Analysis of host responses to Mycobacterium tuberculosis antigens in a multi-site study of subjects with different TB and HIV infection states in sub-Saharan Africa. [PDF]
, 2013 BACKGROUND: Tuberculosis (TB) remains a global health threat with 9 million new cases and 1.4 million deaths per year. In order to develop a protective vaccine, we need to define the antigens expressed by Mycobacterium tuberculosis (Mtb), which are ...
AA Odutola +46 more
core +24 more sources
New 'Antigens' in Membranous Nephropathy.
Journal of the American Society of Nephrology, 2020 Membranous nephropathy (MN) occurs due to deposition of immune complexes along the subepithelial region of glomerular basement membrane. Two previously identified target antigens for the immune complexes, PLA2R (identified in 2009) and THSD7A (in 2014 ...
S. Sethi
semanticscholar +1 more source
Journal of Experimental Medicine, 2001 Toll-like receptors (TLRs) are ancient microbial pattern recognition receptors highly conserved from Drosophila to humans. To investigate if subsets of human dendritic cell precursors (pre-DC), including monocytes (pre-DC1), plasmacytoid DC precursors ...
N. Kadowaki +6 more
semanticscholar +1 more source
Serotyping for homotransplantation V. Evaluation of a matching scheme [PDF]
, 1966 An attempt was made to determine whether 36 long-term kidney homograft recipients and their donors were compatible for 7 major leukocyte groups. It was found that 21 of these recipients were surviving 2 to 3 years in spite of incompatibility for 1 or 2 ...
Faris, TD +7 more
core +1 more source
Noncoding regions are the main source of targetable tumor-specific antigens
Science Translational Medicine, 2018 A proteogenomic method identifies potentially actionable tumor-specific antigens and shows that most of them are not coded by classic exons. Expanding the landscape of immunotherapy targets Most searches for druggable tumor-specific antigens (TSAs) start
Céline M. Laumont +18 more
semanticscholar +1 more source
Challenges to the development of antigen-specific breast cancer vaccines [PDF]
, 2001 Continued progress in the development of antigen-specific breast cancer vaccines depends on the identification of appropriate target antigens, the establishment of effective immunization strategies, and the ability to circumvent immune escape mechanisms.
B Thurner +32 more
core +2 more sources
CD4+ Th immunogenicity of the Ascaris spp. secreted products [PDF]
, 2020 Ascaris spp. is a major health problem of humans and animals alike, and understanding the immunogenicity of its antigens is required for developing urgently needed vaccines.
Bertazzon, Miriam +6 more
core +1 more source
Checkpoint Blockade Cancer Immunotherapy Targets Tumour-Specific Mutant Antigens
Nature, 2014 The immune system influences the fate of developing cancers by not only functioning as a tumour promoter that facilitates cellular transformation, promotes tumour growth and sculpts tumour cell immunogenicity, but also as an extrinsic tumour suppressor ...
M. Gubin +26 more
semanticscholar +1 more source
Definition of Drosophila hemocyte subsets by cell-type specific antigens. [PDF]
, 2007 We analyzed the heterogeneity of Drosophila hemocytes on the basis of the expression of cell-type specific antigens. The antigens characterize distinct subsets which partially overlap with those defined by morphological criteria.
Andó, István +9 more
core +1 more source
Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteins [PDF]
, 2010 Introduction: Rheumatoid arthritis (RA) is an inflammatory disease, which results in destruction of the joint. The presence of immune complexes (IC) in serum and synovial fluid of RA patients might contribute to this articular damage through different ...
De Ceuleneer, Marlies +5 more
core +3 more sources