Mathematical Modeling Insights into Improving CAR T cell Therapy for Solid Tumors: Antigen Heterogeneity and Bystander Effects [PDF]
npj Systems Biology and Applications, 10(1), 105 (2024), 2023 As an adoptive cellular therapy, Chimeric Antigen Receptor T-cell (CAR T-cell) therapy has shown remarkable success in hematological malignancies, but only limited efficacy against solid tumors. Compared with blood cancers, solid tumors present a unique set of challenges that ultimately neutralize the function of CAR T-cells.
arxiv +1 more source
Checkpoint Blockade Cancer Immunotherapy Targets Tumour-Specific Mutant Antigens
Nature, 2014 The immune system influences the fate of developing cancers by not only functioning as a tumour promoter that facilitates cellular transformation, promotes tumour growth and sculpts tumour cell immunogenicity, but also as an extrinsic tumour suppressor ...
M. Gubin +26 more
semanticscholar +1 more source
Challenges to the development of antigen-specific breast cancer vaccines [PDF]
, 2001 Continued progress in the development of antigen-specific breast cancer vaccines depends on the identification of appropriate target antigens, the establishment of effective immunization strategies, and the ability to circumvent immune escape mechanisms.
B Thurner +32 more
core +2 more sources
The role of antigen-competitive dynamics in regulating the immune response [PDF]
Bulletin of Mathematical Biology, 83(5): 40 (2021), 2021 The clonal expansion of T cells during an infection is tightly regulated to ensure an appropriate immune response against invading pathogens. Although experiments have mapped the trajectory from expansion to contraction, the interplay between mechanisms that control this response are not fully understood.
arxiv +1 more source
Definition of Drosophila hemocyte subsets by cell-type specific antigens. [PDF]
, 2007 We analyzed the heterogeneity of Drosophila hemocytes on the basis of the expression of cell-type specific antigens. The antigens characterize distinct subsets which partially overlap with those defined by morphological criteria.
Andó, István +9 more
core +1 more source
Noncoding regions are the main source of targetable tumor-specific antigens
Science Translational Medicine, 2018 A proteogenomic method identifies potentially actionable tumor-specific antigens and shows that most of them are not coded by classic exons. Expanding the landscape of immunotherapy targets Most searches for druggable tumor-specific antigens (TSAs) start
Céline M. Laumont +18 more
semanticscholar +1 more source
Recombinant anticoccidial vaccines - a cup half full? [PDF]
, 2017 Eimeria species parasites can cause the disease coccidiosis, most notably in chickens. The occurrence of coccidiosis is currently controlled through a combination of good husbandry, chemoprophylaxis and/or live parasite vaccination; however, scalable ...
Ahmad +119 more
core +1 more source
Immunophenotypic Aberrancies in Acute Leukemia: A Tertiary Care Centre Experience
Oman Medical Journal, 2021 Objectives: Acute leukemias (AL) are a heterogeneous group of hematological malignancies with the presence of 20% or more blasts in the peripheral blood or bone marrow.
Monika Gupta +5 more
doaj +1 more source
The onset of occupational diseases in mushroom cultivation and handling operators: a review
Italian Journal of Mycology, 2019 The paper presents a review on health hazards involving operators that cultivate and handle mushrooms. Intensive production of edible and medicinal fungi is a common agricultural management all over the world and involves a number of operators whose ...
Barbara Ficociello +4 more
doaj +1 more source
Involvement of Mhc Loci in immune responses that are not Ir-gene-controlled [PDF]
, 1982 Twenty-nine randomly chosen, soluble antigens, many of them highly complex, were used to immunize mice of two strains, C3H and B10.RIII. Lymphnode cells from the immunized mice were restimulated in vitro with the priming antigens and the proliferative ...
C. J. Kreo +28 more
core +1 more source