Results 1 to 10 of about 12,887 (114)
Shared Mechanisms for Mutually Exclusive Expression and Antigenic Variation by Protozoan Parasites [PDF]
Frontiers in Cell and Developmental Biology, 2022 Cellular decision-making at the level of gene expression is a key process in the development and evolution of every organism. Variations in gene expression can lead to phenotypic diversity and the development of subpopulations with adaptive advantages.
Francesca Florini +2 more
openaire +3 more sources
Common strategies for antigenic variation by bacterial, fungal and protozoan pathogens [PDF]
Nature Reviews Microbiology, 2009 The complex relationships between infectious organisms and their hosts often reflect the continuing struggle of the pathogen to proliferate and spread to new hosts, and the need of the infected individual to control and potentially eradicate the infecting population.
Kirk W. Deitsch +2 more
openaire +3 more sources
Processing and presentation of antigens derived from intracellular protozoan parasites [PDF]
Current Opinion in Immunology, 2010 Control of parasitic protozoan infections requires the generation of efficient innate and adaptive immune responses, and in most cases both CD8 and CD4 T cells are necessary for host survival. Since intracellular protozoa remodel the vacuolar compartments in which they reside, it is not obvious how their antigens enter the MHC class I and class II ...
Romina S. Goldszmid, Alan Sher
openaire +3 more sources
Antigenic variation by protozoan parasites: insights from Babesia bovis [PDF]
Molecular Microbiology, 2005 SummaryAntigenic variation of surface membrane proteins by protozoan parasites enables these pathogenic organisms to avoid host immune responses and thus perpetuate long‐term infections. Babesia bovis, the causative agent of severe babesiosis in cattle, was previously shown to undergo antigenic variation through modifications to its primary surface ...
Ron Dzikowski, Kirk W. Deitsch
openaire +2 more sources
Protozoan predation, diversifying selection, and the evolution of antigenic diversity in Salmonella [PDF]
Proceedings of the National Academy of Sciences, 2004 Extensive population-level genetic variability at the Salmonella rfb locus, which encodes enzymes responsible for synthesis of the O-antigen polysaccharide, is thought to have arisen through frequency-dependent selection (FDS) by means of exposure of this pathogen to host immune systems.
Jeffrey G. Lawrence +3 more
openaire +3 more sources
Parasitologia, 2023 Sarcocystis aucheniae is a coccidian parasite that produces macroscopic sarcocysts in South American camelid (SAC) muscles and causes a disease known as SAC sarcocystosis. This parasitosis hampers the commercialization of llama and alpaca meat, a vital economic activity in the Andean regions.
Sarah Nathaly Wieser +6 more
openaire +4 more sources
Recombination-driven generation of the largest pathogen repository of antigen variants in the protozoan Trypanosoma cruzi [PDF]
BMC Genomics, 2016 The protozoan parasite Trypanosoma cruzi, causative agent of Chagas disease, depends upon a cell surface-expressed trans-sialidase (ts) to avoid activation of complement-mediated lysis and to enhance intracellular invasion. However these functions alone fail to account for the size of this gene family in T.
D. Brent Weatherly +2 more
openaire +3 more sources
Stress-Dependent Expression of a Polymorphic, Charged Antigen in the Protozoan Parasite Entamoeba histolytica [PDF]
Infection and Immunity, 2003 ABSTRACT We have identified a novel stress inducible gene, Ehssp1 in Entamoeba histolytica , the causative agent of amebiasis. Ehssp1 belongs to a polymorphic, multigene family and is present on multiple chromosomes. No homologue of this gene was found in the NCBI database.
S. Satish +3 more
openaire +3 more sources
Infection, Genetics and Evolution, 2004 A major impediment to vaccine development against infections caused by protozoan parasites such as Plasmodium falciparum and Trypanosoma is the extraordinary ability of these parasites to rapidly change their surface molecules, a phenomenon known as antigenic variation.
Douglas E. Norris +2 more
openaire +4 more sources
Surface antigenic change during differentiation of a parasitic protozoan, Leishmania mexicana: Identification by monoclonal antibodies. [PDF]
Proceedings of the National Academy of Sciences, 1982 The fusion of SP2/0 myeloma cells with spleen cells from mice immunized with Leishmania mexicana amazonensis promastigotes produced hybridoma clones. Indirect immunofluorescent antibody assay with live leishmanias showed that the monoclonal antibody 6H12 recognized only the antigens bound to the surface of L. mexicana amazonensis promastigotes. It also
Fong, D, Chang, K
openaire +3 more sources