Results 71 to 80 of about 1,337,759 (297)

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Recent Advances in Nanovaccines Using Biomimetic Immunomodulatory Materials

Pharmaceutics, 2019
The development of vaccines plays a vital role in the effective control of several fatal diseases. However, effective prophylactic and therapeutic vaccines have yet to be developed for completely curing deadly diseases, such as cancer, malaria, HIV, and ...
Veena Vijayan, Adityanarayan Mohapatra, Saji Uthaman, In-Kyu Park   +3 more
doaj   +1 more source

Fundamental differences between natural antibodies and polyreactive immunoglobulins [PDF]

The Ukrainian Biochemical Journal, 2015
A problem of similarity and differences between so-called polyreactive immunoglobulins (PRIGs) and natural antibodies (NAbs), capable of cross-reacting with some structurally dissimilar antigens, has been considered.
S. A. Bobrovnik, M. A. Demchenko, S. V. Komisarenko   +2 more
doaj   +1 more source

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

Journal of Experimental Medicine, 1998
Dendritic cells, but not macrophages, efficiently phagocytose apoptotic cells and cross-present viral, tumor, and self-antigens to CD8+ T cells. This in vitro pathway corresponds to the in vivo phenomena of cross-priming and cross-tolerance.
M. Albert, S. Pearce, Loise M. Francisco, B. Sauter, P. Roy, R. Silverstein, N. Bhardwaj   +6 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Main features of DNA-based immunization vectors

Brazilian Journal of Medical and Biological Research, 1999
DNA-based immunization has initiated a new era of vaccine research. One of the main goals of gene vaccine development is the control of the levels of expression in vivo for efficient immunization.
V. Azevedo, G. Levitus, A. Miyoshi, A.L. Cândido, A.M. Goes, S.C. Oliveira   +5 more
doaj   +1 more source

SPECIFIC CARCINOEMBRYONIC ANTIGENS OF THE HUMAN DIGESTIVE SYSTEM

Journal of Experimental Medicine, 1965
A wide variety of human adult and fetal tissues were studied by immune-diffusion techniques in agar gel to determine whether they contained the tumor-specific antigen(s) previously found in coionic cancers.
P. Gold, S. Freedman
semanticscholar   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

The onset of occupational diseases in mushroom cultivation and handling operators: a review

Italian Journal of Mycology, 2019
The paper presents a review on health hazards involving operators that cultivate and handle mushrooms. Intensive production of edible and medicinal fungi is a common agricultural management all over the world and involves a number of operators whose ...
Barbara Ficociello, Eva Masciarelli, Laura Casorri, Angelo Cichelli, Giovanni Pacioni   +4 more
doaj   +1 more source

Focused Specificity of Intestinal Th17 Cells towards Commensal Bacterial Antigens

Nature, 2014
T-helper-17 (TH17) cells have critical roles in mucosal defence and in autoimmune disease pathogenesis. They are most abundant in the small intestine lamina propria, where their presence requires colonization of mice with microbiota.
Yi Yang, M. B. Torchinsky, M. Gobert, Huizhong Xiong, Mo Xu, Jonathan L. Linehan, Francis Alonzo, Charles P. Ng, A. Chen, X. W. Lin, A. Sczesnak, J. Liao, V. Torres, M. Jenkins, J. Lafaille, D. Littman   +15 more
semanticscholar   +1 more source