Results 51 to 60 of about 2,037,182 (315)

Exploring the immunology of parasitism--from surface antigens to the hygiene hypothesis [PDF]

, 2009
Helminth immunology is a field which has changed beyond recognition in the past 30 years, transformed not only by new technologies from cDNA cloning to flow cytometry, but also conceptually as our definition of host immune pathways has matured.
R. M. MAIZELS, Maizels, R M
core   +1 more source

Update on New Antigens in the Pathogenesis of Membranous Nephropathy [PDF]

, 2022
Previously, membranous nephropathies were divided into primary and secondary categories when the exact mechanism or pathogenetic factor were unknown. Approximately 70% accounted for primary membranous nephropathies.
Aris Tsalouchos, Maurizio Salvadori
core   +1 more source

ICAMs Are Not Obligatory for Functional Immune Synapses between Naive CD4 T Cells and Lymph Node DCs

Cell Reports, 2018
Protective immune responses depend on the formation of immune synapses between T cells and antigen-presenting cells (APCs). The two main LFA-1 ligands, ICAM-1 and ICAM-2, are co-expressed on many cell types, including APCs and blood vessels.
Sara W. Feigelson, Adam Solomon, Adi Biram, Miki Hatzav, Moria Lichtenstein, Ofer Regev, Stav Kozlovski, Diana Varol, Caterina Curato, Dena Leshkowitz, Steffen Jung, Ziv Shulman, Ronen Alon   +12 more
doaj   +1 more source

CcpA- and Shm2-Pulsed Myeloid Dendritic Cells Induce T-Cell Activation and Enhance the Neutrophilic Oxidative Burst Response to Aspergillus fumigatus

Frontiers in Immunology, 2021
Aspergillus fumigatus causes life-threatening opportunistic infections in immunocompromised patients. As therapeutic outcomes of invasive aspergillosis (IA) are often unsatisfactory, the development of targeted immunotherapy remains an important goal ...
Lukas Page, Julia Wallstabe, Julia Wallstabe, Jasmin Lother, Jasmin Lother, Maximilian Bauser, Olaf Kniemeyer, Olaf Kniemeyer, Lea Strobel, Vera Voltersen, Vera Voltersen, Janka Teutschbein, Janka Teutschbein, Peter Hortschansky, Peter Hortschansky, Charles Oliver Morton, Axel A. Brakhage, Axel A. Brakhage, Max Topp, Hermann Einsele, Sebastian Wurster, Juergen Loeffler   +21 more
doaj   +1 more source

Farmer’s Lung Disease: the Development of Antigens in Moulding Hay [PDF]

, 1964
Antigens important in farmer’s lung disease (FLH antigen complex) developed in wet hay ( 2 30 yo water content) 4-6 days after baling; their development was associated with increases in pH value of the hay, in content of soluble and volatile nitrogen ...
P. H. Gregory, Maureen E. Lacey, Rothamsted Experimental Station, F. A. Skinner, G. N. Festenstein, Festenstein, G. N., Lacey, M. E., Skinner, F. A., Gregory, P. H., Jenkins, P. A., P. A. Jenkins, Pepys, J., J. Pepys   +12 more
core   +1 more source

Increased levels of invariant natural killer T lymphocytes worsen metabolic abnormalities and atherosclerosis in obese mice

Journal of Lipid Research, 2013
Obesity is a chronic inflammatory state characterized by infiltration of adipose tissue by immune cell populations, including T lymphocytes. Natural killer T (NKT) cells, a specialized lymphocyte subset recognizing lipid antigens, can be pro- or anti ...
Savitha Subramanian, Michael S. Turner, Yilei Ding, Leela Goodspeed, Shari Wang, Jane H. Buckner, Kevin O'Brien, Godfrey S. Getz, Catherine A. Reardon, Alan Chait   +9 more
doaj   +1 more source

The Prioritization of Cancer Antigens: A National Cancer Institute Pilot Project for the Acceleration of Translational Research

Clinical Cancer Research, 2009
The purpose of the National Cancer Institute pilot project to prioritize cancer antigens was to develop a well-vetted, priority-ranked list of cancer vaccine target antigens based on predefined and preweighted objective criteria.
M. Cheever, J. Allison, A. Ferris, O. Finn, Ben Hastings, T. Hecht, I. Mellman, S. Prindiville, R. Steinman, J. Viner, L. Weiner, L. Matrisian   +11 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination. [PDF]

, 2007
Mycobacterium bovis BCG is widely used as a vaccine against tuberculosis (TB), despite its variable protective efficacy. Relatively little is known about the immune response profiles following BCG vaccination in relation to protection against TB. Here we
Klein, Michèl R, Friggen, Annemieke H, Geluk, Annemieke, Lin, May Young, Verduyn, Marleen JC, Voskuil, Martin I, Huygen, Kris, Franken, Kees LMC, Smith, Steven G, van Meijgaarden, Krista E, Dockrell, Hazel M, Stewart, Amanda L, Ottenhoff, Tom HM   +12 more
core   +1 more source

Trypanosoma cruzi Antigenic Proteins Shared with Acute Lymphoblastic Leukemia and Neuroblastoma

Pharmaceuticals, 2022
Background. Research studies indicate that immunization with protein extracts of Trypanosoma cruzi, the protozoan parasite that causes Chagas disease, prevents the appearance of tumors in 60% of mice injected with the murine lung carcinoma tumor line ...
Leticia Eligio García, María del Pilar Crisóstomo Vázquez, Víctor Alberto Maravelez Acosta, Mariana Soria Guerrero, Adrián Cortés Campos, Enedina Jiménez Cardoso   +5 more
doaj   +1 more source