Results 101 to 110 of about 135,006 (287)

Platelet compatibility and platelet antibodies detection: A step towards resolving dilemma in management of platelet refractoriness in oncology patients

Global Journal of Transfusion Medicine, 2019
Background: Platelet refractoriness complicates the provision of platelet transfusions- a critical and essential part in management of thrombocytopenia in Oncology patients. Platelet refractoriness poses challenge due to alloimmunization to HLA (Class I)
Sadhana Mangwana, Atin Kacker, Nikhil Simon   +2 more
doaj   +1 more source

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

Advanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidan Chen   +21 more
wiley   +1 more source

TGIF1 overexpression promotes glioma progression and worsens patient prognosis

Cancer Medicine, Volume 11, Issue 24, Page 5113-5128, December 2022., 2022
This study is the first to comprehensively analyze and reveal TGIF1, as a new oncogene, is closely related to the malignancy‐related phenotype of glioma, and that TGIF1 could be an independent risk factor for poor prognosis of glioma, which is expected to become a new target for individualized treatment of glioma patients.
Baoya Wang, Qiong Ma, Xuelin Wang, Kunshan Guo, Zhendong Liu, Gang Li   +5 more
wiley   +1 more source

Macrophage HM13/SPP Enhances Foamy Macrophage Formation and Atherogenesis

Advanced Science, EarlyView.
Previous research suggests that AIP may prevent atherogenic foamy macrophage formation. This study reveals that AIP, via its chaperone interaction with AHR, inhibits p38‐c‐JUN‐mediated transactivation of HM13, which encodes the ERAD protease HM13/SPP. HM13/SPP promotes foamy macrophage formation in addition to atherogenesis and plaque foamy macrophage ...
Yu Cao, Qirong Xie, Qiang Zheng, Jingping Zhang, Mengyu Yao, Zhongyong Du, Lujun Zhang, Tianyang Hu, Yunli Zhao, Jianlin Du, Yongyong Li, Yuxing Feng, ND Melgiri, Xiaodong Zhao, Rongzhong Huang, Yang Sun   +15 more
wiley   +1 more source

Molecular and cellular paradigms of multidrug resistance in cancer

Cancer Reports, Volume 5, Issue 12, December 2022., 2022
Abstract Background The acquisition of resistance to chemotherapy is a major hurdle in the successful application of cancer therapy. Several anticancer approaches, including chemotherapies, radiotherapy, surgery and targeted therapies are being employed for the treatment of cancer.
Foram U. Vaidya, Abu Sufiyan Chhipa, Vinita Mishra, Vishal Kumar Gupta, Shiv Govind Rawat, Ajay Kumar, Chandramani Pathak   +6 more
wiley   +1 more source

Genetic polymorphisms of human platelet antigens in Euro-African and Japanese descendants from Parana, Southern Brazil

Platelets, 2017
The frequency distributions of HPA-1 to HPA-6 and HPA-15 were evaluated in two Brazilian populations from Parana: a mixed population of predominantly Caucasians and a population of Japanese descendants.
Ana Paula Avenia Silvestre, Joana Maira Valentini Zacarias, Gláucia Andréia Soares Guelsin, Jeane Eliete Laguila Visentainer, Ana Maria Sell   +4 more
doaj   +1 more source

YC‐4‐3, a Novel Glycogen Synthase Kinase 3β Inhibitor, Alleviates the Endoplasmic Reticulum Stress of Macrophages in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
A patented GSK‐3β inhibitor (GSK‐3βi), new benzothiazepinone compounds (BTZs), YC‐4‐3, can modulate the inflammatory status of macrophages in primary immune thrombocytopenia (ITP), and improve the thrombocytopenia in murine ITP models by directly interacting with endoplasmic reticulum (ER) stress response.
Pengcheng Xu, Lili Ji, Yanxia Zhan, Yang Ou, Xia Shao, Xibing Zhuang, Fanli Hua, Feng Li, Hao Chen, Yong Chu, Yunfeng Cheng   +10 more
wiley   +1 more source

Automated fluorescence gating and size determination reduce variation in measured concentration of extracellular vesicles by flow cytometry

Cytometry Part A, Volume 101, Issue 12, Page 1049-1056, December 2022., 2022
Abstract Extracellular vesicles (EVs) are an upcoming biomarker for disease. However, the measured concentrations of EVs by flow cytometry are incomparable due to analytical variables. This study aimed to investigate how the choice of fluorophore, and thereby brightness, affects the measured concentration of EVs.
Angela Adriana Francisca Gankema, Bo Li, Rienk Nieuwland, Edwin van der Pol   +3 more
wiley   +1 more source

Frequency of anti-glycoprotein Ia/IIa (anti-HPA-5b,-5a) and anti-glycoprotein IIb/IIIa (anti-HPA-1a,-3a,-4a) alloantibodies in multiparous women of African descent

Pathology and Laboratory Medicine International, 2010
Zaccheaus A Jeremiah1, Justina E Oburu2, Osaro Erhabor1, Fiekumo I Buseri1, Teddy C Adias31Haematology and Blood Transfusion Science Unit, Department of Medical Laboratory Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island ...
Zaccheaus A Jeremiah, Justina E Oburu, Osaro Erhabor, et al   +3 more
doaj  

Recognition and management of antibodies to human platelet antigens in platelet transfusion–refractory patients [PDF]

Immunohematology, 2009
Abstract Platelet transfusion refractoriness is a problem for parous and multiply transfused patients, placing them at higher risk for morbidity and mortality when posttransfusion count increments are significantly lower than expected.
openaire   +3 more sources