Results 131 to 140 of about 99,037 (313)
Modulation of interferon-[alpha] secretion by activated platelets in systemic lupus erythematosus. [PDF]
, 2008 Type I interferons play a key role in systemic lupus erythematosus (SLE) pathogenesis as an "IFN signature" is found in the majority of patients with active SLE.
Bernard Weill +8 more
core +1 more source
Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity
Advanced Science, EarlyView.Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini +24 more
wiley +1 more source
Modern concepts of the platelet in health and disease [PDF]
, 1962 Thesis (M.D.)--Boston ...
Estes, J. Worth
core
An Engineered Solidified Peptide Hemocyte Sponge as Nanomotor Storage to Combat Bacterial Colitis
Advanced Science, EarlyView.Peptides immobilized via nickel coordination can stabilize the framework structure. Following coating with red blood cell membranes, these constructs are capable of continuously sequestering endotoxins and mitigating colonic pathogenic damage by alleviating bacterial‐induced ferroptosis.
Yuxin Fang +8 more
wiley +1 more source
Irradiation to Improve the Response to Immunotherapeutic Agents in Glioblastomas. [PDF]
, 2019 PurposeGlioblastoma (GBM) remains an incurable disease despite extensive treatment with surgical resection, irradiation, and temozolomide. In line with many other forms of aggressive cancers, GBM is currently under consideration as a target for ...
Kaprealian, Tania +6 more
core
Advanced Science, EarlyView.This study demonstrates that how hollow‐channel scaffolds promote vascularized bone regeneration via an immunomodulatory mechanism. The channel structures facilitate the formation of a neutrophil extracellular traps‐fibrin scaffold that recruits vascular endothelial growth factor A (VEGF‐A)‐secreting M2 macrophages to drive angiogenesis. Combining this
Guifang Wang +8 more
wiley +1 more source
Human platelet antigen Duv genotyping by PCR-SSP [PDF]
Journal of Thrombosis and Haemostasis, 2003 V, Jallu, C, Kaplan
openaire +2 more sources
Advanced Science, EarlyView.An intelligent early warning and treatment system for monkeypox, utilizing a sprayable AIEgen‐ liquid dressing (AIE@LD) that responds to lesion pH. Integrated with a smartphone app and cloud platform, it enables real‐time infection detection via fluorescence imaging and triggers on‐demand photodynamic therapy under white light, effectively eradicating ...
Wei Wang +14 more
wiley +1 more source
USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer
Advanced Science, EarlyView.USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen +9 more
wiley +1 more source
A machine-learning method for biobank-scale genetic prediction of blood group antigens.
PLoS Computational BiologyA key element for successful blood transfusion is compatibility of the patient and donor red blood cell (RBC) antigens. Precise antigen matching reduces the risk for immunization and other adverse transfusion outcomes.
Kati Hyvärinen +9 more
doaj +1 more source