Results 21 to 30 of about 214,371 (284)

Commensal epitopes drive differentiation of colonic Tregs

Science Advances, 2020
Colonic commensal-derived antigens support expansion and differentiation of immunosupressive CD4 T cells. The gut microbiome is the largest source of intrinsic non–self-antigens that are continuously sensed by the immune system but typically do not ...
M. Kuczma, E. Szurek, Anna Cebula, B. Chassaing, Yu-Jin Jung, Sang-Moo Kang, J. Fox, B. Stecher, L. Ignatowicz   +8 more
semanticscholar   +1 more source

Incomplete Cd8+ T Lymphocyte Differentiation as a Mechanism for Subdominant Cytotoxic T Lymphocyte Responses to a Viral Antigen [PDF]

The Journal of Experimental Medicine, 2000
CD8+ cytotoxic T lymphocytes (CTLs) recognize antigen in the context of major histocompatibility complex (MHC) class I molecules. Class I epitopes have been classified as dominant or subdominant depending on the magnitude of the CTL response to the epitope.
Spencer, Juliet V, Braciale, Thomas J
openaire   +3 more sources

Measles Vaccines Designed for Enhanced CD8⁺ T Cell Activation

Viruses, 2020
Priming and activation of CD8+ T cell responses is crucial to achieve anti-viral and anti-tumor immunity. Live attenuated measles vaccine strains have been used successfully for immunization for decades and are currently investigated in trials of ...
Elena Busch, Kristina D. Kubon, Johanna K. M. Mayer, Gemma Pidelaserra-Martí, Jessica Albert, Birgit Hoyler, Johannes P. W. Heidbuechel, Kyle B. Stephenson, Brian D. Lichty, Wolfram Osen, Stefan B. Eichmüller, Dirk Jäger, Guy Ungerechts, Christine E. Engeland   +13 more
doaj   +1 more source

Human lymphocyte differentiation antigens HB-10 and HB-11. I. Ontogeny of antigen expression.

Journal of Immunology, 1985
T, B, and NK cells appear to represent separate lymphocyte lineages, but indirect evidence suggests that they may be related via a common lymphoid precursor cell.
T. Tedder, L. Clement, M. Cooper
semanticscholar   +1 more source

Immunological markers of arthroplasty failure

Медицинская иммунология, 2023
Periprosthetic joint infection still remains a clinical challenge since accurate definition of this condition and reliable laboratory markers have not been established yet.
O. V. Moskalets
doaj   +1 more source

Probiotic bacteria prevent Salmonella – induced suppression of lymphoproliferation in mice by an immunomodulatory mechanism

BMC Microbiology, 2017
Background Salmonella enterica infections often exhibit a form of immune evasion. We previously observed that probiotic bacteria could prevent inhibition of lymphoproliferation and apoptosis responses of T cells associated with S.
R. Doug Wagner, Shemedia J. Johnson
doaj   +1 more source

A reengineered common chain cytokine augments CD8+ T cell–dependent immunotherapy

JCI Insight, 2022
Cytokine therapy is limited by undesirable off-target side effects as well as terminal differentiation and exhaustion of chronically stimulated T cells.
Anirban Banerjee, Dongge Li, Yizhan Guo, Zhongcheng Mei, Christine Lau, Kelly Chen, John Westwick, Jeffery B. Klauda, Adam Schrum, Eric R. Lazear, Alexander S. Krupnick   +10 more
doaj   +1 more source

Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome‐enriched vesicles

Journal of Extracellular Vesicles, 2022
Tumour cells are characterized by having lost their differentiation state. They constitutively secrete small extracellular vesicles (sEV) called exosomes when they come from late endosomes.
Michel Record, Mehdi Attia, Kevin Carayon, Laly Pucheu, Julio Bunay, Régis Soulès, Silia Ayadi, Bruno Payré, Laure Perrin‐Cocon, Florence Bourgailh, Antonin Lamazière, Vincent Lotteau, Marc Poirot, Sandrine Silvente‐Poirot, Philippe de Medina   +14 more
doaj   +1 more source

Human lymphocyte differentiation antigens HB-10 and HB-11. II. Differential production of B cell growth and differentiation factors by distinct helper T cell subpopulations.

Journal of Immunology, 1985
Two monoclonal antibodies (HB-10 and HB-11), which react with human T, B, and NK cells, identify approximately 50% of the Leu-3+ T helper (TH) cells in adult blood.
T. Tedder, M. Cooper, L. Clement
semanticscholar   +1 more source

HLA Variation and SARS-CoV-2 Specific Antibody Response

Viruses, 2023
Differences in SARS-CoV-2-specific immune responses have been observed between individuals following natural infection or vaccination. In addition to already known factors, such as age, sex, COVID-19 severity, comorbidity, vaccination status, hybrid ...
Dawit Wolday, Chun Yiu Jordan Fung, Gregory Morgan, Selina Casalino, Erika Frangione, Jennifer Taher, Jordan P. Lerner-Ellis   +6 more
doaj   +1 more source