from seminal plasma interact with T cells in vitro and drive their differentiation into regulatory T‐cells

Journal of Extracellular Vesicles
Seminal plasma induces immune tolerance towards paternal allogenic antigens within the female reproductive tract and during foetal development. Recent evidence suggests a role for extracellular vesicles in seminal plasma (spEVs).
Xiaogang Zhang, Patrick F. Greve, Thi Tran Ngoc Minh, Richard Wubbolts, Ayşe Y. Demir, Esther A. Zaal, Celia R. Berkers, Marianne Boes, Willem Stoorvogel   +8 more
doaj   +1 more source

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

Differential dynamics of the peripheral and intrahepatic cytotoxic T lymphocyte response to hepatitis B surface antigen

Virology, 2005
The distribution and dynamics of the cytotoxic T lymphocyte (CTL) response to hepatitis B surface antigen (HBsAg) were studied in mice after intramuscular DNA immunization and after hepatic infection by a recombinant adenovirus that expresses the hepatitis B virus genome (Ad-HBV).
Isogawa, Masanori, Kakimi, Kazuhiro, Kamamoto, Hiroyuki, Protzer, Ulrike, Chisari, Francis V.   +4 more
openaire   +2 more sources

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source

CHARACTERISTICS OF LYMPHOCYTE SUBPOPULATION COMPOSITION IN CANCER PATIENTS UNDERGOING COMBINED MODALITY TREATMENT INCLUDING ADAPTIVE IMMUNOTHERAPY

Сибирский онкологический журнал, 2016
Currently, cellular immunity can be estimated using the cluster of differentiation antigens or CD-markers. The panel of CD-markers including 6-8 parameters is usually used for assessment of cellular immunity.
E. V. Abakushina, Yu. V. Marizina, G. S. Neprina, D. V. Kudryavtsev, I. A. Pasova, N. V. Selivanova   +5 more
doaj  

KLRG1+CD28⁻CD57+ Ag85A-specific CD8+ T cells mark a severity-associated terminal-differentiation imprint in pulmonary tuberculosis

Frontiers in Cellular and Infection Microbiology
BackgroundPulmonary tuberculosis (PTB) is characterized by prolonged host–pathogen interaction, chronic granulomatous inflammation, and sustained exposure to Mycobacterium tuberculosis (Mtb) antigens.
Jiaming Wu, Sufang Chen, Rui Qiang, Longji Cheng, Minyan Yao, Zhen Zhang, Xin Yu, Xin Yu, Junchi Xu, Junchi Xu, Jianping Zhang, Jianping Zhang   +11 more
doaj   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source