Results 11 to 20 of about 884,279 (321)
Frontiers in Immunology, 2020 Protective vaccines for hypervariable pathogens are urgently needed. It has been proposed that amputating highly variable epitopes from vaccine antigens would induce the production of broadly protective antibodies targeting conserved epitopes. However, so far, these approaches have failed, partially because conserved epitopes are occluded in vivo and ...
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Discriminating antigen and non-antigen using proteome dissimilarity: bacterial antigens [PDF]
Bioinformation, 2010 It has been postulated that immunogenicity results from the overall dissimilarity of pathogenic proteins versus the host proteome. We have sought to use this concept to discriminate between antigens and non-antigens of bacterial origin. Sets of 100 known antigenic and nonantigenic peptide sequences from bacteria were compared to human and mouse ...
Kamna Ramakrishnan, Darren R. Flower
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Antigen Stability Controls Antigen Presentation [PDF]
Journal of Biological Chemistry, 2004 We investigated whether protein stability controls antigen presentation using a four disulfide-containing snake toxin and three derivatives carrying one or two mutations (L1A, L1A/H4Y, and H4Y). These mutations were anticipated to increase (H4Y) or decrease (L1A) the antigen non-covalent stabilizing interactions, H4Y being naturally and frequently ...
Jean-Luc Tarride +6 more
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Main features of DNA-based immunization vectors
Brazilian Journal of Medical and Biological Research, 1999 DNA-based immunization has initiated a new era of vaccine research. One of the main goals of gene vaccine development is the control of the levels of expression in vivo for efficient immunization.
V. Azevedo +5 more
doaj +1 more source
Regulation of T cell expansion by antigen presentation dynamics [PDF]
PNAS 2019, 116 (13) 5914-5919, 2018 An essential feature of the adaptive immune system is the proliferation of antigen-specific lymphocytes during an immune reaction to form a large pool of effector cells. This proliferation must be regulated to ensure an effective response to infection while avoiding immunopathology.
arxiv +1 more source
CD22: A Regulator of Innate and Adaptive B Cell Responses and Autoimmunity
Frontiers in Immunology, 2018 CD22 (Siglec 2) is a receptor predominantly restricted to B cells. It was initially characterized over 30 years ago and named “CD22” in 1984 at the 2nd International workshop in Boston (1).
Edward A. Clark +2 more
doaj +1 more source
Molecular typing of RhD-negative blood donors with C and/or E antigen [PDF]
Scripta Medica, 2019 Background: Most people are either RhD positive or RhD negative, but there is also a number of persons with D antigen variants. The aim of this study was to prove, by using molecular diagnostic tests, whether the RHD gene and D antigen on the red cell ...
Guzijan Gordana +4 more
doaj
OncoImmunology, 2018 The profound but frequently transient clinical responses to BRAFV600 inhibitor (BRAFi) treatment in melanoma emphasize the need for combinatorial therapies.
Natalia Pieper +17 more
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Molecular tug of war reveals adaptive potential of an immune cell repertoire [PDF]
arXiv, 2022 The adaptive immune system constantly remodels its lymphocyte repertoire for better protection against future pathogens. Its ability to improve antigen recognition on the fly relies on somatic mutation and selective expansion of B lymphocytes expressing high-affinity antigen receptors.
arxiv