Results 241 to 250 of about 45,582 (279)

T Cell Glycoengineering to Modulate Immune‐Tumor Crosstalk: A Universal Non‐Genetic Strategy for Enhanced Tumor Immunotherapy

open access: yesAdvanced Science, Volume 13, Issue 8, 9 February 2026.
This study describes a T cell surface engineering strategy that integrates polymer materials with tumor immunology, aiming to achieve broad‐spectrum anti‐tumor applications of glycopolymer‐engineered T (G‐T) cells via non‐genetic modification. Glycopolymer engineering generally modulates immune‐tumor crosstalk through specific cell‐cell interactions ...
Lihua Yao   +8 more
wiley   +1 more source

A Glycopeptide Mosaic Vaccine Elicits Robust Antitumor Immunity by Targeting Glycan Heterogeneity. [PDF]

open access: yesJACS Au
Wu Y   +14 more
europepmc   +1 more source

Enzymatic Synthesis of Tumor-Associated Carbohydrate Antigen Globo-H Hexasaccharide

Organic Letters, 2008
We report the enzymatic synthesis of an important tumor-associated carbohydrate antigen, Globo-H hexasaccharide. Starting with Lac-OBn as the initial acceptor, this approach employs three glycosyltransferases: LgtC, an alpha1,4-galactosyltransferase; LgtD, a bifunctional beta1,3-galactosyl/beta1,3-N-acetylgalactosaminyltransferase; and WbsJ, an alpha1 ...
Doris M, Su   +5 more
openaire   +3 more sources

Biosignals Modulated by Tumor‐Associated Carbohydrate Antigens

Annals of the New York Academy of Sciences, 2006
Abstract:  Based on the remodeling of glycosphingolipids on the human tumor cell lines with manipulation of glycosyltransferase genes, roles of sugar moieties in tumor‐associated carbohydrate antigens have been analyzed. Two main topics, that is, the roles of ganglioside GD3 in human malignant melanomas and those of GD2 in small cell lung cancer (SCLC)
Koichi, Furukawa   +3 more
openaire   +2 more sources

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