Results 11 to 20 of about 18,221 (161)
Journal of NanobiotechnologyBackground Lipid nanoparticles (LNP) are a safe and effective messenger RNA (mRNA) delivery system for vaccine applications, as shown by the COVID-19 mRNA vaccines.
Renata S. Fernandes +13 more
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Shared Mechanisms for Mutually Exclusive Expression and Antigenic Variation by Protozoan Parasites [PDF]
Frontiers in Cell and Developmental Biology, 2022 Cellular decision-making at the level of gene expression is a key process in the development and evolution of every organism. Variations in gene expression can lead to phenotypic diversity and the development of subpopulations with adaptive advantages.
Francesca Florini +2 more
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Antigenic variation by protozoan parasites: insights from Babesia bovis [PDF]
Molecular Microbiology, 2005 SummaryAntigenic variation of surface membrane proteins by protozoan parasites enables these pathogenic organisms to avoid host immune responses and thus perpetuate long‐term infections. Babesia bovis, the causative agent of severe babesiosis in cattle, was previously shown to undergo antigenic variation through modifications to its primary surface ...
Ron, Dzikowski, Kirk, Deitsch
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Processing and presentation of antigens derived from intracellular protozoan parasites [PDF]
Current Opinion in Immunology, 2010 Control of parasitic protozoan infections requires the generation of efficient innate and adaptive immune responses, and in most cases both CD8 and CD4 T cells are necessary for host survival. Since intracellular protozoa remodel the vacuolar compartments in which they reside, it is not obvious how their antigens enter the MHC class I and class II ...
Romina S, Goldszmid, Alan, Sher
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Common strategies for antigenic variation by bacterial, fungal and protozoan pathogens [PDF]
Nature Reviews Microbiology, 2009 The complex relationships between infectious organisms and their hosts often reflect the continuing struggle of the pathogen to proliferate and spread to new hosts, and the need of the infected individual to control and potentially eradicate the infecting population.
Kirk W, Deitsch +2 more
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Protozoan predation, diversifying selection, and the evolution of antigenic diversity in Salmonella [PDF]
Proceedings of the National Academy of Sciences, 2004 Extensive population-level genetic variability at the Salmonella rfb locus, which encodes enzymes responsible for synthesis of the O-antigen polysaccharide, is thought to have arisen through frequency-dependent selection (FDS) by means of exposure of this pathogen to host immune systems.
Hans, Wildschutte +3 more
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Insight into the current Toxoplasma gondii DNA vaccine: a review article
Expert Review of Vaccines, 2023 Introduction Toxoplasma gondii (T.gondii) is a widespread protozoan with significant economic losses and public health importance. But so far, the protective effect of reported DNA-based vaccines fluctuates widely, and no study has demonstrated complete ...
Xirui Zhang +8 more
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Duffy blood group system and the malaria adaptation process in humans
Revista Brasileira de Hematologia e Hemoterapia, 2011 Malaria is an acute infectious disease caused by the protozoa of the genus Plasmodium. The antigens of the Duffy Blood Group System, in addition to incompatibilities in transfusions and hemolytic disease of the newborn, are of great interest in medicine ...
Gledson Barbosa de Carvalho +1 more
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Improved canine and human visceral leishmaniasis immunodiagnosis using combinations of synthetic peptides in enzyme-linked immunosorbent assay. [PDF]
PLoS Neglected Tropical Diseases, 2012 BACKGROUND: Zoonotic visceral leishmaniasis (VL) is a severe infectious disease caused by protozoan parasites of the genus Leishmania and the domestic dogs are the main urban parasite reservoir hosts. In Brazil, indirect fluorescence antibody tests (IFAT)
Míriam Maria Costa +8 more
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Animals, 2020 Toxoplasmosis is caused by an intracellular protozoan, Toxoplasma gondii, and is a parasitic disease that occurs in all warm-blooded animals, including humans.
Bartłomiej Ferra +2 more
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