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Hypersensitivity pneumonitis of a bagpipe player: Fungal antigens as trigger?
Here we present a 79-year old man with chronic hypersensitivity pneumonitis probably caused by fungal contamination of a bagpipe. Several samples were taken from the patient's bagpipe.
Katharina Ziegler+5 more
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Radioimmunotherapy of fungal diseases: the therapeutic potential of cytocidal radiation delivered by antibody targeting fungal cell surface antigens [PDF]
Radioimmunotherapy is the targeted delivery of cytocidal radiation to cells via specific antibody. Although mature for the treatment of cancer, RIT of infectious diseases is in pre-clinical development. However, as there is an obvious and urgent need for
Joshua D Nosanchuk, Ekaterina eDadachova
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Will the Real Immunogens Please Stand Up: Exploiting the Immunogenic Potential of Cryptococcal Cell Antigens in Fungal Vaccine Development [PDF]
Cryptococcus neoformans is an opportunistic fungal pathogen that is a continuous global health concern, especially for immunocompromised populations. The World Health Organization recognized C.
Samantha L. Avina+3 more
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A fungal antigenic driver for Löfgren’s syndrome sarcoidosis [PDF]
Löfgren’s syndrome is an acute form of sarcoidosis that is characterized by the activation of CD4+ T helper cells. In this issue of JEM, Greaves et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20210785) identified a peptide derived from an airborne mold species that stimulates T cells of Löfgren’s syndrome patients in an HLA-DR3–restricted manner.
Clarice X. Lim, Thomas Weichhart
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Immunological assays based on the detection of circulating fungal biomarkers are helpful in clinical practice for diagnosing invasive fungal infections. Some of these targeting antigenic components are common to several different fungi. Histoplasmosis is
Juan David Puerta-Arias+2 more
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Novel Pneumocystis Antigens for Seroprevalence Studies
Pneumocystis jirovecii is the most common cause of fungal pneumonia in children under the age of 2 years. However, the inability to culture and propagate this organism has hampered the acquisition of a fungal genome as well as the development of ...
Dora Pungan+8 more
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Mannans are polysaccharide antigens expressed on the cell wall of different fungal species including Saccharomyces cerevisiae and Candida spp. These fungi are components of the normal intestinal microflora, and the presence of antibodies to fungal ...
Vadim B. Krylov+8 more
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Patients suffering from coronavirus disease-2019 (COVID-19) are susceptible to deadly secondary fungal infections such as COVID-19-associated pulmonary aspergillosis and COVID-19-associated mucormycosis.
Beeke Tappe+22 more
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Allergic Diseases Caused by Aspergillus Species in Patients with Cystic Fibrosis
Aspergillus spp. are spore forming molds; a subset of which are clinically relevant to humans and can cause significant morbidity and mortality. A.
Aidan K. Curran, David L. Hava
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Fungal Antigens Expressed during Invasive Aspergillosis [PDF]
ABSTRACTRabbits that had been infected intravenously with conidiospores ofAspergillus fumigatuswere used as sources of antibody for screening a λ phage cDNA expression library. The cDNA was derived fromA. fumigatusmRNA that had been extracted from newly formed, germling hyphae. Thirty-six antigens were identified using antisera from six rabbits. Though
Denikus, N.+5 more
openaire +4 more sources