Results 1 to 10 of about 1,219,115 (193)

Antibodies to variable surface antigens induce antigenic variation in the intestinal parasite Giardia lamblia

Nature Communications, 2023
The genomes of most protozoa encode families of variant surface antigens. In some parasitic microorganisms, it has been demonstrated that mutually exclusive changes in the expression of these antigens allow parasites to evade the host’s immune response ...
Albano H. Tenaglia, Lucas A. Luján, Diego N. Ríos, Cecilia R. Molina, Victor Midlej, Paula A. Iribarren, María A. Berazategui, Alessandro Torri, Alicia Saura, Damián O. Peralta, Macarena Rodríguez-Walker, Elmer A. Fernández, Juan P. Petiti, Marianela C. Serradell, Pablo R. Gargantini, Tim Sparwasser, Vanina E. Alvarez, Wanderley de Souza, Hugo D. Luján   +18 more
doaj   +2 more sources

Processing and presentation of antigens derived from intracellular protozoan parasites. [PDF]

Current Opinion in Immunology, 2010
Control of parasitic protozoan infections requires the generation of efficient innate and adaptive immune responses, and in most cases both CD8 and CD4 T cells are necessary for host survival. Since intracellular protozoa remodel the vacuolar compartments in which they reside, it is not obvious how their antigens enter the MHC class I and class II ...
R. Goldszmid, A. Sher
semanticscholar   +3 more sources

Antibodies to protozoan variable surface antigens induce antigenic variation

bioRxiv, 2022
AbstractThe genomes of most protozoa encode families of variant surface antigens, whose mutually exclusive changes in expression allow parasitic microorganisms to evade the host immune response1,2. It is widely assumed that antigenic variation in protozoan parasites is accomplished by the spontaneous appearance within the population of cells expressing
Albano H. Tenaglia, Lucas A. Luján, D. N. Ríos, V. Midlej, P. A. Iribarren, Cecilia R Molina, M. A. Berazategui, A. Torri, Alicia Saura, D. O. Peralta, Macarena Rodríguez-Walker, Elmer A Fernández, J. P. Petiti, M. C. Serradell, P. Gargantini, V. Alvarez, W. de Souza, H. Luján   +17 more
semanticscholar   +2 more sources

Fluorescence In Situ Hybridization (FISH) Tests for Identifying Protozoan and Bacterial Pathogens in Infectious Diseases

Diagnostics, 2022
Diagnosing and treating many infectious diseases depends on correctly identifying the causative pathogen. Characterization of pathogen-specific nucleic acid sequences by PCR is the most sensitive and specific method available for this purpose, although ...
Jyotsna S. Shah, Ranjan Ramasamy
doaj   +2 more sources

Discovery of Antigens and Cellular Mechanisms in the Protozoan Parasite Sarcocystis aucheniae Using Immunoproteomics

Parasitologia, 2023
Sarcocystis aucheniae is a coccidian parasite that produces macroscopic sarcocysts in South American camelid (SAC) muscles and causes a disease known as SAC sarcocystosis.
Sarah Nathaly Wieser, Cecilia Decker-Franco, Paloma de Alba, Sandra Romero, Alejandro Ferrari, Leonhard Schnittger, Mónica Florin-Christensen   +6 more
doaj   +4 more sources

Computational vaccine development against protozoa [PDF]

Computational and Structural Biotechnology Journal
Protozoan parasites remain a major global health and economic burden, particularly in low- and middle-income countries. Conventional strategies such as chemotherapy and vector control face growing limitations due to resistance, toxicity, and ...
Omar Hashim, Isabelle Dimier-Poisson
doaj   +2 more sources

Characterization of the Fine Specificity of Bovine CD8 T-Cell Responses to Defined Antigens from the Protozoan Parasite Theileria parva [PDF]

Infection and Immunity, 2007
ABSTRACTImmunity against the bovine intracellular protozoan parasiteTheileria parvahas been shown to be mediated by CD8 T cells. Six antigens targeted by CD8 T cells fromT. parva-immune cattle of different major histocompatibility complex (MHC) genotypes have been identified, raising the prospect of developing a subunit vaccine.
Simon P. Graham, R. Pelle, M. Yamage, D. Mwangi, Y. Honda, R. Mwakubambanya, E. D. de Villiers, E. Abuya, E. Awino, J. Gachanja, Ferdinand Mbwika, A. Muthiani, C. Muriuki, J. Nyanjui, Fredrick O Onono, J. Osaso, Victor Riitho, R. Saya, S. Ellis, D. McKeever, N. Machugh, S. Gilbert, J. Audonnet, W. Morrison, P. van der Bruggen, E. Taracha   +25 more
semanticscholar   +6 more sources

Inhibitory effects on protein kinase C activity by lipophosphoglycan fragments and glycosylphosphatidylinositol antigens of the protozoan parasite Leishmania. [PDF]

Biochemical Journal, 1989
Fragments of the lipophosphoglycan of Leishmania donovani were generated by phospholipase C digestion and mild acid hydrolysis. The fragments were purified and examined for inhibitory activity on protein kinase C isolated from rat brains. On a molar basis, the 1-O-alkylglycerol portion of LPG exhibited the most inhibitory activity, whereas the ...
T. Mcneely, G. Rosen, M. Londner, S. Turco   +3 more
semanticscholar   +3 more sources

Far beyond Phagocytosis: Phagocyte-Derived Extracellular Traps Act Efficiently against Protozoan Parasites In Vitro and In Vivo

Mediators of Inflammation, 2016
Professional mononuclear phagocytes such as polymorphonuclear neutrophils (PMN), monocytes, and macrophages are considered as the first line of defence against invasive pathogens.
Liliana M. R. Silva, Tamara Muñoz-Caro, Rafael A. Burgos, Maria A. Hidalgo, Anja Taubert, Carlos Hermosilla   +5 more
doaj   +2 more sources

T-cell responses to viral, bacterial and protozoan antigens in rheumatoid inflammation. Selective migration of T cells to synovial tissue. [PDF]

Rheumatology, 2001
To identify any preferential or selective migration of T-cell specificities to inflamed tissues of rheumatoid arthritis (RA) patients.Lymphocytes from peripheral blood (PB) and synovial tissue (ST) were isolated from RA patients and stimulated with a panel of crude antigen preparations from 18 bacterial, protozoan and viral sources.
K. R. Shadidi, T. Aarvak, S. Jeansson, J. Henriksen, J. Natvig, K. Thompson   +5 more
semanticscholar   +3 more sources